γ-Alkynyl oxime cyclization: an easy route to a new heteropolyring: 3a,8a-butano-3a,8a-dihydro-3H-benzo[4,5]furo[2,3-b]pyrrole-1-oxide

Autor: Michel Coquillay, J. L. Avril, Bernard Marcot, Colette De Rango, Henri Moskowitz, Joëlle Mayrargue

Publikováno v: New Journal of Chemistry. 23:743-748

Hydroxylamine reacts with 2-(2,3-dimethoxyphenyl)-2-propynylcyclohexanone 1 and leads, not to the expected oxime, but to a N-hydroxyaminonitrone 5, according to a reverse-Cope or a 1,3-azaprotiocyclotransfer (APT) mechanism. The deprotection of the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea400340e6ef9a9e46be82d7bf091ac4
https://doi.org/10.1039/a901896d

Alkylation of manganese(ii) tetraphenylporphyrin by a synthetic antimalarial trioxane

Autor: Jean-François Berrien, Olivier Provot, Joëlle Mayrargue, Michel Coquillay, Liliane Cicéron, Frédérick Gay, Martin Danis, Anne Robert, Bernard Meunier

Publikováno v: Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2003, 1 (16), pp.2859. ⟨10.1039/b302835f⟩
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2003, 1 (16), pp.2859. ⟨10.1039/b302835f⟩

International audience; The synthesis and the antimalarial activity of a new kind of polycyclic 1,2,4-trioxanes are reported. The alkylation of the heme model Mn II TPP by the biologically active (IC 50 = 320 nmolL-1) hemiperketal 2 is presented.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94703f7f0ab37d6ecf9e5ef19d611bd5
https://hal.science/hal-02394634/document