Zobrazeno 1 - 10
of 356
pro vyhledávání: '"Michel, Zwaan"'
Autor:
Abdelrahman H. Elsayed, Xueyuan Cao, Richard J. Marrero, Nam H. K. Nguyen, Huiyun Wu, Yonhui Ni, Raul C. Ribeiro, Herold Tobias, Peter J. Valk, François Béliveau, Guillaume Richard-Carpentier, Josée Hébert, C. Michel Zwaan, Alan Gamis, Edward Anders Kolb, Richard Aplenc, Todd A. Alonzo, Soheil Meshinchi, Jeffrey Rubnitz, Stanley Pounds, Jatinder K. Lamba
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract In this study, we leveraged machine-learning tools by evaluating expression of genes of pharmacological relevance to standard-AML chemotherapy (ara-C/daunorubicin/etoposide) in a discovery-cohort of pediatric AML patients (N = 163; NCT001360
Externí odkaz:
https://doaj.org/article/8d2e5546c18f4cf3998b81a1211405a0
Autor:
Eline J. M. Bertrums, Jurrian K. de Kanter, Lucca L. M. Derks, Mark Verheul, Laurianne Trabut, Markus J. van Roosmalen, Henrik Hasle, Evangelia Antoniou, Dirk Reinhardt, Michael N. Dworzak, Nora Mühlegger, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Bianca F. Goemans, Ruben van Boxtel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Therapy-related myeloid neoplasms (t-MN) arise as a complication of chemo- and/or radiotherapy. Although t-MN can occur both in adult and childhood cancer survivors, the mechanisms driving therapy-related leukemogenesis likely vary across di
Externí odkaz:
https://doaj.org/article/133d1d021aba4ed18ed60a7266e30b7f
Autor:
Milad Rasouli, Selina Troester, Florian Grebien, Bianca F. Goemans, C. Michel Zwaan, Olaf Heidenreich
Publikováno v:
HemaSphere, Vol 8, Iss 9, Pp n/a-n/a (2024)
Abstract Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a heterogeneous molecular landscape. In the pediatric context, the NUP98 gene is a frequent target of chromosomal rearrangements that are linked to poor prognosis an
Externí odkaz:
https://doaj.org/article/67cdf313c7f94694b4e56c30c64b1c07
Autor:
Kirsten A. Thus, Hester A. de Groot-Kruseman, Pauline Winkler-Seinstra, Marta Fiocco, Heidi Segers, Cor van den Bos, Inge M. van der Sluis, Wim J.E. Tissing, Margreet A. Veening, Christian Michel Zwaan, Cornelis M. van Tilburg, Rob Pieters, Marc Bierings
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Infections lead to substantial morbidity during treatment of acute lymphoblastic leukemia (ALL) in which the adaptive immune system gets severely affected, leading to declining serum immunoglobulin levels. The aim of this trial was to investigate whe
Externí odkaz:
https://doaj.org/article/634bb1c123c8458d9d413f68bd657421
Autor:
Judith M. Boer, Uri Ilan, Aurélie Boeree, Karin P. S. Langenberg, Jan Koster, Marco J. Koudijs, Jayne Y. Hehir‐Kwa, Stefan Nierkens, Corinne Rossi, Jan J. Molenaar, Bianca F. Goemans, Monique L. denBoer, C. Michel Zwaan
Publikováno v:
HemaSphere, Vol 8, Iss 7, Pp n/a-n/a (2024)
Abstract Over the past 10 years, institutional and national molecular tumor boards have been implemented for relapsed or refractory pediatric cancer to prioritize targeted drugs for individualized treatment based on actionable oncogenic lesions, incl
Externí odkaz:
https://doaj.org/article/cc8777c8974245468114f51e19691ae4
Autor:
Naomi Michels, Femke M. Hormann, Aurélie Boeree, Edwin Sonneveld, Anthony V. Moorman, Gabriele Escherich, Rosemary Sutton, H. Berna Beverloo, Rob Pieters, C. Michel Zwaan, Monique L. den Boer, Judith M. Boer
Publikováno v:
EJC Paediatric Oncology, Vol 3, Iss , Pp 100140- (2024)
Background: Chromosome 21 is affected in ∼60% of paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) patients and includes somatic and constitutional gains, intrachromosomal amplification of chromosome 21 (iAMP21), and the transloca
Externí odkaz:
https://doaj.org/article/ecb1e835fb504ce692dbd72007e10a05
Publikováno v:
Haematologica, Vol 109, Iss 6 (2024)
The treatment of childhood acute lymphoblastic leukemia (ALL) has reached overall survival rates exceeding 90%. The present and future challenges are to cure the remainder of patients still dying from disease, and to reduce morbidity and mortality in
Externí odkaz:
https://doaj.org/article/58e8158c7a55463297ae468119ed2442
Autor:
Joost B. Koedijk, Thomas B. van Beek, Marijn A. Vermeulen, Lennart A. Kester, Elizabeth K. Schweighart, Stefan Nierkens, Mirjam E. Belderbos, C. Michel Zwaan, Katja M. J. Heitink-Pollé, Olaf Heidenreich
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Regression of leukemia in the absence of disease-modifying therapy remains poorly understood, although immunological mechanisms are thought to play a role. Here, we present a unique case of a 17-year-old boy with immune dysregulation and long-lasting
Externí odkaz:
https://doaj.org/article/b1ef9090fbca46babb653538dcd1bab1
Autor:
Judith M. Boer, Uri Ilan, Babette D.J. Hoen, Aurelie Boeree, Karin P.S. Langenberg, Jan Koster, Jean-Pierre Bourquin, Jan J. Molenaar, Bianca Goemans, Monique L. den Boer, Michel Zwaan
Publikováno v:
HemaSphere, Vol 7, p e0856830 (2023)
Externí odkaz:
https://doaj.org/article/244bc693337145f391575e94f7ae4fc6
Autor:
Joost Koedijk, Inge van der Werf, Marijn Vermeulen, Alicia Perzolli, Marta Fiocco, Hester de Groot-Kruseman, Rubina Moeniralam, Stefan Nierkens, Mirjam Belderbos, Michel Zwaan, Olaf Heidenreich
Publikováno v:
HemaSphere, Vol 7, p e8730026 (2023)
Externí odkaz:
https://doaj.org/article/fc444c9a6611445c8aa1ad2da08c4412