Výsledky vyhledávání - "Michel, Burcklen"

Akademický článek

An exposure‐response analysis of ponesimod clinical efficacy in a randomized phase III study in patients with relapsing multiple sclerosis

Autor: Belén Valenzuela, Per Olsson Gisleskog, Italo Poggesi, Tatiana Sidorenko, Michel Burcklen, Hilke Kracker, Juan Jose Pérez‐Ruixo

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 10, Pp 1294-1304 (2022)

Abstract The efficacy of ponesimod and teriflunomide for the treatment of relapsing multiple sclerosis (MS) was compared in a randomized phase III trial. This study explores the exposure‐response (E‐R) relationships of efficacy end points (annual

Externí odkaz: https://doaj.org/article/531afc9bc7ca4e63b7b43fe2aa37c10f

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Long-term Treatment With Ponesimod in Relapsing-Remitting Multiple Sclerosis

Autor: Mark S, Freedman, Carlo, Pozzilli, Eva Kubala, Havrdova, Alexandre, Lemle, Michel, Burcklen, Anna, Larbalestier, Brian, Hennessy, Tatiana, Sidorenko, Andrea, Vaclavkova, Tomas, Olsson

Publikováno v: Neurology. 99:e762-e774

ObjectiveTo evaluate the dose-response relationship of 10, 20, and 40 mg ponesimod and long-term efficacy and safety of ponesimod 20 mg using an analysis of combined data from the phase 2 Core and Extension studies in patients with relapsing-remittin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4ac00dbb03653b5ac76c9cf9253087
https://doi.org/10.1212/wnl.0000000000200606

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An Exposure-Response Analysis of the Clinical Efficacy of Ponesimod in a Randomized Phase II Study in Patients with Multiple Sclerosis

Autor: Michel Burcklen, Tatiana Scherz, Belén Valenzuela, Per Olsson Gisleskog, Italo Poggesi, Juan Jose Perez-Ruixo

Publikováno v: Clinical Pharmacokinetics. 60:1227-1237

Ponesimod is a sphingosphine-1-phosphate receptor modulator being developed for the treatment of multiple sclerosis. The effects of disease-modifying treatments on magnetic resonance imaging (MRI) lesions in relapsing multiple sclerosis accurately pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b4dd77655ac059508f90ec0ef604a2
https://doi.org/10.1007/s40262-021-01020-2

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Vivacity MG Phase 3 Study: Clinical Trial of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

Autor: Sindhu Ramchandren, Panna Sanga, Michel Burcklen, Hong Sun

Publikováno v: Neurology. 99:S41.2-S41

ObjectiveWe describe Vivacity-MG3. our pivotal Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Nipocalimab Administered to Adults With gMG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::706a4ce0b9d0fa60d70ad03417a5382f
https://doi.org/10.1212/01.wnl.0000903328.46907.49

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Oral ponesimod in patients with chronic plaque psoriasis: a randomised, double-blind, placebo-controlled phase 2 trial

Autor: Andrea Vaclavkova, Paul-Gunther Sator, Péter Holló, Daniele D'Ambrosio, Sergio Chimenti, Petr Arenberger, Mylene Stefani, Michel Burcklen

Publikováno v: The Lancet. 384:2036-2045

We assessed the efficacy, safety, and tolerability of ponesimod, an oral, selective, reversible modulator of sphingosine 1-phosphate receptor 1, in patients with moderate to severe chronic plaque psoriasis.Between Sept 22, 2010, and Oct 24, 2012, pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121d38c67e2504ec6042cfae43bebbbf
https://doi.org/10.1016/s0140-6736(14)60803-5

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The reductase activity of the Arabidopsis caleosin RESPONSIVE TO DESSICATION20 mediates gibberellin-dependent flowering time, abscisic acid sensitivity, and tolerance to oxidative stress

Autor: Elizabeth Blée, Jürgen Ehlting, Benoît Boachon, Michel Burcklen, Jean-Jacques Bessoule, Dimitri Heintz, Marina Le Guédard, Abdulsamie Hanano, Ivo Feussner, Cornelia Herrfurth

Publikováno v: Plant Physiology
Plant Physiology, American Society of Plant Biologists, 2014, 166 (1), pp.109-124. ⟨10.1104/pp.114.245316⟩
Plant Physiology, American Society of Plant Biologists, 2014, 166 (1), pp.109-124

Contrasting with the wealth of information available on the multiple roles of jasmonates in plant development and defense, knowledge about the functions and the biosynthesis of hydroxylated oxylipins remains scarce. By expressing the caleosin RESPONS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdcde5916a3d27be09773c4dd722f95e
https://pubmed.ncbi.nlm.nih.gov/25056921

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Plant seed peroxygenase is an original heme-oxygenase with an EF-hand calcium binding motif

Autor: Michel Burcklen, Abdulsamie Hanano, Anabella Ivancich, Mathilde Louwagie, Martine Flenet, Elizabeth Blée, Jérôme Garin

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2008, 281, pp.33140-33151

A growing body of evidence indicates that phytooxylipins play important roles in plant defense responses. However, many enzymes involved in the biosynthesis of these metabolites are still elusive. We have purified one of these enzymes, the peroxygena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55a6d4962e302bd66de866750229334
https://hal.archives-ouvertes.fr/hal-00341938

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