Cellular adaptation of Clostridioides difficile to high salinity encompasses a compatible solute-responsive change in cell morphology

Autor: Michel, Annika Marisa, Borrero de Acuña, José Manuel, Molinari, Gabriella, Unal, Can Murat, Will, Sabine, Derksen, Elisabeth

Infections by the pathogenic gut bacterium Clostridioides difficile cause severe diarrhoeas up to a toxic megacolon and are currently among the major causes of lethal bacterial infections. Successful bacte rial propagation in the gut is strongly asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3272::e53b5490d20e9657be76fb906eb7e288

Influence of L-lactate and low glucose concentrations on the metabolism and the toxin formation of Clostridioides difficile

Autor: Hofmann, Julia Danielle, Biedendieck, Rebekka, Michel, Annika-Marisa, Schomburg, Dietmar, Jahn, Dieter, Neumann-Schaal, Meina

Publikováno v: PLOS ONE, 16(1):e0244988
PLoS ONE, Vol 16, Iss 1, p e0244988 (2021)
PLoS ONE

The virulence of Clostridioides difficile (formerly Clostridium difficile) is mainly caused by its two toxins A and B. Their formation is significantly regulated by metabolic processes. Here we investigated the influence of various sugars (glucose, f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::86b7b3388973f91b3c7dac7086aa6641
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0244988#sec019

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Metabolic Reprogramming of Clostridioides difficile During the Stationary Phase With the Induction of Toxin Production

Autor: Hofmann, Julia D., Otto, Andreas, Berges, Mareike, Biedendieck, Rebekka, Michel, Annika-Marisa, Becher, Dörte, Jahn, Dieter, Neumann-Schaal, Meina

Publikováno v: Frontiers in microbiology, 9:1970. doi: 10.3389/fmicb.2018.01970--Front Microbiol--https://www.ncbi.nlm.nih.gov/pmc/journals/1526/--http://www.frontiersin.org/microbiology--http://www.bibliothek.uni-regensburg.de/ezeit/?2587354--1664-302X--1664-302X
Frontiers in microbiology, 9:1970
Frontiers in Microbiology

The obligate anaerobe, spore forming bacterium Clostridioides difficile (formerly Clostridium difficile) causes nosocomial and community acquired diarrhea often associated with antibiotic therapy. Major virulence factors of the bacterium are the two

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