Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Michel Gilliet"'
Autor:
Anissa Fries, Fanny Saidoune, François Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Interleukin (IL)-26 is a TH17 cytokine with known antimicrobial and pro-inflammatory functions. However, the precise role of IL-26 in the context of pathogenic TH17 responses is unknown. Here we identify a population of blood TH17 intermedia
Externí odkaz:
https://doaj.org/article/9a6badc4e12148d591a4960524014626
Autor:
Feiyang Ma, Olesya Plazyo, Allison C. Billi, Lam C. Tsoi, Xianying Xing, Rachael Wasikowski, Mehrnaz Gharaee-Kermani, Grace Hile, Yanyun Jiang, Paul W. Harms, Enze Xing, Joseph Kirma, Jingyue Xi, Jer-En Hsu, Mrinal K. Sarkar, Yutein Chung, Jeremy Di Domizio, Michel Gilliet, Nicole L. Ward, Emanual Maverakis, Eynav Klechevsky, John J. Voorhees, James T. Elder, Jun Hee Lee, J. Michelle Kahlenberg, Matteo Pellegrini, Robert L. Modlin, Johann E. Gudjonsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin, is incompletely understood. Here we demonstrate, using a combination of single cell and spatial RNA sequencing, IL-36 dependent amplification of IL-17A a
Externí odkaz:
https://doaj.org/article/7d7e27df0a374d5eb3a7f42f1d8c5e5f
Autor:
Laura Yerly, Christine Pich-Bavastro, Jeremy Di Domizio, Tania Wyss, Stéphanie Tissot-Renaud, Michael Cangkrama, Michel Gilliet, Sabine Werner, François Kuonen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The role of reciprocal tumour-stroma interactions in tumour invasion remains poorly characterised. Here, single-cell and spatial transcriptomics identifies the cell populations and their transcriptional reprogramming contributing to the spatial organ
Externí odkaz:
https://doaj.org/article/ea3f55ef4f1f4bc89b960a13a7cc8b39
Autor:
Alessio Mylonas, Heike C. Hawerkamp, Yichen Wang, Jiaqi Chen, Francesco Messina, Olivier Demaria, Stephan Meller, Bernhard Homey, Jeremy Di Domizio, Lucia Mazzolai, Alain Hovnanian, Michel Gilliet, Curdin Conrad
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Rosacea is a common chronic inflammatory skin disease with a fluctuating course of excessive inflammation and apparent neovascularization. Microbial dysbiosis with a high density of Bacillus oleronius and increased activity of kallikrein 5, which cle
Externí odkaz:
https://doaj.org/article/d033bfd462684a7e9f4fe0c374da5b1b
Autor:
Ernest Y. Lee, Changsheng Zhang, Jeremy Di Domizio, Fan Jin, Will Connell, Mandy Hung, Nicolas Malkoff, Veronica Veksler, Michel Gilliet, Pengyu Ren, Gerard C. L. Wong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Amphihelical antimicrobial peptides (AMPs) are bactericidal host defense factors, but their function as immunomodulators is emerging. Here the authors show that several AMPs organize DNA into periodic nanocrystals by self-assembling into superhelical
Externí odkaz:
https://doaj.org/article/0cfa78d072484607acce93542e7e8977
Autor:
Thomas Gruber, Mirela Kremenovic, Hassan Sadozai, Nives Rombini, Lukas Baeriswyl, Fabienne Maibach, Robert L. Modlin, Michel Gilliet, Diego von Werdt, Robert E. Hunger, S. Morteza Seyed Jafari, Giulia Parisi, Gabriel Abril-Rodriguez, Antoni Ribas, Mirjam Schenk
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
Myeloid cells orchestrate the antitumor immune response and influence the efficacy of immune checkpoint blockade (ICB) therapies. We and others have previously shown that IL-32 mediates DC differentiation and macrophage activation. Here, we demonstra
Externí odkaz:
https://doaj.org/article/73102a11a99b4a02ba1d66cddf9d8fe9
Autor:
Curdin Conrad, Jeremy Di Domizio, Alessio Mylonas, Cyrine Belkhodja, Olivier Demaria, Alexander A. Navarini, Anne-Karine Lapointe, Lars E. French, Maxime Vernez, Michel Gilliet
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The pathogenesis of paradoxical psoriasis in patients receiving anti-TNF treatments for classical psoriasis is unclear. Here, the authors show that anti-TNF drugs enhance the production of type I interferon by plasmacytoid dendritic cells, causing sk
Externí odkaz:
https://doaj.org/article/180fc992d72e4fcbbf1d606055e86015
Autor:
Roberto Lande, Raffaella Palazzo, Philippe Hammel, Immacolata Pietraforte, Isabelle Surbeck, Michel Gilliet, Carlo Chizzolini, Loredana Frasca
Publikováno v:
Antibodies, Vol 9, Iss 2, p 14 (2020)
Human cathelicidin LL37 is a cationic antimicrobial peptide active against bacteria and viruses and exerting immune modulatory functions. LL37 can be also a target of autoreactive B- and T-lymphocytes in autoimmune settings. Irreversible post-transla
Externí odkaz:
https://doaj.org/article/70e6c93d50624ba9b30732b600faa03b
Autor:
Stephanie Zwicker, Eva Hattinger, Daniela Bureik, Aleksandra Batycka-Baran, Andreas Schmidt, Peter-Arne Gerber, Simon Rothenfusser, Michel Gilliet, Thomas Ruzicka, Ronald Wolf
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175153 (2017)
IL-1β is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis. Its production is controlled at the transcriptional level and by subsequent posttranslational
Externí odkaz:
https://doaj.org/article/be937ae21d4b4f339eadeb9845c21369
Publikováno v:
Case Reports in Dermatology, Vol 6, Iss 1, Pp 80-84 (2014)
Sebaceous carcinoma (SC) is an uncommon neoplasm manifesting itself either in the eyelid or extraocularly in the head and neck area. Surgery is the standard of care. Irradiation is rarely proposed as monotherapy but is frequently administered as an a
Externí odkaz:
https://doaj.org/article/72c768e42f924cc39cbe800557b2af9d