Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Michel, Journet"'
Autor:
Mark A. Hatcher, Michel Journet, Shiping Xie, John A. Kowalski, Tom C Lovelace, Greg A. Erickson, Christopher J. Pink
Publikováno v:
The Journal of organic chemistry. 87(4)
A novel oxidative activation of a thiolactam was developed for the preparation of methyltriazolo[1,4]benzodiazepine in a single step. A sulfenic acid (R-SOH) was proposed as the activated intermediate with the concurrent formation of acetylhydrazone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea0bdda36c075d125208a1318cdb95e
https://pubmed.ncbi.nlm.nih.gov/33876939
https://pubmed.ncbi.nlm.nih.gov/33876939
Autor:
Bernie O’Hare, Glynn D. Williams, Elie A. Tabet, Peng Liu, Matthew A. Toczko, Charles E. Wade, Neil R. Curtis, Michael Tolar Martin, Michel Journet, David C. Leitch, Charles A. Goss, Tony Shaw, Anna L. Dunn
Publikováno v:
Organometallics. 38:129-137
The iodination of 4-fluoro-2-(trifluoromethyl)benzonitrile via C–H lithiation and subsequent treatment with iodine under continuous flow conditions is described. Screening identified both LDA and PhLi as effective bases, giving the desired 3-iodo r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3d2eab15c627c2bc2aee4e4c317f3c4
https://doi.org/10.1021/acs.organomet.8b00538
https://doi.org/10.1021/acs.organomet.8b00538
Autor:
Ayman Allian, Timothy M. Braden, Suzanne M. Opalka, J. Christopher McWilliams, Michel Journet, Scott A. May
Publikováno v:
Organic Process Research & Development. 22:1143-1166
This manuscript provides the results of an in-depth survey assessment of the capabilities, experience, and perspectives on continuous processing in the pharmaceutical sector, with respondents from both pharmaceutical companies and Contract Manufactur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183dd3efd5fc77ec24ceecc70a2cd3c0
https://doi.org/10.1021/acs.oprd.8b00160
https://doi.org/10.1021/acs.oprd.8b00160
Autor:
Michel JOURNET
Michel Journet offre une perspective à la fois personnelle et historique sur les évolutions de l'agriculture.L'auteur, au- delà du parcours de la famille dans l'entre Beauce et Perche, retrace 2 siècles d'évolution du monde rural par la voie sur
Publikováno v:
Organic Letters. 18:1812-1815
An asymmetric synthesis of a silicon-containing proline surrogate, N-Boc-(R)-silaproline (1), is described. Starting from N-Boc-dehydroalanine ester, deprotonation, followed by N-alkylation with chloromethyldimethylsilane under flow conditions, affor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db9b3a8b53f61effb4080082068ab54
https://doi.org/10.1021/acs.orglett.6b00548
https://doi.org/10.1021/acs.orglett.6b00548
Autor:
Michel Journet, Zhihui Peng, Dalian Zhao, Arlene E. Mckeown, Guy R. Humphrey, Jeffrey T. Kuethe
Publikováno v:
Organic Process Research & Development. 20:227-232
A highly efficient, regioselective five-step synthesis of the TRPV1 antagonist 1 is described. The coupling of piperazine 7 with dichloropyrimidine 8 proceeded via a regioselective Pd-mediated amination affording product 11 in excellent yield. Conver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ff56dfdcc1dda616fbcb2bfe14089a9
https://doi.org/10.1021/acs.oprd.5b00388
https://doi.org/10.1021/acs.oprd.5b00388
Autor:
Jeremy P. Scott, Gavin W. Stewart, Carl A. Baxter, Michel Journet, Birgit Kosjek, Kevin M. Belyk, Lushi Tan, Jaume Balsells, Hongmei Li, Mahbub Alam, Christopher Wise, Cheng-yi Chen, Zhiguo Jake Song
Publikováno v:
Organic Letters. 17:1533-1536
A practical asymmetric synthesis of the complex fused bis-macrocyclic HCV protease inhibitor MK-6325 (1) is described. Through the combination of a high yielding and low catalyst loading ring-closing metathesis (RCM) to forge the 15-membered macrocyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19eceb81f8f069dd4828b6930195a860
https://doi.org/10.1021/acs.orglett.5b00418
https://doi.org/10.1021/acs.orglett.5b00418
Autor:
Diane Bilodeau, Claude Léveillé, E. Loing, Michel Journet, Marie Laure Oula, Eric Dupont, Juan Gomez
Publikováno v:
Clinical, Cosmetic and Investigational Dermatology
Eric Dupont,1 Michel Journet,2 Marie-Laure Oula,3 Juan Gomez,1 Claude Léveillé,4 Estelle Loing,5 Diane Bilodeau6 1Immanence IDC Inc, Québec, QC, Canada; 2Clinique de Dermatologie St-Joseph, Montréal, QC, Canada; 3Evalulab Inc, Mont-Royal, QC, Can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c7da206cab1301774caed34089837e
http://europepmc.org/articles/PMC3933246
http://europepmc.org/articles/PMC3933246
Publikováno v:
The Journal of organic chemistry. 81(21)
The development of a practical asymmetric total synthesis of the potent HIV-1 integrase inhibitor 5 is described. Key transformations include construction of the naphthridine core in a highly efficient manner followed by cyclization of the 8-membered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0022d1cb7de8be3c562b4530d5b1d35
https://pubmed.ncbi.nlm.nih.gov/27471910
https://pubmed.ncbi.nlm.nih.gov/27471910
Autor:
Ian W. Davies, Paul N. Devine, Robert A. Reamer, David M. Tschaen, Fei Zhang, Daniel Zewge, Jeffrey T. Kuethe, David R. Lieberman, Zhihui Peng, Kevin M. Belyk, David M. Tellers, Guy R. Humphrey, Peter G. Dormer, Michel Journet, Andrew Nolting, Marjorie S. Waters, Dalian Zhao, Zhiguo J. Song
Publikováno v:
The Journal of Organic Chemistry. 76:7804-7815
Development of a practical synthesis of MK-7009, a 22-membered macrocycle, is described. A variety of ring-closing strategies were evaluated, including ring-closing metathesis, intermolecular palladium-catalyzed cross-couplings, and macrolactamizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1dc6683cb1f9b4cbaa077ffc9b2d32f
https://doi.org/10.1021/jo2011494
https://doi.org/10.1021/jo2011494