Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michel Dominguez"'
Autor:
Philippe G. Cammisotto, Moise Bendayan, Alain Sané, Michel Dominguez, Carole Garofalo, Émile Levy
Publikováno v:
International Journal of Cell Biology, Vol 2010 (2010)
Gastric Leptin is absorbed by duodenal enterocytes and released on the basolateral side towards the bloodstream. We investigated in vitro some of the mechanisms of this transport. Caco-2/15 cells internalize leptin from the apical medium and release
Externí odkaz:
https://doaj.org/article/b706666dfe05417588a113978f4165a0
Autor:
François A. Leblond, Edgard Delvin, Louis-Philippe Precourt, Nabil G. Seidah, Emile Levy, Michel Dominguez
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G805-G815
Proprotein convertase subtilisin/kexin type 9 (PCSK9) posttranslationally promotes the degradation of the low-density lipoprotein receptor (LDLr) in hepatocytes and increases plasma LDL cholesterol. It is not clear, however, whether PCSK9 plays a rol
Autor:
Amit Choudhury, Michel Dominguez, Vishwajeet Puri, Deepak K. Sharma, Keishi Narita, Christine L. Wheatley, David L. Marks, Richard E. Pagano
Publikováno v:
Journal of Clinical Investigation. 109:1541-1550
Autor:
Raman Deep Singh, David L. Marks, Jennifer C. Brown, Michel Dominguez, Christine L. Wheatley, Vishwajeet Puri, Richard E. Pagano, Rikio Watanabe
Publikováno v:
The Journal of Cell Biology
Sphingolipids (SLs) are plasma membrane constituents in eukaryotic cells which play important roles in a wide variety of cellular functions. However, little is known about the mechanisms of their internalization from the plasma membrane or subsequent
Publikováno v:
Journal of Biological Chemistry. 276:26492-26498
Glucosylceramide synthase (GCS) transfers glucose from UDP-Glc to ceramide, catalyzing the first glycosylation step in the formation of higher order glycosphingolipids. The amino acid sequence of GCS was reported to be dissimilar from other proteins,
Publikováno v:
Traffic. 1:807-815
In this review, we summarize our studies of membrane lipid transport in sphingolipid storage disease (SLSD) fibroblasts. We recently showed that several fluorescent SL analogs were internalized from the plasma membrane predominantly to the Golgi comp
Autor:
Jacques Paiement, Michel Dominguez, John J.M. Bergeron, Sophie Dahan, Christine Lavoie, Jennifer N. Gushue, Line Roy
Publikováno v:
The Journal of Cell Biology
A two-step reconstitution system for the generation of ER cargo exit sites from starting ER-derived low density microsomes (LDMs; 1.17 g/cc) is described. The first step is mediated by the hydrolysis of Mg(2+)ATP and Mg(2+)GTP, leading to the formati
Autor:
Alejandro Claude, Paul Melançon, Ali Fazel, Jacque Lovell, Sophie Dahan, Louis Hermo, Michel Dominguez, John J.M. Bergeron
Publikováno v:
The Journal of Cell Biology
A well-characterized cell-free assay that reconstitutes Golgi transport is shown to require physically fragmented Golgi fractions for maximal activity. A Golgi fraction containing large, highly stacked flattened cisternae associated with coatomer-ric
Autor:
Olivier Gingras, Anil Vachani, William N. Rom, Rene Allard, Pui Yee Fong, Leroy Hood, Paul Kearney, Scott M. Law, Heather Butler, Pierre P. Massion, Julie Lamontagne, Nathan D. Price, Stephen W. Hunsucker, Xiao-Jun Li, Daniel Chelsky, Michael Schirm, Michel Dominguez, Kenneth C. Fang, Harvey I. Pass, Stephen Lam, Lik Wee Lee, Clive Hayward, Matthew McLean
Publikováno v:
Science translational medicine. 5(207)
Each year, millions of pulmonary nodules are discovered by computed tomography and subsequently biopsied. Because most of these nodules are benign, many patients undergo unnecessary and costly invasive procedures. We present a 13-protein blood-based
Autor:
Carole Garofalo, Philippe G. Cammisotto, Alain T. Sané, Michel Dominguez, Moise Bendayan, Emile Levy
Publikováno v:
International Journal of Cell Biology, Vol 2010 (2010)
International Journal of Cell Biology
International Journal of Cell Biology
Gastric Leptin is absorbed by duodenal enterocytes and released on the basolateral side towards the bloodstream. We investigated in vitro some of the mechanisms of this transport. Caco-2/15 cells internalize leptin from the apical medium and release