Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Michel Awwad"'
Autor:
Scott Fountain, Carol Cronenberger, Cho-Ming Loi, Eugenia Kraynov, Michel Awwad, Martin E. Dowty, Owen Fields, Susan Hurst, Steven W. Martin, Bing Kuang, Odette A. Fahmi, Diane Wang
Publikováno v:
Drug Metabolism and Disposition. 39:1779-1783
Increasing use of therapeutic proteins (TPs) in polypharmacy settings calls for more in-depth understanding of the biological interactions that can lead to increased toxicity or loss of pharmacological effect. Factors such as patient population, medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be9070e963bae4805e883fa9f2a4e1e0
https://doi.org/10.1124/dmd.111.040808
https://doi.org/10.1124/dmd.111.040808
Autor:
Davinder Gill, David Wensel, Michel Awwad, Lioudmila Tchistiakov, Pam Szklut, Xin Xu, Yulia Vugmeyster, Garvin Warner, John Ross
Publikováno v:
Pharmaceutical Research. 28:1696-1706
Anti-Aβ Ab2 (Ab2) is a humanized monoclonal antibody against amino acids 3-6 of primate (but not rodent) amyloid β (Aβ) and is being evaluated for the treatment of Alzheimer's disease (AD). This study was conducted to predict the human pharmacokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7869e1675391b8e80abf23f52a3b54ab
https://doi.org/10.1007/s11095-011-0405-x
https://doi.org/10.1007/s11095-011-0405-x
Autor:
Karoline Bechtold-Peters, Jeffrey T. Blue, Hanns-Christian Mahler, Mary E.M. Cromwell, Michel Awwad, Satish K. Singh, Thomas Spitznagel, Doug P. Nesta, Danny K. Chou, Hans-Juergen Krause, Nataliya Afonina, Brian K. Meyer, Linda O. Narhi
Publikováno v:
Journal of Pharmaceutical Sciences. 99:3302-3321
Concern around the lack of monitoring of proteinaceous subvisible particulates in the 0.1-10 microm range has been heightened (Carpenter et al., 2009, J Pharm Sci 98: 1202-1205), primarily due to uncertainty around the potential immunogenicity risk f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da6cbebd9afebc1062b8e250b485ee8
https://doi.org/10.1002/jps.22097
https://doi.org/10.1002/jps.22097
Autor:
Cassandra Long, Peter Yeh, Frank Sun, Mohamed Ezzelarab, David K. C. Cooper, Hidetaka Hara, Nicolai V. Bovin, Michel Awwad, David Ayares, Koji Tomiyama
Publikováno v:
Xenotransplantation. 17:197-206
Yeh P, Ezzelarab M, Bovin N, Hara H, Long C, Tomiyama K, Sun F, Ayares D, Awwad M, Cooper DKC. Investigation of potential carbohydrate antigen targets for human and baboon antibodies. Xenotransplantation 2010; 17: 197–206. © 2010 John Wiley & Sons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76a7ae8d2ec83a2e1744d2995c92bbf4
https://doi.org/10.1111/j.1399-3089.2010.00579.x
https://doi.org/10.1111/j.1399-3089.2010.00579.x
Autor:
David K. C. Cooper, Richard N. Pierson, Jorg Dieter Seebach, Mark H. Yazer, Michael A. Rees, Anthony Dorling, David Ayares, Hideki Ohdan, Michel Awwad
Publikováno v:
Transplantation. 84:1-7
The ability to genetically engineer pigs that no longer express the Galalpha1,3Gal (Gal) oligosaccharide has been a significant step toward the clinical applicability of xenotransplantation. Using a chronic immunosuppressive regimen based on costimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::129ab4e072ddc49d83744b7a72a17635
https://doi.org/10.1097/01.tp.0000260427.75804.f2
https://doi.org/10.1097/01.tp.0000260427.75804.f2
Autor:
