Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Michel L. Ntemgwa"'
Autor:
Thomas d'Aquin Toni, Ricardo Jorge Camacho, Michel L. Ntemgwa, Bluma G. Brenner, Mark A. Wainberg
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:3611-3619
Scientists established long ago that human immunodeficiency virus type 1 (HIV-1) is the causative agent of AIDS ([4][1], [30][2], [48][3]). HIV is known to severely damage the immune system by selectively infecting T-helper (CD4+) lymphocytes. This c
Autor:
Richard G. Lalonde, Daniela Moisi, Bluma G. Brenner, Mark A. Wainberg, Michel L. Ntemgwa, Valeria Micheli, Maureen Oliveira
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:3861-3869
Mutations in the RNase H domain of human immunodeficiency virus type 1 RT have been reported to cause resistance to zidovudine (ZDV) in vitro. However, very limited data on the in vivo relevance of these mutations in patients exist to date. This stud
Autor:
Mark A. Wainberg, Dimitrios Coutsinos, Jorge L. Martinez-Cajas, Fernando A. Frankel, Hongtao Xu, Michel L. Ntemgwa, Bluma G. Brenner
Publikováno v:
Retrovirology, Vol 6, Iss 1, p 14 (2009)
Retrovirology
Retrovirology
Background We investigated the effects of mutations K65R and K65R plus M184V on enzymatic function and mechanisms of drug resistance in subtype C reverse transcriptase (RT). Methods Recombinant subtype C HIV-1 RTs containing K65R or K65R+M184V were p