Differential Regulation of Peroxisome Proliferator-Activated Receptor (PPAR)-α1 and Truncated PPARα2 as an Adaptive Response to Fasting in the Control of Hepatic Peroxisomal Fatty Acid β-Oxidation in the Hibernating Mammal

Autor: Mustapha Cherkaoui-Malki, Norbert Latruffe, Mostafa Kabine, Zakaria El Kebbaj, Michel Dauça, M'Hammed Saïd El Kebbaj, Pierre Andreoletti, Driss Mountassif, Hervé Schohn

Publikováno v: Endocrinology
Endocrinology, Endocrine Society, 2009, 150 (3), pp.1192-201. 〈10.1210/en.2008-1394〉
Endocrinology, 2009, 150 (3), pp.1192-201. ⟨10.1210/en.2008-1394⟩

Seasonal obesity and fasting-associated hibernation are the two major metabolic events governing hepatic lipid metabolism in hibernating mammals. In this process, however, the role of the nuclear receptor known as peroxisome proliferator-activated re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5e358486afd68fa0bd528522e98787
https://doi.org/10.1210/en.2008-1394

Importance de l’activation des PPARgamma dans la pharmacologie de la rigidité artérielle

Autor: Jeffrey Atkinson, I. Lartaud, Virginie Gaillard, Michel Dauça

Publikováno v: Annales Pharmaceutiques Françaises. 65:189-194

Resume Avec l’âge, les vaisseaux deviennent plus sensibles au stress oxydant et a l’inflammation, responsables d’alterations fonctionnelles et structurales comme l’arteriosclerose. Cette derniere se caracterise par un remodelage et une rigid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fdbfd64797b0c04c6f074c135d1452e
https://doi.org/10.1016/s0003-4509(07)90035-8

Decrease of human hepatoma cell growth by arachidonic acid is associated with an accumulation of derived products from lipid peroxidation

Autor: Etienne Dewailly, Christian Slomianny, Hervé Gautier, Philippe Becuwe, Arnaud Bianchi, Michel Dauça, Jean-Louis Merlin

Publikováno v: Biochimie. 86:633-642

We showed that the metabolism of arachidonic acid (AA) in HepG2 cells generates reactive oxygen species (ROS), which activate the p38 mitogen-activated protein kinase (MAPK) pathway and the redox-sensitive transcription factors AP-1 and NF-kappaB, le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d530585b0be2cbc9df8130dad70f1a2
https://doi.org/10.1016/j.biochi.2004.09.011

Arachidonic acid activates a functional AP-1 and an inactive NF-κB complex in human HepG2 hepatoma cells

Autor: Arnaud Bianchi, Muriel Barberi-Heyob, Céline Didelot, Philippe Becuwe, Michel Dauça

Publikováno v: Free Radical Biology and Medicine. 35:636-647

Exogenous arachidonic acid (AA) has been shown to induce the antioxidant manganese superoxide dismutase gene by reactive oxygen species (ROS) derived from AA metabolism and the participation of the p38 mitogen-activated protein kinase (MAPK) pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19f2591cdf760c1806d5e9b4dd2ebc7
https://doi.org/10.1016/s0891-5849(03)00387-3

Expression of peroxisome proliferator-activated receptors alpha and gamma in differentiating human colon carcinoma Caco-2 cells

Autor: Michel Dauça, Cécile Huin, Renée Hatier, François Plénat, Laurent Antunes, Marc Bentejac, Hervé Schohn, Maurice Bugaut

Publikováno v: Biology of the Cell. 94:15-27

The expression of peroxisome proliferator-activated receptors alpha (PPARalpha) and gamma (PPARgamma) was studied in the human adenocarcinoma Caco-2 cells induced to differentiate by long term culture (15 days). The differentiation of Caco-2 cells wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f1652cfab79a399ffeb82adf7059b6
https://doi.org/10.1016/s0248-4900(01)01178-9