Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Michel G Nivard"'
Autor:
Javier de la Fuente, Andrew D Grotzinger, Riccardo E Marioni, Michel G Nivard, Elliot M Tucker-Drob
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010208 (2022)
Recent meta-analyses combining direct genome-wide association studies (GWAS) with those of family history (GWAX) have indicated very low SNP heritability of Alzheimer's disease (AD). These low estimates may call into question the prospects of continu
Externí odkaz:
https://doaj.org/article/8eb6c1e44ff54faea3a7ea2198c62a1d
Autor:
Andrew D. Grotzinger, Javier de la Fuente, Gail Davies, Michel G. Nivard, Elliot M. Tucker-Drob
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
High genetic overlap across traits requires methods that can be used to disentangle shared and unique biological pathways. Here, the authors introduce TSEM, a multivariate method for examining tissue-specific gene expression, and apply it to identify
Externí odkaz:
https://doaj.org/article/01eac78397864e54802d15cf51df6c99
Autor:
Perline A. Demange, Jouke Jan Hottenga, Abdel Abdellaoui, Espen Moen Eilertsen, Margherita Malanchini, Benjamin W. Domingue, Emma Armstrong-Carter, Eveline L. de Zeeuw, Kaili Rimfeld, Dorret I. Boomsma, Elsje van Bergen, Gerome Breen, Michel G. Nivard, Rosa Cheesman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Understanding how parents’ cognitive and non-cognitive skills influence their children’s educational trajectories is important for educational, family and economic policy. Here, the authors investigate parental influence on children’s education
Externí odkaz:
https://doaj.org/article/b96583f4eb514c8e8bce43aae0342a39
Autor:
Oliver Pain, Karen Hodgson, Vassily Trubetskoy, Stephan Ripke, Victoria S. Marshe, Mark J. Adams, Enda M. Byrne, Adrian I. Campos, Tania Carrillo-Roa, Annamaria Cattaneo, Thomas D. Als, Daniel Souery, Mojca Z. Dernovsek, Chiara Fabbri, Caroline Hayward, Neven Henigsberg, Joanna Hauser, James L. Kennedy, Eric J. Lenze, Glyn Lewis, Daniel J. Müller, Nicholas G. Martin, Benoit H. Mulsant, Ole Mors, Nader Perroud, David J. Porteous, Miguel E. Rentería, Charles F. Reynolds, III, Marcella Rietschel, Rudolf Uher, Eleanor M. Wigmore, Wolfgang Maier, Naomi R. Wray, Katherine J. Aitchison, Volker Arolt, Bernhard T. Baune, Joanna M. Biernacka, Guido Bondolfi, Katharina Domschke, Masaki Kato, Qingqin S. Li, Yu-Li Liu, Alessandro Serretti, Shih-Jen Tsai, Gustavo Turecki, Richard Weinshilboum, Andrew M. McIntosh, Cathryn M. Lewis, Siegfried Kasper, Joseph Zohar, Stuart Montgomery, Diego Albani, Gianluigi Forloni, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Manuel Mattheisen, Maciej Trzaskowski, Abdel Abdellaoui, Esben Agerbo, Tracy M. Air, Till F.M. Andlauer, Silviu-Alin Bacanu, Marie Bækvad-Hansen, Aartjan T.F. Beekman, Tim B. Bigdeli, Elisabeth B. Binder, Julien Bryois, Henriette N. Buttenschøn, Jonas Bybjerg-Grauholm, Na Cai, Enrique Castelao, Jane Hvarregaard Christensen, Toni-Kim Clarke, Jonathan R.I. Coleman, Lucía Colodro-Conde, Baptiste Couvy-Duchesne, Nick Craddock, Gregory E. Crawford, Gail Davies, Ian J. Deary, Franziska Degenhardt, Eske M. Derks, Nese Direk, Conor V. Dolan, Erin C. Dunn, Thalia C. Eley, Valentina Escott-Price, Farnush Farhadi Hassan Kiadeh, Hilary K. Finucane, Jerome C. Foo, Andreas J. Forstner, Josef Frank, Héléna A. Gaspar, Michael Gill, Fernando S. Goes, Scott D. Gordon, Jakob Grove, Lynsey S. Hall, Christine Søholm Hansen, Thomas F. Hansen, Stefan Herms, Ian B. Hickie, Per Hoffmann, Georg Homuth, Carsten Horn, Jouke-Jan Hottenga, David