Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Michel Fosset"'
Autor:
Florian Lesage, Michel Lazdunski, Michel Fosset, M. Ettaiche, Roberto V. Reyes, Inger Lauritzen
Publikováno v:
Neuroscience. 95:893-901
TRAAK is the sole member of the emerging class of 2P domain K+ channels to be exclusively expressed in neuronal cells. TRAAK produces baseline K+ currents which are strongly stimulated by arachidonic acid and by mechanical stretch, and which are inse
Autor:
Michel Fink, Michel Fosset, Michel Lazdunski, Fabrice Duprat, Eric Guillemare, Florian Lesage, Jacques Barhanin, Georges Romey, Catherine Heurteaux
Publikováno v:
Journal of Biological Chemistry. 270:28660-28667
Four cDNA-encoding G-activated inwardly rectifying K+ channels have been cloned recently (Kubo, Y., Reuveny, E., Slesinger, P. A., Jan, Y. N., and Jan, L. Y. (1993) Nature 364, 802-806; Lesage, F., Duprat, F., Fink, M., Guillemare, E., Coppola, T., L
Autor:
Christian Frelin, Georges Romey, Michel Fosset, M. Balerna, Jean-François Renaud, Hugues Schweitz, Jean-Pierre Vincent, R. Chicheportiche, Gilles Ponzio, Jacques Barhanin, M Lazdunski, Alain Lombet, Y. Jacques, J. Pouysségur
Publikováno v:
Neurochemistry international.
This paper describes how neurotoxins specific of the Na(+) channel are used to study its function, its structure and its differentiation in a variety of excitable and non-impulsive cells.
Autor:
Henri Bernardi, Jan de Weille, Bruno Allard, Catherine Heurteaux, Michel Fosset, Eric Honoré, Michel Lazdunski
Publikováno v:
Kidney and Blood Pressure Research. 17:118-120
Autor:
Michel Fosset, Cécile Terrenoire, Norbert Tinel, Christophe Girard, Florian Lesage, Fabrice Duprat, Michel Lazdunski, Georges Romey
Publikováno v:
Biochemical and biophysical research communications. 282(1)
We isolated three novel 2P domain K + channel subunits from human. The first two subunits, TALK-1 and TALK-2, are distantly related to TASK-2. Their genes form a tight cluster of 25 kb on chromosome 6p21.1–p21.2. The corresponding channels produce
Autor:
Virginie Magnone, Eric Honoré, Michel Lazdunski, Amanda Patel, François Maingret, Michel Fosset
Publikováno v:
The Journal of biological chemistry. 275(37)
We cloned human and rat TWIK-2 and expressed this novel 2P domain K(+) channel in transiently transfected COS cells. TWIK-2 is highly expressed in the gastrointestinal tract, the vasculature, and the immune system. Rat TWIK-2 currents are about 15 ti
Autor:
Miguel Salinas, Georges Romey, Florian Lesage, Catherine Heurteaux, Michel Fosset, Michel Lazdunski, Roberto V. Reyes
Publikováno v:
The Journal of biological chemistry. 274(17)
Mouse KCNK6 is a new subunit belonging to the TWIK channel family. This 335-amino acid polypeptide has four transmembrane segments, two pore-forming domains, and a Ca2+-binding EF-hand motif. Expression of KCNK6 transcripts is principally observed in
Publikováno v:
The Journal of biological chemistry. 274(3)
The novel structural class of mammalian channels with four transmembrane segments and two pore regions comprise background K+ channels (TWIK-1, TREK-1, TRAAK, TASK, and TASK-2) with unique physiological functions (1-6). Unlike its counterparts, TRAAK
Autor:
Florian Lesage, Michel Fosset, Roberto V. Reyes, Michel Fink, Fabrice Duprat, Catherine Heurteaux, Michel Lazdunski
Publikováno v:
The EMBO journal. 17(12)
TWIK-1, TREK-1 and TASK K+ channels comprise a class of pore-forming subunits with four membrane-spanning segments and two P domains. Here we report the cloning of TRAAK, a 398 amino acid protein which is a new member of this mammalian class of K+ ch
Publikováno v:
Biochemical and biophysical research communications. 187(2)
Somatostatin inhibition of growth hormone (GH) secretion from adenohypophysis cells in culture was antagonized by the antidiabetic sulfonylurea glipizide (K0.5 = 10 +/- 5 nM). Although all cells that hyperpolarize with somatostatin have ATP-sensitive