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pro vyhledávání: '"Michel Jordi"'
Autor:
Michel Jordi, John H. Miller, J. Fernando Díaz, Benet Pera, Grégory Menchon, Juan Estévez Gallego, José Manuel Andreu, Javier Rodríguez-Salarichs, Didier Zuwerra, Andrea E. Prota, Enrique Calvo, Gonzalo Sáez-Calvo, Jessica J. Field, Karl-Heinz Altmann
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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41 p.-8 fig.-2 tab. Field, Jessica J. et al.
The marine natural product zampanolide and analogues thereof constitute a new chemotype of taxoid site microtubule-stabilizing agents with a covalent mechanism of action. Zampanolide-ligated tubulin h
The marine natural product zampanolide and analogues thereof constitute a new chemotype of taxoid site microtubule-stabilizing agents with a covalent mechanism of action. Zampanolide-ligated tubulin h
Autor:
Doriano Fabbro, Karl-Heinz Altmann, Joerg Trappe, Peter Drueckes, Luca Fransioli-Ignazio, Michel Jordi, Tatjana Hofmann, Marc Liniger, Christian Neuhaus
Publikováno v:
ACS Medicinal Chemistry Letters. 2:22-27
The natural product L-783277 is a resorcylic lactone type covalent kinase inhibitor. We have prepared the 5'-deoxy analogue of L-783277 (1) in a stereoselective fashion. Remarkably, this analogue retains almost the full kinase inhibitory potential of
Autor:
Benet Pera, Malcolm A.S. Moore, Ruben Hoya-Arias, Karl-Heinz Altmann, José Fernando Díaz, Michel Jordi, Wei-Shuo Fang
Publikováno v:
Blood. 122:4225-4225
Poor outcomes in patients with acute myeloid leukemia (AML) are related to the high proportion of patients with chemorefractory disease or relapse after an initial response due to the development of resistance. This treatment failure is frequently du