M. Hougaard, David M. Howard, Marcus Ising, Rick Jansen, Ian Jones, Lisa A. Jones, Eric Jorgenson, James A. Knowles, Isaac S. Kohane, Julia Kraft, Warren W. Kretzschmar, Zoltán Kutalik, Yihan Li, Penelope A. Lind, Donald J. MacIntyre, Dean F. MacKinnon, Robert M. Maier, Jonathan Marchini, Hamdi Mbarek, Patrick McGrath, Peter McGuffin, Sarah E. Medland, Divya Mehta, Christel M. Middeldorp, Evelin Mihailov, Yuri Milaneschi, Lili Milani, Francis M. Mondimore, Grant W. Montgomery, Sara Mostafavi, Niamh Mullins, Matthias Nauck, Bernard Ng, Michel G. Nivard, Dale R. Nyholt, Paul F. O’Reilly, Hogni Oskarsson, Michael J. Owen, Jodie N. Painter, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Roseann E. Peterson, Wouter J. Peyrot, Giorgio Pistis, Danielle Posthuma, Jorge A. Quiroz, Per Qvist, John P. Rice, Brien P. Riley, Margarita Rivera, Saira Saeed Mirza, Robert Schoevers, Eva C. Schulte, Ling Shen, Jianxin Shi, Stanley I. Shyn, Engilbert Sigurdsson, Grant C.B. Sinnamon, Johannes H. Smit, Daniel J. Smith, Hreinn Stefansson, Stacy Steinberg, Fabian Streit, Jana Strohmaier, Katherine E. Tansey, Henning Teismann, Alexander Teumer, Wesley Thompson, Pippa A. Thomson, Thorgeir E. Thorgeirsson, Matthew Traylor, Jens Treutlein, André G. Uitterlinden, Daniel Umbricht, Sandra Van der Auwera, Albert M. van Hemert, Alexander Viktorin, Peter M. Visscher, Yunpeng Wang, Bradley T. Webb, Shantel Marie Weinsheimer, Jürgen Wellmann, Gonneke Willemsen, Stephanie H. Witt, Yang Wu, Hualin S. Xi, Jian Yang, Futao Zhang, Klaus Berger, Dorret I. Boomsma, Sven Cichon, Udo Dannlowski, E.J.C. de Geus, J. Raymond DePaulo, Enrico Domenici, Tõnu Esko, Hans J. Grabe, Steven P. Hamilton, Andrew C. Heath, Kenneth S. Kendler, Stefan Kloiber, Susanne Lucae, Pamela A.F. Madden, Patrik K. Magnusson, Andres Metspalu, Preben Bo Mortensen, Bertram Müller-Myhsok, Merete Nordentoft, Markus M. Nöthen, Michael C. O’Donovan, Sara A. Paciga, Nancy L. Pedersen, Brenda W.J.H. Penninx, Roy H. Perlis, James B. Potash, Martin Preisig, Catherine Schaefer, Thomas G. Schulze, Jordan W. Smoller, Kari Stefansson, Henning Tiemeier, Henry Völzke, Myrna M. Weissman, Thomas Werge, Douglas F. Levinson, Gerome Breen, Anders D. Børglum, Patrick F. Sullivan
Publikováno v:
Biological Psychiatry Global Open Science, Vol 2, Iss 2, Pp 115-126 (2022)
Background: Antidepressants are a first-line treatment for depression. However, only a third of individuals experience remission after the first treatment. Common genetic variation, in part, likely regulates antidepressant response, yet the success o
Externí odkaz:
https://doaj.org/article/c97a14decdf44013b3e7f514e212f02f
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Estimating direct and indirect effects of genotypes on phenotypes is important for genetic analyses such as Mendelian randomization. Here the authors compare five different methods to estimate direct and indirect genetic effects using summary results
Externí odkaz:
https://doaj.org/article/3b86a242695944458fd715e56be7d963
Autor:
Andrea G. Allegrini, Toos vanBeijsterveldt, Dorret I. Boomsma, Kaili Rimfeld, Jean‐Baptiste Pingault, Robert Plomin, Meike Bartels, Michel G. Nivard
Publikováno v:
JCPP Advances, Vol 2, Iss 3, Pp n/a-n/a (2022)
Abstract Background Comorbidity between psychopathologies may be attributed to genetic and environmental differences between people as well as causal processes within individuals, where one pathology increases risk for another. Disentangling between
Externí odkaz:
https://doaj.org/article/169ef1e92d09452bb5e9f51551a84ee8
Autor:
