Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Michel Gilbert"'
Autor:
Janelle Sauvageau, Izel Koyuturk, Frank St. Michael, Denis Brochu, Marie-France Goneau, Ian Schoenhofen, Sylvie Perret, Alexandra Star, Anna Robotham, Arsalan Haqqani, John Kelly, Michel Gilbert, Yves Durocher
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Glycosylation is a key quality attribute that must be closely monitored for protein therapeutics. Established assays such as HILIC-Fld of released glycans and LC-MS of glycopeptides work well for glycoproteins with a few glycosylation sites
Externí odkaz:
https://doaj.org/article/b6b1904909a242f99f4b91f266f9ce1c
Autor:
Grayson Hatfield, Lioudmila Tepliakova, Jessica Tran, Huixin Lu, Michel Gilbert, Roger Y. Tam
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTMonoclonal antibody (mAb) production using non-human cells can introduce non-human glycan epitopes including terminal galactosyl-α1–3-galactose (α1–3-Gal) moieties. Cetuximab is a commercial mAb associated with causing anaphylaxis in so
Externí odkaz:
https://doaj.org/article/6d92f17abccf4bbdafad13f1e090a7ab
Autor:
Maria L. Jaramillo, Traian Sulea, Yves Durocher, Mauro Acchione, Melissa J. Schur, Anna Robotham, John F. Kelly, Marie-France Goneau, Alma Robert, Yuneivy Cepero-Donates, Michel Gilbert
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTEffective processes for synthesizing antibody-drug conjugates (ADCs) require: 1) site-specific incorporation of the payload to avoid interference with binding to the target epitope, 2) optimal drug/antibody ratio to achieve sufficient potency
Externí odkaz:
https://doaj.org/article/d087d6bfdce74a5586de95d8d3bafdd9
Autor:
Florian Cambay, Céline Raymond, Denis Brochu, Michel Gilbert, The Minh Tu, Christiane Cantin, Anne Lenferink, Maxime Grail, Olivier Henry, Gregory De Crescenzo, Yves Durocher
Publikováno v:
Current Research in Immunology, Vol 1, Iss , Pp 23-37 (2020)
The effector functions of the IgGs are modulated by the N-glycosylation of their Fc region. Particularly, the absence of core fucosylation is known to increase the affinity of IgG1s for the Fcγ receptor IIIa expressed by immune cells, in turn transl
Externí odkaz:
https://doaj.org/article/08e98cb3fa604f8f883c571e07d19a71
Autor:
Chantal Mérette, Holly Witteman, Marie-Pierre Gagnon, Annie Leblanc, Patrick Archambault, Richard Fleet, Émilie Dionne, Jean-Pierre Després, Matthew Menear, Michel Gilbert, Antoine Groulx, Marie-Christine Ouellet, Lily Lessard, Annie Vallieres, Marc-André Roy, Catherine Mercier, Caroline Cellard, Marie Baron, Patrick Blouin, George Tarabulsy, Francois Routhier, Marc Hébert, Yves De Koninck, Delphine Collin-Vézina, Nancy Côté, Marie-Hélène Gagné, Maripier Isabelle, Marie-Christine Saint-Jacques, Claudia Savard, Marie-Pier Déry, Éric Gagnon Geneviève Roch, Danielle Nadeau, Julie Tremblay, Marie-Claude Simard Geneviève Dionne, Martin Provencher, Marie-France Demers, Pierre Marquet, Simon Beaulieu-Bonneau Marie-Ève Lamontagne, Normand Boucher, Édith St-Hilaire, Marie-Hélène Morin, Annie Bérubé, Denis Lafortune, Luc Vigneault, Guy Poulin
Publikováno v:
BMJ Open, Vol 12, Iss 4 (2022)
Introduction The COVID-19 pandemic and associated restrictive measures have caused important disruptions in economies and labour markets, changed the way we work and socialise, forced schools to close and healthcare and social services to reorganise.
Externí odkaz:
https://doaj.org/article/83666b09c51e482ab2dbc2783dcc6480
Autor:
Matthew Menear, Ariane Girard, Michèle Dugas, Michel Gervais, Michel Gilbert, Marie-Pierre Gagnon
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Background Collaborative care is an evidence-based approach to improving outcomes for common mental disorders in primary care. Efforts are underway to broadly implement the collaborative care model, yet the extent to which this model promotes person-
Externí odkaz:
https://doaj.org/article/45a041a1e60642f8b2885f9ad2af12a8
Autor:
Annie Aubry, Wei Zou, Evguenii Vinogradov, Dean Williams, Wangxue Chen, Greg Harris, Hongyan Zhou, Melissa J. Schur, Michel Gilbert, Gillian R. Douce, Susan M. Logan
Publikováno v:
Vaccines, Vol 8, Iss 1, p 73 (2020)
Abstract: The BclA3 glycoprotein is a major component of the exosporangial layer of Clostridium difficile spores and in this study we demonstrate that this glycoprotein is a major spore surface associated antigen. Here, we confirm the role of SgtA gl
Externí odkaz:
https://doaj.org/article/1c1b0413725e462bbe605af367d105fa
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124004 (2015)
Molecular mimicry between Campylobacter jejuni lipo-oligosaccharides (LOSs) and human gangliosides GM1 and GD1a induces the production of anti-GM1 and anti-GD1a antibodies, and the development of Guillain-Barré syndrome. Complexes of two different g
Externí odkaz:
https://doaj.org/article/da0486ec318241f29b7e52224a6039c2
Autor:
Maojun Zhang, Michel Gilbert, Nobuhiro Yuki, Fangfang Cao, Jianjun Li, Hongying Liu, Qun Li, Fanliang Meng, Jianzhong Zhang
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131730 (2015)
An outbreak of Guillain-Barré syndrome (GBS), subsequent to Campylobacter jejuni enteritis, occurred in China in 2007. Serum anti-ganglioside antibodies were measured in GBS patients and controls. Genome sequencing was used to determine the phylogen
Externí odkaz:
https://doaj.org/article/48708e2bcdde456a8f54a530e29425c8
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69888 (2013)
Polysialic acids are bioactive carbohydrates found in eukaryotes and some bacterial pathogens. The bacterial polysialyltransferases (PSTs), which catalyze the synthesis of polysialic acid capsules, have previously been identified in select strains of
Externí odkaz:
https://doaj.org/article/8abcc6dff2a54382b28b42a890d6aeaa