Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Michel Hanocq"'
Publikováno v:
Journal of Pharmaceutical Sciences. 90:1759-1766
The determination of specific kinetic constants ki in pH–profile studies is often undertaken at ambient temperature. However, when dealing with a drug substance that is stable at ambient temperature, the pH–profile study is conducted at a chosen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473a1414480b09186a082d8409966b0c
https://doi.org/10.1002/jps.1125
https://doi.org/10.1002/jps.1125
Publikováno v:
Talanta. 54:983-987
Classical inhibitors of human cytochrome P450 3A4 activity, such as ketoconazol and quercetin, are tested to prove the efficiency of a new metabolisation model using living entire cells. Grapefruit juice is a well-known potent inhibitor of cytochrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e808058e26d3b3e7b15525f881028b90
https://doi.org/10.1016/s0039-9140(01)00368-x
https://doi.org/10.1016/s0039-9140(01)00368-x
Publikováno v:
Carcinogenesis. 22:771-778
The mutagenic properties of UVA are thought to be predominantly radical-mediated, which supposes endogenous sensitizers. In order to investigate a possible role of porphyrins, their synthesis was induced in a murine leukemia P388D1 cell model by trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c92d7ec7c41aa67e59ad6aefc77709d
https://doi.org/10.1093/carcin/22.5.771
https://doi.org/10.1093/carcin/22.5.771
Publikováno v:
Talanta. 48:127-134
Since the induction of putrescine synthesis by ornithine decarboxylase (ODC) is observed in many pathological and physiological processes, a useful and simple method to assay this enzyme activity should be an interesting tool to quantify the biologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca2705a0bb50bfda90637b0d4724b52
https://doi.org/10.1016/s0039-9140(98)00228-8
https://doi.org/10.1016/s0039-9140(98)00228-8
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 706:201-207
An isocratic reversed-phase high-performance liquid chromatography (HPLC) method was developed and validated for separation of testosterone and its main metabolites over the nominal range 20 to 40 microg/ml and 280 to 4600 ng/ml, respectively. Mobile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12ccf1ae03291b6a145db6b76d0b1fe
https://doi.org/10.1016/s0378-4347(97)00565-3
https://doi.org/10.1016/s0378-4347(97)00565-3
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 693:359-366
A reversed-phase HPLC method was developed for the study of isradipine oxidation in vitro. The drug and its main metabolites were determined after extraction from culture media and from h3A4/OR cells having the cytochrome P450 isoenzyme involved in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc2df613d1fa883896fe806d4c5babc2
https://doi.org/10.1016/s0378-4347(97)00048-0
https://doi.org/10.1016/s0378-4347(97)00048-0
Autor:
J. Saint-Germain, M. Van Damme, Michel Hanocq, F. Abi Khalil, J.F. Dauphin, D. Bouzard, P. Mauriac
Publikováno v:
International Journal of Pharmaceutics. 140:1-11
Conventional experimental studies of water/octanol partition at different pHs and concentrations were used to simultaneously evaluate (i) the true P octanol/water partition coefficient, (ii) acidity constants and (iii) extraction constants for ion pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7755ccef7854f7d7dafd1abfa1acbc3d
https://doi.org/10.1016/0378-5173(96)04558-9
https://doi.org/10.1016/0378-5173(96)04558-9
Publikováno v:
Cell Biology and Toxicology. 12:1-9
It has been shown that oxidation of polyamines by polyamine oxidases can produce toxic compounds (H2O2, aldehydes, ammonia) and that the polyamine oxidase-polyamine system is implicated, in vitro, in the death of several parasites. Using Amoeba prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7712eb2d5709ed7187862507358c4515
https://doi.org/10.1007/bf00143389
https://doi.org/10.1007/bf00143389
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 668:189-197
A simple reversed-phase HPLC method was developed for the determination of eight polyamines or monoacetylpolyamines, as their benzoylated derivatives. Interfering products, inherent to the benzoyl chloride derivatization technique (benzoic acid, meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4fb9cbf34e4d9a8c45e6600af8d82a
https://doi.org/10.1016/0378-4347(95)00094-y
https://doi.org/10.1016/0378-4347(95)00094-y
Publikováno v:
Journal of Chromatography A. 662:255-262
A reversed-phase high-performance liquid chromatographic (HPLC) procedure for the determination of chlordiazepoxide, its four metabolites and three unstable photoproducts (oxaziridines) generated by UV irradiation is reported. The influence of pH and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58f2fc754f0a55fbc9b43a62a6753162
https://doi.org/10.1016/0021-9673(94)80513-x
https://doi.org/10.1016/0021-9673(94)80513-x