Výsledky vyhledávání - "Michel Dubar"

Sedimentary processes and palaeoenvironments from La Combette sequence (southeastern France): climatic insights on the Last Interglacial/Glacial transition

Autor: Pierre-Jean Texier, Michel Dubar, Louise Purdue, Benjamin Audiard, Carlo Mologni, Sebastian Kreutzer

Publikováno v: Palaeogeography, Palaeoclimatology, Palaeoecology
Palaeogeography, Palaeoclimatology, Palaeoecology, 2021, 576 (30), pp.110503. ⟨10.1016/j.palaeo.2021.110503⟩
Palaeogeography, Palaeoclimatology, Palaeoecology, Elsevier, 2021, 576 (30), pp.110503. ⟨10.1016/j.palaeo.2021.110503⟩

International audience; During the Last Interglacial-Early Glacial transition (MIS5-MIS4; ~73 ka), substantial hydroclimatic changes affected morphogenetic processes, landform dynamics, and ecosystem variability over the Mediterranean sub-alpine vall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5238f73a95ed32afcd83d9197fa9c43c
https://doi.org/10.1016/j.palaeo.2021.110503

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First-in-human trial of the PI3Kβ-selective inhibitor SAR260301 in patients with advanced solid tumors

Autor: Geoffrey I. Shapiro, Michel Dubar, Scott Kopetz, Sandrine Micallef, Jason J. Luke, Dejan Juric, Anna Spreafico, Philippe L. Bedard, Sylvaine Cartot-Cotton, Bin Wu, Keith T. Flaherty, Florent Mazuir, Brigitte Demers, Christelle Castell, Corinne Gomez, Michael A. Davies

Publikováno v: Cancer. 124:315-324

Background Phosphoinositide 3-kinase (PI3K) β is the dominant isoform for PI3K activity in many phosphatase and tensin homolog (PTEN)-deficient tumor models. This was a first-in-human study to determine the maximum tolerated dose, safety, pharmacoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86145f43cf38681f6e6123bcf3885a26
https://doi.org/10.1002/cncr.31044

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Anti-GPVI Fab SAR264565 effectively blocks GPVI function in ex vivo human platelets under arterial shear in a perfusion chamber

Autor: Sebastian Harder, Michel Dubar, Peter Wonerow, Peter Florian, Karina Kuczka, Jochen Graff

Publikováno v: European Journal of Clinical Pharmacology. 73:949-956

Glycoprotein VI (GPVI) is the major platelet receptor for collagen-mediated platelet adhesion and activation. SAR264565 is an anti-GPVI-Fab, binds to GPVI with high affinity, and blocks GPVI function in human platelets in vitro. The effect of SAR2645

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506fe6c997d0294b2e12049034232400
https://doi.org/10.1007/s00228-017-2264-9

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South-eastern Italian transfers towards the Alps during the 5th millennium BCE: Evidence of 'Serra-d'Alto' ware within Square-Mouthed Pottery deposits at the Lare 2 cave (Saint-Benoit, Alpes-de-Haute-Provence, France)

Autor: Jean-Marc Lardeaux, Italo Maria Muntoni, Gilles Durrenmath, Gabriel Monge, Didier Binder, Suzanne Jacomet, Cédric Lepère, Michel Dubar

Publikováno v: Journal of Archaeological Science: Reports
Journal of Archaeological Science: Reports, Elsevier, 2018, 21, pp.222-237. ⟨10.1016/j.jasrep.2018.07.012⟩

International audience; In the framework of the reassessment of the Neolithic Square-Mouthed Pottery series from locus P8, Lare 2 cave (Saint-Benoit, Alpes-de-Haute-Provence, South-eastern France), two sherds were identified as possible replicas or i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b316c302f8a7cfb1cda86f6e1544bc9
https://hal.archives-ouvertes.fr/hal-02353815

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VIII. Région Provence-Alpes-Côte d’Azur

Autor: Michel Dubar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f403969f921001a5141d9a7f561b5eb7
https://doi.org/10.3917/herm.djind.2018.01.0070

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First-in-human trial of the PI3Kβ-selective inhibitor SAR260301 in patients with advanced solid tumors

Autor: Philippe L, Bédard, Michael A, Davies, Scott, Kopetz, Dejan, Juric, Geoffrey I, Shapiro, Jason J, Luke, Anna, Spreafico, Bin, Wu, Christelle, Castell, Corinne, Gomez, Sylvaine, Cartot-Cotton, Florent, Mazuir, Michel, Dubar, Sandrine, Micallef, Brigitte, Demers, Keith T, Flaherty

Publikováno v: Cancer. 124(2)

Phosphoinositide 3-kinase (PI3K) β is the dominant isoform for PI3K activity in many phosphatase and tensin homolog (PTEN)-deficient tumor models. This was a first-in-human study to determine the maximum tolerated dose, safety, pharmacokinetics (PK)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7bee8d85e635b185c7142366f7fa037c
https://pubmed.ncbi.nlm.nih.gov/28976556

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Un habitat perché et fortifié du Ve s. av. n. è. sur le mont Peigros, Sainte-Maxime (Var)

Autor: Michèle Ballinger, Michel Dubar, Philippe Aycard, Jacques Bérato, Sander van der Leeuw, Françoise Audouze, Bui Thi Mai, Philippe Marinval

Publikováno v: Documents d'Archéologie Méridionale. :143-191

Au cours d’un siecle, le Ve av. n.e., qui voit les echanges economiques profondement modifies par le commerce maritime et par l’activite economique des colons grecs de Marseille, l’habitat perche fortifie du Peigros temoigne, par son mobilier,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0448ba105caabcb988c23f55f046c5
https://doi.org/10.4000/dam.6564

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A drug and disease model for lixisenatide, a GLP-1 receptor agonist in type 2 diabetes

Autor: Justin J. Wilkins, Bernard Sébastien, Michel Dubar, Christian Laveille

Publikováno v: The Journal of Clinical Pharmacology. 54:267-278

Incretin hormone analogs such as glucagon-like peptide-1 (GLP-1) receptor agonists have emerged as promising new options for the treatment of type 2 diabetes mellitus (T2DM), targeting several of its pathophysiological traits, including reduced insul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b389556e73ddb90d4db87e7f1942f0f3
https://doi.org/10.1002/jcph.192

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