Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michel Vanmarsenille"'
Autor:
Mark A. Pietz, Michael M. Murray, Michael E. Kopach, Thierry Giard, Thierry Defrance, Utpal K. Singh, Vincent Mancuso, Michel Vanmarsenille, Gregory A. Stephenson, William G. Trankle, Kobierski Michael Edward, Mindy B. Forst
Publikováno v:
Organic Process Research & Development. 13:209-224
A commercial synthesis was developed for the production of (4-benzylmorpholin-2-(S)-yl)-(tetrahydropyran-4-yl)methanone mesylate, 1a, a key starting material for a phase 2, new investigational drug candidate at Eli Lilly and Company. The target compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59ea8393476d33dcd3c13cfa6038449d
https://doi.org/10.1021/op800247w
https://doi.org/10.1021/op800247w
Autor:
Jean-Pierre Van Hoeck, Anne Mockel, Hugo Gorissen, Alfio Borghese, Pascal Boquel, Luc Antoine, Michel Vanmarsenille, Vincent Mancuso, Alain Merschaert
Publikováno v:
Tetrahedron Letters. 47:8285-8288
We have developed a new synthesis of 3,4-disubstituted-1,2,5-thiadiazoles. The methodology is based on the ring opening of readily available 3,4-dichloro-1,2,5-thiadiazole with metal amides to afford a stable synthon, which is then transformed into t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe1780472d53f243eb1a352eefe3f45
https://doi.org/10.1016/j.tetlet.2006.09.102
https://doi.org/10.1016/j.tetlet.2006.09.102
Autor:
Napora Freddy Andre, Khalid Diker, Laurent Delhaye, Alain Merschaert, Daniel Giraud, Michel Vanmarsenille, Pieter Delbeke, Willy Brione, Vincent Mancuso, Jean-Paul Kestemont
Publikováno v:
Tetrahedron Letters. 44:4531-4534
A stereoselective approach has been developed for the synthesis of cis- and trans-2-methyl-4-arylpiperidines from a common intermediate. The Ni-catalyzed hydrogenolysis of N-Boc-2-methyl-4-aryl-4-piperidinols, obtained by addition of organometallic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690ac0f5c765d7266f32d8736d642897
https://doi.org/10.1016/s0040-4039(03)01021-9
https://doi.org/10.1016/s0040-4039(03)01021-9
Autor:
David R. Dobson, Joel Y. Lienard, Louise Haughton, Susan K. Hemrick-Luecke, Peter Thaddeus Gallagher, Manuel Javier Cases-Thomas, Andrew James Ledgard, Jeremy Findlay, Linda K. Thompson, Campbell Gordon Iain, Benjamin Bonnier, Craig White, Thierry Defrance, John R. Boot, John Joseph Masters, Thierry Giard, Michel Vanmarsenille, Vincent Mancuso, Magnus Wilhelm Walter, Nancy Dezutter, Sivi Ouwerkerk-Mahadevan, Lorna Hayhurst, Francoise J. Brunelle, Camy A. Herbots
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(7)
A novel series of tertiary alcohol containing 2-substituted benzyl morpholines have been discovered as potent and selective inhibitors of the norepinephrine transporter. Efficient synthetic routes were developed featuring a highly diastereoselective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9280be57b188a183ceb3ba484608838
https://pubmed.ncbi.nlm.nih.gov/16413778
https://pubmed.ncbi.nlm.nih.gov/16413778
Autor:
Michael E. Kopach, Utpal K. Singh, Michael E. Kobierski, William G. Trankle, Michael M. Murray, Mark A. Pietz, Mindy B. Forst, Gregory A. Stephenson, Vincent Mancuso, Thierry Giard, Michel Vanmarsenille, Thierry DeFrance
Publikováno v:
Organic Process Research & Development; Mar2009, Vol. 13 Issue 2, p209-224, 16p