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pro vyhledávání: '"Michel LeHir"'
Autor:
Franziska Theilig, Wilhelm Kriz, Robert Koesters, Michel LeHir, Hiltraud Hosser, Nicolas Picard, Rolf Gebhardt, Brigitte Kaissling, Adam B. Glick, Brunhilde Hähnel, Hermann Josef Gröne
Publikováno v:
The American Journal of Pathology. 177:632-643
We recently showed in a tetracycline-controlled transgenic mouse model that overexpression of transforming growth factor (TGF)-beta1 in renal tubules induces widespread peritubular fibrosis and focal degeneration of nephrons. In the present study we
Autor:
Wilhelm Kriz, Michel LeHir
Publikováno v:
Current Opinion in Nephrology and Hypertension. 16:184-191
The term 'focal segmental glomerulosclerosis' covers a variety of diseases with different histopathological patterns. There is a need for clues to interpret histological findings in terms of etiology. Studies in transgenic animal models published in
Publikováno v:
American journal of physiology. Renal physiology. 304(4)
Progressive loss of podocytes is the most frequent cause accounting for end-stage renal failure. Podocytes are complex, terminally differentiated cells incapable of replicating. Thus lost podocytes cannot be replaced by proliferation of neighboring u
Publikováno v:
Biochimica et biophysica acta. 1832(7)
Chronic kidney disease at a certain advanced stage inevitably progresses to end stage renal failure characterized by the progressing loss of nephrons accompanied by the increasing appearance of fibrotic tissue, called renal fibrosis. The urgent quest
Autor:
Michel Lehir, Wilhelm Kriz
Publikováno v:
Kidney international. 67(2)
Pathways to nephron loss starting from glomerular diseases—Insights from animal models.Studies of glomerular diseases in animal models show that progression toward nephron loss starts with extracapillary lesions, whereby podocytes play the central