Hill F. Ip, Camiel M. van der Laan, Eva M. L. Krapohl, Isabell Brikell, Cristina Sánchez-Mora, Ilja M. Nolte, Beate St Pourcain, Koen Bolhuis, Teemu Palviainen, Hadi Zafarmand, Lucía Colodro-Conde, Scott Gordon, Tetyana Zayats, Fazil Aliev, Chang Jiang, Carol A. Wang, Gretchen Saunders, Ville Karhunen, Anke R. Hammerschlag, Daniel E. Adkins, Richard Border, Roseann E. Peterson, Joseph A. Prinz, Elisabeth Thiering, Ilkka Seppälä, Natàlia Vilor-Tejedor, Tarunveer S. Ahluwalia, Felix R. Day, Jouke-Jan Hottenga, Andrea G. Allegrini, Kaili Rimfeld, Qi Chen, Yi Lu, Joanna Martin, María Soler Artigas, Paula Rovira, Rosa Bosch, Gemma Español, Josep Antoni Ramos Quiroga, Alexander Neumann, Judith Ensink, Katrina Grasby, José J. Morosoli, Xiaoran Tong, Shelby Marrington, Christel Middeldorp, James G. Scott, Anna Vinkhuyzen, Andrey A. Shabalin, Robin Corley, Luke M. Evans, Karen Sugden, Silvia Alemany, Lærke Sass, Rebecca Vinding, Kate Ruth, Jess Tyrrell, Gareth E. Davies, Erik A. Ehli, Fiona A. Hagenbeek, Eveline De Zeeuw, Toos C.E.M. Van Beijsterveldt, Henrik Larsson, Harold Snieder, Frank C. Verhulst, Najaf Amin, Alyce M. Whipp, Tellervo Korhonen, Eero Vuoksimaa, Richard J. Rose, André G. Uitterlinden, Andrew C. Heath, Pamela Madden, Jan Haavik, Jennifer R. Harris, Øyvind Helgeland, Stefan Johansson, Gun Peggy S. Knudsen, Pal Rasmus Njolstad, Qing Lu, Alina Rodriguez, Anjali K. Henders, Abdullah Mamun, Jackob M. Najman, Sandy Brown, Christian Hopfer, Kenneth Krauter, Chandra Reynolds, Andrew Smolen, Michael Stallings, Sally Wadsworth, Tamara L. Wall, Judy L. Silberg, Allison Miller, Liisa Keltikangas-Järvinen, Christian Hakulinen, Laura Pulkki-Råback, Alexandra Havdahl, Per Magnus, Olli T. Raitakari, John R. B. Perry, Sabrina Llop, Maria-Jose Lopez-Espinosa, Klaus Bønnelykke, Hans Bisgaard, Jordi Sunyer, Terho Lehtimäki, Louise Arseneault, Marie Standl, Joachim Heinrich, Joseph Boden, John Pearson, L. John Horwood, Martin Kennedy, Richie Poulton, Lindon J. Eaves, Hermine H. Maes, John Hewitt, William E. Copeland, Elizabeth J. Costello, Gail M. Williams, Naomi Wray, Marjo-Riitta Järvelin, Matt McGue, William Iacono, Avshalom Caspi, Terrie E. Moffitt, Andrew Whitehouse, Craig E. Pennell, Kelly L. Klump, S. Alexandra Burt, Danielle M. Dick, Ted Reichborn-Kjennerud, Nicholas G. Martin, Sarah E. Medland, Tanja Vrijkotte, Jaakko Kaprio, Henning Tiemeier, George Davey Smith, Catharina A. Hartman, Albertine J. Oldehinkel, Miquel Casas, Marta Ribasés, Paul Lichtenstein, Sebastian Lundström, Robert Plomin, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors
Externí odkaz:
https://doaj.org/article/882fa84e3ace4249a3c5e7bb582ea021
Autor:
Ben Brumpton, Eleanor Sanderson, Karl Heilbron, Fernando Pires Hartwig, Sean Harrison, Gunnhild Åberge Vie, Yoonsu Cho, Laura D. Howe, Amanda Hughes, Dorret I. Boomsma, Alexandra Havdahl, John Hopper, Michael Neale, Michel G. Nivard, Nancy L. Pedersen, Chandra A. Reynolds, Elliot M. Tucker-Drob, Andrew Grotzinger, Laurence Howe, Tim Morris, Shuai Li, The Within-family Consortium, The 23andMe Research Team, Adam Auton, Frank Windmeijer, Wei-Min Chen, Johan Håkon Bjørngaard, Kristian Hveem, Cristen Willer, David M. Evans, Jaakko Kaprio, George Davey Smith, Bjørn Olav Åsvold, Gibran Hemani, Neil M. Davies
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Family-based study designs have been applied to resolve confounding by population stratification, dynastic effects and assortative mating in genetic association analyses. Here, Brumpton et al. describe theory and simulations for overcoming such biase
Externí odkaz:
https://doaj.org/article/85accda5604c471488ab1aecb46cd352
Autor:
Fiona A. Hagenbeek, René Pool, Jenny van Dongen, Harmen H. M. Draisma, Jouke Jan Hottenga, Gonneke Willemsen, Abdel Abdellaoui, Iryna O. Fedko, Anouk den Braber, Pieter Jelle Visser, Eco J. C. N. de Geus, Ko Willems van Dijk, Aswin Verhoeven, H. Eka Suchiman, Marian Beekman, P. Eline Slagboom, Cornelia M. van Duijn, BBMRI Metabolomics Consortium, Amy C. Harms, Thomas Hankemeier, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Blood metabolite levels are under the influence of environmental and genetic factors. Here, Hagenbeek et al. perform heritability estimations for metabolite measures and determine the contribution of known metabolite loci to metabolite levels using d
Externí odkaz:
https://doaj.org/article/bdd7a85c5d32461f9a054623f04904bd
Autor:
Frank R. Wendt, Miguel Garcia-Argibay, Brenda Cabrera-Mendoza, Unnur A. Valdimarsdóttir, Joel Gelernter, Murray B. Stein, Michel G. Nivard, Adam X. Maihofer, Caroline M. Nievergelt, Henrik Larsson, Manuel Mattheisen, Renato Polimanti, Sandra M. Meier, Karmel W. Choi, Jonathan R.I. Coleman, Nikolaos P. Daskalakis, Christy A. Denckla, Elizabeth Ketema, Rajendra A. Morey, Andrew Ratanatharathorn, Katy Torres, Aliza P. Wingo, Clement C. Zai, Allison E. Aiello, Lynn M. Almli, Ananda B. Amstadter, Soren B. Andersen, Ole A. Andreassen, Paul A. Arbisi, Allison E. Ashley-Koch, S. Bryn Austin, Esmina Avdibegovic, Anders D. Borglum, Dragan Babic, Marie Bækvad-Hansen, Dewleen G. Baker, Jean C. Beckham, Laura J. Bierut, Jonathan I. Bisson, Marco P. Boks, Elizabeth A. Bolger, Bekh Bradley, Meghan Brashear, Gerome Breen, Richard A. Bryant, Angela C. Bustamante, Jonas Bybjerg-Grauholm, Joseph R. Calabrese, Jose Miguel Caldas-de-Almeida, Chia-Yen Chen, Anders M. Dale, Shareefa Dalvie, Jürgen Deckert, Douglas L. Delahanty, Michelle F. Dennis, Seth G. Disner, Katharina Domschke, Laramie E. Duncan, Alma Dzubur Kulenovic, Christopher R. Erbes, Alexandra Evans, Lindsay A. Farrer, Norah C. Feeny, Janine D. Flory, David Forbes, Carol E. Franz, Sandro Galea, Melanie E. Garrett, Aarti Gautam, Bizu Gelaye, Elbert Geuze, Charles F. Gillespie, Aferdita Goci Uka, Scott D. Gordon, Guia Guffanti, Rasha Hammamieh, Michael A. Hauser, Andrew C. Heath, Sian M.J. Hemmings, David Michael Hougaard, Miro Jakovljevic, Marti Jett, Eric Otto Johnson, Ian Jones, Tanja Jovanovic, Xue-Jun Qin, Karen-Inge Karstoft, Milissa L. Kaufman, Ronald C. Kessler, Alaptagin Khan, Nathan A. Kimbrel, Anthony P. King, Nastassja Koen, Henry R. Kranzler, William S. Kremen, Bruce R. Lawford, Lauren A.M. Lebois, Catrin Lewis, Israel Liberzon, Sarah D. Linnstaedt, Mark W. Logue, Adriana Lori, Bozo Lugonja, Jurjen J. Luykx, Michael J. Lyons, Jessica L. Maples-Keller, Charles Marmar, Nicholas G. Martin, Douglas Maurer, Matig R. Mavissakalian, Alexander McFarlane, Regina E. McGlinchey, Katie A. McLaughlin, Samuel A. McLean, Divya Mehta, Rebecca Mellor, Vasiliki Michopoulos, William Milberg, Mark W. Miller, Charles Phillip Morris, Ole Mors, Preben Bo Mortensen, Elliot C. Nelson, Merete Nordentoft, Sonya B. Norman, Meaghan O’Donnell, Holly K. Orcutt, Matthew S. Panizzon, Edward S. Peters, Alan L. Peterson, Matthew Peverill, Robert H. Pietrzak, Melissa A. Polusny, John P. Rice, Victoria B. Risbrough, Andrea L. Roberts, Alex O. Rothbaum, Barbara O. Rothbaum, Peter Roy-Byrne, Kenneth J. Ruggiero, Ariane Rung, Bart P.F. Rutten, Nancy L. Saccone, Sixto E. Sanchez, Dick Schijven, Soraya Seedat, Antonia V. Seligowski, Julia S. Seng, Christina M. Sheerin, Derrick Silove, Alicia K. Smith, Jordan W. Smoller, Scott