Zobrazeno 1 - 10
of 397
pro vyhledávání: '"Michel Baudry"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Intracellular lysosomal trafficking and positioning are fundamental cellular processes critical for proper neuronal function. Among the diverse array of proteins involved in regulating lysosomal positioning, the Transient Receptor Potential Mucolipin
Externí odkaz:
https://doaj.org/article/7408e75fbe78424aaeff934435c732f6
Autor:
Michel Baudry, Yubin Wang, Xiaoning Bi, Yun Lyna Luo, Zhijun Wang, Zeechan Kamal, Alexander Shirokov, Ed Sullivan, Dennis Lagasca, Hany Khalil, Gary Lee, Kathy Fosnaugh, Philippe Bey, Shujaath Mehdi, Greg Coulter
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 2, Pp n/a-n/a (2024)
Abstract Our laboratory has shown that calpain‐2 activation in the brain following acute injury is directly related to neuronal damage and the long‐term functional consequences of the injury, while calpain‐1 activation is generally neuroprotect
Externí odkaz:
https://doaj.org/article/6f9db8b3fcb74ef09bea457d69a31b76
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Angelman syndrome (AS) is a rare neurogenetic disorder caused by UBE3A deficiency and characterized by severe developmental delay, cognitive impairment, and motor dysfunction. In the present study, we performed RNA-seq on hippocampal samples
Externí odkaz:
https://doaj.org/article/8794acc8643b40888b8e60d0d2a670a9
Autor:
Michel Baudry, Xiaoning Bi
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
In 1984, Gary Lynch and Michel Baudry published in Science a novel biochemical hypothesis for learning and memory, in which they postulated that the calcium-dependent protease, calpain, played a critical role in regulating synaptic properties and the
Externí odkaz:
https://doaj.org/article/eea116ad80cf40669d25fede74f0fcc7
Publikováno v:
Neural Plasticity, Vol 2022 (2022)
Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by severe developmental delay, motor impairment, language and cognition deficits, and often with increased seizure activity. AS is caused by deficiency of UBE3A, which is both
Externí odkaz:
https://doaj.org/article/688ca4aaf69d4952829292549b3a7281
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
While calpains have been implicated in neurogenesis for a long time, there is still little information regarding the specific contributions of various isoforms in this process. We took advantage of the availability of mutant mice with complete deleti
Externí odkaz:
https://doaj.org/article/42bc4899b864469c938c2cd1ea8c0b3b
Publikováno v:
Neurobiology of Disease, Vol 147, Iss , Pp 105149- (2021)
Calpain has been proposed to play a critical role in the development of epilepsy. Here we used conditional calpain-2 knock-out (C2CKO) mice in a C57/Bl6 background and a selective calpain-2 inhibitor to analyze the role of calpain-2 in epilepsy. Neur
Externí odkaz:
https://doaj.org/article/77c40b6d012a433790ab8b2d462367f0
Publikováno v:
BBA Advances, Vol 1, Iss , Pp 100004- (2021)
Calpain-1 knock-out (KO) mice exhibit enhanced susceptibility to neurodegeneration due to the lack of the neuroprotective function of calpain-1. Dicer has been shown to play a fundamental role in the biogenesis of most miRNAs. Here, we identified 45
Externí odkaz:
https://doaj.org/article/849b624e206643079bd48e30bcb07549
Autor:
Wenyue Su, Qian Zhou, Yubin Wang, Athar Chishti, Qingshun Q. Li, Sujay Dayal, Shayan Shiehzadegan, Ariel Cheng, Clare Moore, Xiaoning Bi, Michel Baudry
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Calpains represent a family of calcium-dependent proteases participating in a multitude of functions under physiological or pathological conditions. Calpain-1 is one of the most studied members of the family, is ubiquitously distributed in organs and
Externí odkaz:
https://doaj.org/article/108e7f94e7654a5e91346c4b717c5ea5
Autor:
Michel Baudry
Publikováno v:
Neural Plasticity, Vol 2020 (2020)
Neural Plasticity is pleased to announce the appointment of Dr. Michel Baudry as its new Chief Editor. Dr. Baudry is currently University Professor at Western University of Health Sciences in Pomona, CA. In this Editorial, Dr. Baudry describes some o
Externí odkaz:
https://doaj.org/article/d2a1e8795f4d45188f01b6fccf1de3aa