A Structural Explanation of the Effects of Dissociated Glucocorticoids on Glucocorticoid Receptor Transactivation

Autor: Pierre Formstecher, Marie-Edith Rafestin-Oblin, Bernadette Masselot, Jérôme Fagart, Michel Fay, Dominique Hetuin, Thierry Idziorek, Xavier Dezitter, Solenne Taront

Publikováno v: Molecular Pharmacology. 85:226-236

There is a therapeutic need for glucocorticoid receptor (GR) ligands that distinguish between the transrepression and transactivation activity of the GR, the later thought to be responsible for side effects. These ligands are known as “dissociated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438d58ed1a7e01a5343e90336b5f8207
https://doi.org/10.1124/mol.113.085860

Mineralocorticoid Receptor Mutations and a Severe Recessive Pseudohypoaldosteronism Type 1

Autor: Raphaël Teissier, Edwige-Ludiwyne Hubert, Fabio L. Fernandes-Rosa, Michel Fay, Marie-Edith Rafestin-Oblin, Maria-Christina Zennaro, Xavier Jeunemaitre, Chantal Metz, Brigitte Escoubet

Publikováno v: Journal of the American Society of Nephrology; Vol 22
Journal of the American Society of Nephrology

Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease of mineralocorticoid resistance characterized by salt wasting and failure to thrive in infancy. Here we describe the first case of a newborn with severe recessive PHA1 caused by two hete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9422febdbd795c6dd94f0c5db481900b

Finerenone impedes aldosterone-dependent nuclear import of the mineralocorticoid receptor and prevents genomic recruitment of steroid receptor coactivator-1

Autor: Marie-Edith Rafestin-Oblin, Peter Kolkhof, Marc Lombès, Alexander Hillisch, Khadija Lamribet, Junaid Ali Khan, Say Viengchareun, Florian Le Billan, Larbi Amazit, Michel Fay, Jérôme Fagart

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, ⟨10.1074/jbc.M115.657957⟩

Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads todeleterious effects on the kidney, blood vessels, and heart. Although steroidal antag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27e1559624d6690df097dcebd813a7e
https://hal.archives-ouvertes.fr/hal-03464100

Glucocorticoid metabolism by 11-β hydroxysteroid dehydrogenase type 2 modulates human mineralocorticoid receptor transactivation activity

Autor: Nicolette Farman, Marie-Edith Rafestin-Oblin, Michel Fay, Françoise Cluzeaud, Brigitte Bocchi, Jérôme Fagart

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 84:239-244

The mineralocorticoid receptor (MR) binds aldosterone, but also glucocorticoid hormones (corticosterone in rodents, cortisol in humans), which largely prevail in the plasma. To prevent permanent and maximal occupancy of MR by glucocorticoid hormones

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b691db6edd13e83c80add66be30275
https://doi.org/10.1016/s0960-0760(03)00036-0

Calcyclin Is an Early Vasopressin-induced Gene in the Renal Collecting Duct

Autor: Sheerazad Boulkroun, Cathy Le Moellic, Nicolette Farman, Brigitte Escoubet, Nathalie Courtois-Coutry, Françoise Cluzeaud, Michel Fay, Marcel Blot-Chabaud

Publikováno v: Journal of Biological Chemistry. 277:25728-25734

Long-term effects of arginine vasopressin (AVP) in the kidney involve the transcription of unidentified genes. By subtractive hybridization experiments performed on the RCCD(1) cortical collecting duct cell line, we identified calcyclin as an early A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1640cb347893585774a3fe270ea1449c
https://doi.org/10.1074/jbc.m112435200