Zuhaib Ibrahim, Xiaocheng Zhu, Michel Awwad, Yih Jyh Lin, Hidetaka Hara, David Ayares, Pleunie P. M. Rood, David K. C. Cooper, Mohamed Ezzelarab, Adriana Zeevi, Suyapa Ball, Jamie Busch
Publikováno v:
Xenotransplantation. 13:357-365
Background: The availability of pigs homozygous for α1,3-galactosyltransferase gene-knockout (GT-KO) has enabled study of the incidence and cytotoxicity of primate antibodies directed to antigens other than Galα1,3Gal (Gal), termed non-Gal antigens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f46bb0bec72be16e1c2b1a1c27b697
https://doi.org/10.1111/j.1399-3089.2006.00319.x
https://doi.org/10.1111/j.1399-3089.2006.00319.x
Autor:
Megan Sykes, Hideki Ohdan, Yong-Guang Yang, A. Thall, David Ryan, Michel Awwad, Huw S. Kruger-Grey, D. Harper, C Wu, Y. Xu
Publikováno v:
Transplantation. 81:940-948
Background. Anti-Gal antibodies cause hyperacute and delayed xenograft rejection in pig-to-primate transplantation. The cell populations producing anti-Gal and other natural antibodies in primates are unknown. Methods. Cells from different lymphoid c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74330e502a8cfb4435390c4e1c3575a6
https://doi.org/10.1097/01.tp.0000203300.87272.a3
https://doi.org/10.1097/01.tp.0000203300.87272.a3
Autor:
David K. C. Cooper, Jamie Busch, Hidetaka Hara, Suyapa Ball, Mohamed Ezzelarab, Xiaocheng Zhu, Michel Awwad, David Ayares, Pleunic P. M. Rood
Publikováno v:
Transplant International. 19(2):158-165
The recent availability of pigs homozygous for alpha1,3-galactosyltransferase gene-knockout (GT-KO) has enabled the study of incidence and cytotoxicity of antibodies of cynomolgus monkeys directed to antigens other than Galalpha1,3Gal (Gal), termed n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92b6364ae0b4abfc401b2d9eedb6822
https://pure.eur.nl/en/publications/b566b103-c939-418f-b138-8a4edb387efa
https://pure.eur.nl/en/publications/b566b103-c939-418f-b138-8a4edb387efa
Autor:
Stuart L. Houser, David K. C. Cooper, Frank J. M. F. Dor, Yau Lin Tseng, Yosuke Hisashi, Kazuhiko Yamada, David H. Sachs, Michel Awwad, Henk Jan Schuurman, Akira Shimizu, Kenji Kuwaki, Simon C. Robson
Publikováno v:
Transplantation, 10, 1493-1500. Lippincott Williams & Wilkins
Background. The recent generation of α1,3-galactosyltransferase gene-knockout (GalT-KO) pigs has allowed investigation of the survival of GalT-KO pig organs in nonhuman primates. Methods. Heterotopic heart transplantation from GalT-KO pigs was carri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ec19902f70f432d8548aa6ab7a2afb
https://doi.org/10.1097/01.tp.0000181397.41143.fa
https://doi.org/10.1097/01.tp.0000181397.41143.fa
Autor:
Kazuhiko Yamada, Courtney J. Lancos, David K. C. Cooper, Akira Shimizu, Yau Lin Tseng, David H. Sachs, Frank J. M. F. Dor, Henk-Jan Schuurman, Jane Cheng, Robert J. Hawley, Michel Awwad, K Moran, T.M. Sanderson
Publikováno v:
Transplantation. 78:15-20
Background. The expression of galactoseal,3galactose (Gal) in pigs has proved a barrier to xenotransplantation Miniature swine lacking Gal (Gal -/- pigs) have been produced by nuclear transfer/embryo transfer. Methods. The tissues of five Gal -/- pig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02eb0b6a37dfced525bbd6e3d9acae4
https://doi.org/10.1097/01.tp.0000130487.68051.eb
https://doi.org/10.1097/01.tp.0000130487.68051.eb