Výsledky vyhledávání - "Michel Binoux"

Insulin-like growth factor binding protein-3 increases intracellular calcium concentrations in MCF-7 breast carcinoma cells

Autor: Jean-Marc Ricort, Claudine Lassarre, Alain Lombet, Michel Binoux

Publikováno v: FEBS Letters. 527:293-297

Insulin-like growth factor binding protein-3, IGFBP-3, specifically binds to IGFs with high affinity, but it is also capable of modulating the IGF-I signalling pathway or inducing apoptosis independently of its binding to IGFs. The molecular mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6eb228a02eeabb977c65c2c5a4dc00
https://doi.org/10.1016/s0014-5793(02)03250-7

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Insulin-like Growth Factor-binding Protein-3 Activates a Phosphotyrosine Phosphatase

Autor: Michel Binoux, Jean-Marc Ricort

Publikováno v: Journal of Biological Chemistry. 277:19448-19454

The proliferative action of insulin-like growth factors (IGF-I and -II) is mediated via the type I IGF receptor (IGF-IR) and is modulated by their association with high affinity binding proteins, IGFBP-1 to -6. We recently found that, in addition to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d25bb0b8d619b92234568e639fe93d1
https://doi.org/10.1074/jbc.m200439200

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The amino-terminal region of insulin-like growth factor binding protein-3, 1–95IGFBP-3, induces apoptosis of MCF-7 breast carcinoma cells

Autor: Michel Binoux, Laurence Bernard, Sylvie Babajko, Jean-Marc Ricort

Publikováno v: Biochemical and Biophysical Research Communications. 293:55-60

In an earlier study, we reported that an N-terminal proteolytic fragment ((1-95)IGFBP-3) corresponding to the first 95 residues of human insulin-like growth factor binding protein-3 (IGFBP-3) inhibits proliferation in a variety of fibroblasts. With a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d21ad4d94338c06fcee6120a214981f
https://doi.org/10.1016/s0006-291x(02)00181-x

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Use of the Ligand Immunofunctional Assay for Human Insulin-Like Growth Factor (IGF) Binding Protein-3 (IGFBP-3) to Analyze IGFBP-3 Proteolysis and IGF-I Bioavailability in Healthy Adults, GH-Deficient and Acromegalic Patients, and Diabetics1

Autor: Françoise Duron, Claudine Lassarre, Michel Binoux

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 86:1942-1952

The ligand immunofunctional assay for plasma insulin-like growth factor (IGF) binding protein (IGFBP)-3 developed in our laboratory provides for specific measurement of intact, as opposed to proteolyzed, IGFBP-3. IGFBP-bound IGFs are dissociated and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3092950a96e620826296f6b0a85def74
https://doi.org/10.1210/jcem.86.5.7467

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Measurement of Intact Insulin-Like Growth Factor-Binding Protein-3 in Human Plasma Using a Ligand Immunofunctional Assay1

Autor: Michel Binoux, Claudine Lassarre

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 86:1260-1266

Limited proteolysis of insulin-like growth factor binding protein-3 (IGFBP-3) is a fundamental mechanism in the regulation of IGF-I bioavailability in the bloodstream. Its measurement by Western immunoblotting provides only semiquantitative estimatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecc272ac1b414f586a38e1b5966cd428
https://doi.org/10.1210/jcem.86.3.7362

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Insulin-Like Growth Factor (IGF) Binding Protein-3 Inhibits Type 1 IGF Receptor Activation Independently of Its IGF Binding Affinity**This work was supported by the Institut National de la Santé et de la Recherche Médicale and the University of Paris VI

Autor: Jean-Marc Ricort, Michel Binoux

Publikováno v: Endocrinology. 142:108-113

Insulin-like growth factor binding proteins (IGFBPs) regulate the cellular actions of the IGFs owing to their strong affinities, which are equal to or stronger than the affinity of the type 1 IGF receptor (IGF-IR), the mediator of IGF signal transduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::742e484bd491af4590cef677e9e212bc
https://doi.org/10.1210/endo.142.1.7915

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Impaired brain development and hydrocephalus in a line of transgenic mice with liver-specific expression of human insulin-like growth factor binding protein-1

Autor: Sophie Doublier, Michel Binoux, Danielle Seurin, C. Duyckaerts

Publikováno v: Growth Hormone & IGF Research. 10:267-274

Insulin-like growth factors (IGFs) produced in the brain are known to participate in brain development via activation of the type 1 IGF receptor. IGF binding proteins (IGFBPs) modulate the cellular action of IGFs and some are expressed in the fetal b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9258221fceb08056ccf1bc9070baa2
https://doi.org/10.1054/ghir.2000.0168

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Glomerulosclerosis in mice transgenic for human insulin-like growth factor-binding protein-1

Autor: Liliane J. Striker, Gary E. Striker, Danielle Seurin, Marie-Christine Verpont, Michel Binoux, Sophie Doublier, Bruno Fouqueray, Laurent Baud, Patrice Callard

Publikováno v: Kidney International. 57(6):2299-2307

Glomerulosclerosis in mice transgenic for human insulin-like growth factor-binding protein-1. Background The growth hormone (GH)/insulin-like growth factor (IGF) system is thought to participate in the glomerulosclerosis process. Because IGF-binding

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