Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Michel Cyr"'
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Sphingosine-1-phosphate (S1P) is a potent bioactive lipid mediator that acts as a natural ligand upon binding to five different receptors that are located in astrocytes, oligodendrocytes, microglial and neuronal cells. Recently, global activation of
Externí odkaz:
https://doaj.org/article/b4b21897ae5543cd8a1b5b6ac6156e0b
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150220 (2016)
Externí odkaz:
https://doaj.org/article/85d8565d239c4bf4b46f6403b36b5720
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 1, Pp 645-655 (2012)
Pharmacological dopamine replacement with l-3,4-dihydroxyphenylalanine (l-DOPA) remains the most effective approach to treat the motor symptoms of Parkinson's disease (PD). However, as the disease progresses, the therapeutic response to l-DOPA gradua
Externí odkaz:
https://doaj.org/article/3081419efd5247deadc8e809741ca34e
Publikováno v:
Neurobiology of Disease, Vol 38, Iss 1, Pp 59-67 (2010)
l-3,4-dihydroxyphenylalanine methyl ester hydrochloride (l-DOPA) is the gold standard for symptomatic treatment of Parkinson's disease (PD), but long-term therapy is associated with the emergence of abnormal involuntary movements (AIMS) known as l-DO
Externí odkaz:
https://doaj.org/article/eb0f3cb794824b788b7671410a3f559c
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86988 (2014)
Recently, striatal-enriched protein tyrosine phosphatase (STEP) and its upstream regulator protein kinase A (PKA) have been suspected to play a role in the intracellular mechanisms of fear conditioning and spatial memory. However, whether they contri
Externí odkaz:
https://doaj.org/article/b8a57492c581469d978bb8c671c7c6ca
Autor:
Marie-Elaine Laurier-Laurin, Audrée De Montigny, Suzanne Attiori Essis, Michel Cyr, Guy Massicotte
Publikováno v:
Neural Plasticity, Vol 2014 (2014)
The lysosomal acid ceramidase, an enzyme known to limit intracellular ceramide accumulation, has been reported to be defective in neurodegenerative disorders. We show here that rat hippocampal slices, preincubated with the acid ceramidase inhibitor (
Externí odkaz:
https://doaj.org/article/f0f0bac33f5048ed9896d74b27abb4d2
Publikováno v:
Neural Plasticity, Vol 2013 (2013)
The molecular mechanisms that regulate Tau phosphorylation are complex and currently incompletely understood. In the present study, pharmacological inhibitors were deployed to investigate potential processes by which the N-methyl-D-aspartate (NMDA) s
Externí odkaz:
https://doaj.org/article/4af97a6887ae4f38aadd7f7a0dce041b
Publikováno v:
Neural Plasticity, Vol 2010 (2010)
Physiological activation of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors has been proposed to play a key role in both neuronal cell function and dysfunction. In the present study, we used selective NMDA receptor antagonists to inves
Externí odkaz:
https://doaj.org/article/3074dee4450741bca9e6d1b68f01e758
Autor:
Yan Bergeron, Guy Massicotte, Élise Pépin, Michel Cyr, Bruno Ouimet, Jean-Martin Beaulieu, Laure Chagniel
Publikováno v:
Behavioral Neuroscience. 133:135-143
Akt protein family (Akt1, Akt2 and Akt3) of serine/threonine kinases, also known as protein kinase B, are enzymes implicated in many physiological and pathological processes in the central nervous system. A striking feature of these enzymes is their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb7a9bd49abb54204f8ce98ef58f66b
https://doi.org/10.1037/bne0000292
https://doi.org/10.1037/bne0000292