Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michel, Pelat"'
Autor:
Patrice Bellevergue, Klaus Steinmeyer, Michel Pelat, Suzanne Marque, John Weston, Nils Rackelmann, Jean-Michel Guillon, Petra Arndt, Thomas Lartigue, Philip Janiak, Veronique Ballet, Gary Mccort, Laetitia Ly-Nguyen, Frédérique Chézalviel-Guilbert, Heinz Gögelein, Fabrice Barbe, Marie-Pierre Pruniaux-Harnist, Georges Tavares, Cyril Daveu, Marc Trellu, Laurence Lucats, Philippe Beauverger, Klaus Wirth
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 377:293-304
In failing hearts, Na+/Ca2+ exchanger (NCX) overactivity contributes to Ca2+ depletion, leading to contractile dysfunction. Inhibition of NCX is expected to normalize Ca2+ mishandling, to limit afterdepolarization-related arrhythmias, and to improve
Autor:
Jean-Pierre Bidouard, Fabrice Barbe, Bruno Poirier, Philippe Beauverger, Philip Janiak, Frédéric Petit, Paul J. Schaeffer, Marie-Laure Ozoux, Michel Pelat, Véronique Briand, Jean-Michel Guillon, Jean-Michel Altenburger
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:24-37
Chronic kidney disease (CKD) remains a common disorder, leading to growing health and economic burden without curative treatment. In diabetic patients, CKD may result from a combination of metabolic and nonmetabolic-related factors, with mortality ma
Autor:
Michel, Pelat, Fabrice, Barbe, Cyril, Daveu, Laetitia, Ly-Nguyen, Thomas, Lartigue, Suzanne, Marque, Georges, Tavares, Véronique, Ballet, Jean-Michel, Guillon, Klaus, Steinmeyer, Klaus, Wirth, Heinz, Gögelein, Petra, Arndt, Nils, Rackelmann, John, Weston, Patrice, Bellevergue, Gary, McCort, Marc, Trellu, Laurence, Lucats, Philippe, Beauverger, Marie-Pierre, Pruniaux-Harnist, Philip, Janiak, Frédérique, Chézalviel-Guilbert
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 377(2)
In failing hearts, Na
Autor:
Michel Pelat, Irina Lobysheva, Jean-Luc Balligand, Bernard Gallez, Olivier Feron, Fanny Desjardins, Chantal Dessy
Publikováno v:
Cardiovascular Research. 79:527-536
AIMS: In endothelial cells, caveolin-1 (cav-1) is known to negatively modulate the activation of endothelial nitric oxide synthase, a key regulator of blood pressure (BP). However, the impact of genetic alteration of cav-1 on vascular nitric oxide (N
Autor:
Amy M. Shah, Xiangzhen Sui, Vinciane Gaussin, Michel Pelat, Nadia Hedhli, Hongyu Qiu, Chull Hong, Audrey Ginion, Thomas Wagner, Stephen F. Vatner, Luc Bertrand, Li Wang, Christophe Depre
Publikováno v:
Circulation Research. 98:280-288
Ischemic preconditioning confers powerful protection against myocardial infarction through pre-emptive activation of survival signaling pathways, but it remains difficult to apply to patients with ischemic heart disease, and its effects are transient
Publikováno v:
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 142:144-150
The mammalian heart expresses all three isoforms of nitric oxide synthases (NOS) in diverse cell types of the myocardium. Despite their apparent promiscuity, the NOS isoforms support specific signaling because of their subcellular compartmentation wi
Autor:
John K. Bielicki, Ann Mertens, Rozenn Quarck, Nora Benhabiles, Jean-Luc Balligand, Michel Pelat, Javier Ganame, Mike Mackness, Dieuwke De Keyzer, Wim Verreth, Gérard Marguerie, Ewa Ninio, Bharti Mackness, Peter Verhamme, Marie-Christine Herregods, Paul Holvoet
Publikováno v:
Circulation. 110:3259-3269
Background— Weight loss in obese insulin-resistant but not in insulin-sensitive persons reduces coronary heart disease risk. To what extent changes in gene expression are related to atherosclerosis and cardiovascular function is unknown. Methods an
Autor:
Jean-Luc Balligand, Michel Pelat
Publikováno v:
Seminars in Vascular Medicine. 4:367-375
Hypertension and dyslipidemia are frequently associated as risk factors for cardiovascular diseases. Statins are among the most potent drugs to correct hypercholesterolemia, and their use across a wide range of cardiovascular risk levels significantl
Autor:
Olivier Feron, Pierre Sonveaux, Michel Pelat, Philippe Ghisdal, Julie DeWever, Chantal Dessy, Jean-Luc Balligand, Philippe Martinive, Vincent Grégoire, Zuzana Batova, Géraldine Daneau
Publikováno v:
Circulation Research. 95:154-161
Nitric oxide (NO) is a powerful angiogenic mediator acting downstream of vascular endothelial growth factor (VEGF). Both the endothelial NO synthase (eNOS) and the VEGFR-2 receptor colocalize in caveolae. Because the structural protein of these signa
Autor:
Michel Galinier, Verwaerde P, Jean-Michel Senard, Atul Pathak, Pierre Philip-Couderc, Fatima Smih, Michel Pelat, Cyril Vidal, Philippe Rouet, Sophie Buys
Publikováno v:
Hypertension. 41:414-421
Obesity is associated with volumetric arterial hypertension and with early increase in heart rate and decreased heart rate variability. The consequences of obesity-related hypertension on heart gene regulation are poorly known and were investigated i