Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michel J. Hamelin"'
Autor:
Michael Cuddy, John G. Ondeyka, Keith Korsun, Peter B. Simpson, Xin Meng, Doris F. Cully, Birgit T. Priest, Michel J. Hamelin
Publikováno v:
ASSAY and Drug Development Technologies. 3:59-64
Invertebrate glutamate-gated chloride channels (GluCls) are important targets for anthelmintics and insecticides such as ivermectin. To facilitate screening for novel GluCl modulators, the Caenorhabditis elegans GluCl alpha2beta channel was chosen as
Publikováno v:
Journal of the Association for Laboratory Automation. 5:79-84
here has been relatively little progress in the area of highthroughput screening for antiparasitic animal health tar-gets, which involve whole organisms such as Haemonchus contortus and Caenorhabditis elegans. Mostassays involve identifying compounds
Autor:
Philip S. Paress, Sheng-Shung Pong, Donna L. Hreniuk, Paul A. Liberator, Michael Rigby, Roy G. Smith, Oksana C. Palyha, Arthur A. Patchett, Michel J. Hamelin, Robert P. Heavens, Andrew D. Howard, Patrick R. Griffin, David G. Melillo, Charles Rosenblum, Lee-Yuh Chaung, Ravi P. Nargund, Michael Chou, Jennifer W. Anderson, Dennis C. Dean, Sunil Gupta, Alex Elbrecht, Scott D. Feighner, Dalip J. S. Sirinathsinghji, Joseph P. Arena, Carmen Diaz, Julie A. DeMartino, Mike Dashkevicz, Doris F. Cully, Karen K. McKee, Lex H.T. Van der Ploeg, James M. Schaeffer, Ken K. Liu
Publikováno v:
Science. 273:974-977
Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GP
Publikováno v:
Nature. 364:327-330
GROWTH cones in developing nervous systems encounter a sequence of extracellular cues during migration1,2. In theory, a growth cone can navigate by selectively expressing or activating surface receptor(s) that recognize extracellular cues appropriate
Autor:
Philip S. Paress, James M. Schaeffer, Joseph P. Arena, Keith O. Elliston, Doris F. Cully, Michel J. Hamelin, Demetrios K. Vassilatis, Lex H.T. Van der Ploeg
Publikováno v:
Journal of molecular evolution. 44(5)
Two cDNAs, GluClalpha and GluClbeta, encoding glutamate-gated chloride channel subunits that represent targets of the avermectin class of antiparasitic compounds, have recently been cloned from Caenorhabditis elegans (Cully et al., Nature, 371, 707-7