Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Michel, Chartrain"'
Autor:
Michel Chartrain
Publikováno v:
Vaccine Development and Manufacturing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f98680f4344c10ab31196e745536701
https://doi.org/10.1002/9781118870914.ch2
https://doi.org/10.1002/9781118870914.ch2
Autor:
Michel Chartrain, Olivier Cochet
Publikováno v:
médecine/sciences. 25:1078-1084
Discovering and designing novel therapeutic monoclonal antibodies (mAb) is just the beginning. In order to support clinical evaluations and to reach the market place, rapid and cost effective production platforms are needed. Process development and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd9443dfdfe8f45c78f82ffe0515d04f
https://doi.org/10.1051/medsci/200925121078
https://doi.org/10.1051/medsci/200925121078
Publikováno v:
Biocatalysis and Biotransformation. 27:107-117
The presence of high concentrations of substrate or product may impede the optimal functioning of a biocatalyst, more so in the case of whole cell biocatalysts where the metabolic status of the cells may be compromised. In this article we investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bb5844fa99ea2db0425d99def8ae32c
https://doi.org/10.1080/10242420802539046
https://doi.org/10.1080/10242420802539046
Publikováno v:
Biotechnology Progress. 21:1038-1047
For many microbial fermentation processes, the inoculum train can have a substantial impact on process performance in terms of productivity, profitability, and process control. In general, it is understood that a well-characterized and flexible inocu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfbb32345957b18bb578cafb87cc56b
https://doi.org/10.1021/bp040041p
https://doi.org/10.1021/bp040041p
Autor:
J. Okonkowski, Kristin M. Listner, P. Salmon, Laura Kizer Bentley, Beth Junker, Michel Chartrain, A. Caparoni, R. Wnek, C. Kistler, David K. Robinson
Publikováno v:
Biotechnology Progress. 22:1335-1345
With the applications of DNA vaccines extending from infectious diseases to cancer, achieving the most efficient, reproducible, robust, scalable, and economical production of clinical grade plasmid DNA is paramount to the medical and commercial succe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3507ffa971d7f2139d244e4059495585
https://doi.org/10.1021/bp060046h
https://doi.org/10.1021/bp060046h
Publikováno v:
Tetrahedron. 60:781-788
In this paper an isolated NADH dependent ketone reductase has been used to synthesise (S)-6-bromo-β-tetralol from 6-bromo-β-tetralone, together with commercially available formate dehydrogenase (FDH) as a recycle enzyme to produce preparative quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::520b077f001fbb4a46036833ecaf3cf3
https://doi.org/10.1016/j.tet.2003.11.060
https://doi.org/10.1016/j.tet.2003.11.060
Autor:
SW Drew, Christopher J. Hewitt, A Amanullah, John M. Woodley, Michel Chartrain, Barry C. Buckland, C Lee, Alvin W. Nienow
Publikováno v:
Biotechnology and Bioengineering. 81:405-420
The bionconversion of indene to cis-(1S,2R)-indandiol, a potential key intermediate in the synthesis of Merck's HIV protease inhibitor, CRIXIVAN™, can be achieved using Rhodococcus, Pseudomonas putida, and Escherichia coli strains. This study repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99425d22168c82d55077da7519b3d62
https://doi.org/10.1002/bit.10479
https://doi.org/10.1002/bit.10479
Autor:
Alvin W. Nienow, C Lee, Christopher J. Hewitt, John M. Woodley, Michel Chartrain, Barry C. Buckland, SW Drew, A Amanullah
Publikováno v:
Enzyme and Microbial Technology. 31:954-967
The bioconversion of indene to cis -(1 S ,2 R ) indandiol, a key intermediate in the synthesis of Merck’s HIV protease inhibitor, CRIXIVAN™ can be achieved during the growth of a Rhodococcus strain. In a previous study, we reported on the applica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ab4afb72eef4441dec43410c2c2f556
https://doi.org/10.1016/s0141-0229(02)00183-7
https://doi.org/10.1016/s0141-0229(02)00183-7
Autor:
A Amanullah, C Lee, Alvin W. Nienow, Barry C. Buckland, SW Drew, John M. Woodley, Michel Chartrain, Christopher J. Hewitt
Publikováno v:
Biotechnology and Bioengineering. 80:239-249
The bioconversion of indene to cis-(1S,2R) indandiol, a potential key intermediate in the synthesis of Merck's HIV protease inhibitor, CRIXIVAN™, can be achieved using a Rhodococcus strain. This study using Rhodococcus I24 reports on the applicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8000291ad394457064189607f282ac75
https://doi.org/10.1002/bit.10477
https://doi.org/10.1002/bit.10477
Autor:
Louis Matty, Kozo Gbewonyo, Wenjie Li, Hu Essa H, Paul J. Reider, Michel Chartrain, Daniel R. Sidler, Russell Boyd, Edward G. Corley, Jeffrey S. Campbell, Nori Ikemoto, Robert D. Larsen, Richard G. Ball, Nancy Barta
Publikováno v:
Canadian Journal of Chemistry. 80:646-652
The convergent synthesis of a potent α1A-selective adrenoceptor antagonist is described. Salient features of the synthesis include the enzymatic resolution of a racemic dihydropyrimidinone and the use of a palladium coupling reaction in the synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::036b92db4e774125c2e875505052b452
https://doi.org/10.1139/v02-079
https://doi.org/10.1139/v02-079