Pharmaco-fUS for Characterizing Drugs for Alzheimer’s Disease – The Case of THN201, a Drug Combination of Donepezil Plus Mefloquine

Autor: Benjamin Vidal, Marine Droguerre, Marco Valdebenito, Luc Zimmer, Michel Hamon, Franck Mouthon, Mathieu Charvériat

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in Alzheimer’s disease (AD). Beyond the widely described neuronal impact of donepezil, it was recently shown that targeting connexins, the

Externí odkaz: https://doaj.org/article/f1673f49cb2843cbbeed8d10c46d6f94

5-Hydroxytryptamine receptors in GtoPdb v.2023.1

Autor: Frank Yocca, Carlos M. Villalon, Andrew Sleight, Trevor Sharp, Pramod R. Saxena, Bryan Roth, John A. Peters, Stephen J. Peroutka, John Neumaier, Ewan Mylecharane, Derek N. Middlemiss, Graeme R. Martin, Luc Maroteaux, Klaus Peter Latté, Patrick P. A. Humphrey, Daniel Hoyer, Rebecca Hills, Katharine Herrick-Davis, Julie Hensler, René Hen, Paul R. Hartig, Michel Hamon, Mark Hamblin, Manfred Göthert, Richard M. Eglen, Aline Dumuis, Marlene L. Cohen, Amy Butler, Theresa Branchek, Joel Bockaert, Gordon Baxter, Nicholas M. Barnes, Rodrigo Andrade

Publikováno v: IUPHAR/BPS Guide to Pharmacology CITE. 2023

5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [198] and subsequently revised [180]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4af4d3d745f0e8e57bd57986ad25334a
https://doi.org/10.2218/gtopdb/f1/2023.1

An Obituary to Jacques Glowinski (1936–2020)

Autor: Michel Hamon, Bernard Scatton, Jean-Antoine Girault

Publikováno v: Journal of Neurochemistry. 158:818-820

This is an obituary of Dr. Jacques Glowinski (1936-2020), one of the last « giants » of Neuropharmacology trained in the sixties in the laboratory of Julius Axelrod (Nobel Prize in 1970). He was a founding father of this discipline in France and hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88454b24f8c9fce8ee0b4477e896349b
https://doi.org/10.1111/jnc.15273

Key role of the 5-HT 1A receptor addressing protein Yif1B in serotonin neurotransmission and SSRI treatment

Autor: Jorge Diaz, Craig A. Stockmeier, Justine Masson, Vincent Martin, Laurence Lanfumey, Michel Hamon, Lionel Mathieu, Jeanine Alterio, Haysam Salman, Caroline Chevarin, Mark C. Austin, Michèle Darmon

Publikováno v: Journal of Psychiatry and Neuroscience
Journal of Psychiatry and Neuroscience, Canadian Medical Association, 2020, 45 (5), pp.344-355. ⟨10.1503/jpn.190134⟩
J Psychiatry Neurosci

International audience; Altered function of serotonin receptor 1A (5-HT1AR) has been consistently implicated in anxiety, major depressive disorder and resistance to antidepressants. Mechanisms by which the function of 5-HT1AR (expressed as an autorec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0ffc0152902bfe27a235c5bf77531a
https://hal.sorbonne-universite.fr/hal-02989883/document

Assessment of 5-HT7 Receptor Agonists Selectivity Using Nociceptive and Thermoregulation Tests in Knockout versus Wild-Type Mice

Autor: Alex Brenchat, Maria Rocasalbas, Daniel Zamanillo, Michel Hamon, José Miguel Vela, Luz Romero

Publikováno v: Advances in Pharmacological Sciences, Vol 2012 (2012)

No study has ever examined the effect of 5-HT7 receptor agonists on nociception by using 5-HT7 receptor knockout mice. Basal sensitivity to noxious heat stimuli and formalin-induced nociception in both phase I and II of the formalin test did not diff

Externí odkaz: https://doaj.org/article/5fe69b43098e4d90ba875983bdbdbd44