Capsules, toxins and AtxA as virulence factors of emerging Bacillus cereus biovar anthracis.

Autor: Christophe Brézillon, Michel Haustant, Susann Dupke, Jean-Philippe Corre, Angelika Lander, Tatjana Franz, Marc Monot, Evelyne Couture-Tosi, Gregory Jouvion, Fabian H Leendertz, Roland Grunow, Michèle E Mock, Silke R Klee, Pierre L Goossens

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 4, p e0003455 (2015)

Emerging B. cereus strains that cause anthrax-like disease have been isolated in Cameroon (CA strain) and Côte d'Ivoire (CI strain). These strains are unusual, because their genomic characterisation shows that they belong to the B. cereus species, a

Externí odkaz: https://doaj.org/article/54a687e190e841529dc9d951e15e2a0d

Tetanus Toxin Synthesis is Under the Control of A Complex Network of Regulatory Genes in Clostridium tetani

Autor: Lucile Plourde, Vincent Colombié, Olivier Gorgette, Dominique Garnier, Cecile Deneve, Diana Chapeton-Montes, Christine Schmitt, Holger Brüggemann, Catherine Thouvenot, Fabien Barbirato, Sandy Demay, Michel R. Popoff, Georges Michel Haustant

Publikováno v: Chapeton-Montes, D, Plourde, L, Deneve, C, Garnier, D, Barbirato, F, Colombié, V, Demay, S, Haustant, G, Gorgette, O, Schmitt, C, Thouvenot, C, Brüggemann, H & Popoff, M R 2020, ' Tetanus Toxin Synthesis is Under the Control of A Complex Network of Regulatory Genes in Clostridium tetani ', Toxins, vol. 12, no. 5, 328 . https://doi.org/10.3390/toxins12050328
Toxins
Toxins, MDPI, 2020, 12 (5), pp.328. ⟨10.3390/toxins12050328⟩
Volume 12
Issue 5
Toxins, Vol 12, Iss 328, p 328 (2020)
Toxins, 2020, 12 (5), pp.328. ⟨10.3390/toxins12050328⟩

Clostridium tetani produces a potent neurotoxin, the tetanus toxin (TeNT), which is responsible for an often-fatal neurological disease (tetanus) characterized by spastic paralysis. Prevention is efficiently acquired by vaccination with the TeNT toxo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c9add8fb7e6507c1f40d5a792d247f
https://pure.au.dk/portal/da/publications/tetanus-toxin-synthesis-is-under-the-control-of-a-complex-network-of-regulatory-genes-in-clostridium-tetani(3a664e86-641a-4ce2-931f-5f9635ef8ac9).html

The catalytic domains ofClostridium sordelliilethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid

Autor: Georges Michel Haustant, Serge Pauillac, D. Borden Lacy, Sylviane Hoos, Arnaud Blondel, Alexandre Chenal, Michel R. Popoff, Carolina Varela Chavez, Patrick England

Publikováno v: Cellular Microbiology. 17:1477-1493

Summary Clostridium sordellii lethal toxin (TcsL) is a potent virulence factor belonging to the large clostridial glucosylating toxin family. TcsL enters target cells via receptor-mediated endocytosis and delivers the N-terminal catalytic domain (Tcs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e80f018109f805bdf5e87e44cd04d20
https://doi.org/10.1111/cmi.12449

Identification and Validation of Specific Markers of Bacillus anthracis Spores by Proteomics and Genomics Approaches

Autor: Michel Haustant, Laure Diancourt, François Fenaille, Silke R. Klee, Eric Ezan, Jérôme Chenau, Valérie Caro, Christophe Junot, Pierre L. Goossens, François Becher

Publikováno v: Molecular & Cellular Proteomics. 13:716-732

Bacillus anthracis is the causative bacteria of anthrax, an acute and often fatal disease in humans. The infectious agent, the spore, represents a real bioterrorism threat and its specific identification is crucial. However, because of the high genom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420aaa0bb4c93b13fefc262f7f23d078
https://doi.org/10.1074/mcp.m113.032946

The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation

Autor: Alexandre Chenal, Georges Michel Haustant, Serge Pauillac, Michel-Robert Popoff, Carolina Varela Chavez, Bruno Baron, Patrick England, Arnaud Blondel

Publikováno v: Toxins
Toxins; Volume 8; Issue 4; Pages: 90
Toxins, 2016, 8 (4), pp.90-90. ⟨10.3390/toxins8040090⟩
Toxins, MDPI, 2016, 8 (4), pp.90-90. ⟨10.3390/toxins8040090⟩
Toxins, Vol 8, Iss 4, p 90 (2016)

International audience; Clostridium sordellii lethal toxin (TcsL) is a powerful virulence factor responsible for severe toxic shock in man and animals. TcsL belongs to the large clostridial glucosylating toxin (LCGT) family which inactivates small GT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484a22da38ffbfbf32a344732a71fe5f
http://europepmc.org/articles/PMC4848617