R. Sponheim, Dan J. Stein, Jennifer S. Stevens, Martin H. Teicher, Wesley K. Thompson, Edward Trapido, Monica Uddin, Robert J. Ursano, Leigh Luella van den Heuvel, Miranda Van Hooff, Eric Vermetten, Christiaan Vinkers, Joanne Voisey, Yunpeng Wang, Zhewu Wang, Thomas Werge, Michelle A. Williams, Douglas E. Williamson, Sherry Winternitz, Christiane Wolf, Erika J. Wolf, Rachel Yehuda, Keith A. Young, Ross McD. Young, Hongyu Zhao, Lori A. Zoellner, Magali Haas, Heather Lasseter, Allison C. Provost, Rany M. Salem, Jonathan Sebat, Richard Shaffer, Tianying Wu, Stephan Ripke, Mark J. Daly, Kerry J. Ressler, Karestan C. Koenen
Publikováno v:
Biological psychiatry, 93(4), 362-369. Elsevier USA
Wendt, F R, Garcia-Argibay, M, Cabrera-Mendoza, B, Valdimarsdóttir, U A, Gelernter, J, Stein, M B, Nivard, M G, Maihofer, A X, Nievergelt, C M, Larsson, H, Mattheisen, M, Polimanti, R, Meier, S M, Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium & Mortensen, P B 2023, ' The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder : A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study ', Biological Psychiatry, vol. 93, no. 4, pp. 362-369 . https://doi.org/10.1016/j.biopsych.2022.08.012
Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium 2023, ' The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder : A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study ', Biological Psychiatry, vol. 93, no. 4, pp. 362-369 . https://doi.org/10.1016/j.biopsych.2022.08.012
Wendt, F R, Garcia-Argibay, M, Cabrera-Mendoza, B, Nivard, M G, Polimanti, R, Mattheisen, M, Meier, S M & Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium 2023, ' The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder : A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study ', Biological psychiatry, vol. 93, no. 4, pp. 362-369 . https://doi.org/10.1016/j.biopsych.2022.08.012
Biological Psychiatry, 93(4), 362-369. Elsevier USA
Wendt, F R, Garcia-Argibay, M, Cabrera-Mendoza, B, Valdimarsdóttir, U A, Gelernter, J, Stein, M B, Nivard, M G, Maihofer, A X, Nievergelt, C M, Larsson, H, Mattheisen, M, Polimanti, R, Meier, S M, Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium & Mortensen, P B 2023, ' The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder : A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study ', Biological Psychiatry, vol. 93, no. 4, pp. 362-369 . https://doi.org/10.1016/j.biopsych.2022.08.012
Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium 2023, ' The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder : A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study ', Biological Psychiatry, vol. 93, no. 4, pp. 362-369 . https://doi.org/10.1016/j.biopsych.2022.08.012
Wendt, F R, Garcia-Argibay, M, Cabrera-Mendoza, B, Nivard, M G, Polimanti, R, Mattheisen, M, Meier, S M & Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium 2023, ' The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder : A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study ', Biological psychiatry, vol. 93, no. 4, pp. 362-369 . https://doi.org/10.1016/j.biopsych.2022.08.012
Biological Psychiatry, 93(4), 362-369. Elsevier USA
Background: Attention-deficit/hyperactivity disorder (ADHD) and posttraumatic stress disorder (PTSD) are associated, but it is unclear if this is a causal relationship or confounding. We used genetic analyses and sibling comparisons to clarify the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb06b6af7206f9c93a5adf8c62d986d
https://doi.org/10.1016/j.biopsych.2022.08.012
https://doi.org/10.1016/j.biopsych.2022.08.012