Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Micheal S. Ward"'
Autor:
Danielle J. Borg, Pouya Faridi, Kai Lin Giam, Peta Reeves, Amelia K. Fotheringham, Domenica A. McCarthy, Sherman Leung, Micheal S. Ward, Brooke E. Harcourt, Rochelle Ayala, Jean L. Scheijen, David Briskey, Nadine L. Dudek, Casper G. Schalkwijk, Raymond Steptoe, Anthony W. Purcell, Josephine M. Forbes
Publikováno v:
Metabolites, Vol 11, Iss 7, p 426 (2021)
Mechanisms by which advanced glycation end products (AGEs) contribute to type 1 diabetes (T1D) pathogenesis are poorly understood. Since life-long pharmacotherapy with alagebrium chloride (ALT) slows progression to experimental T1D, we hypothesized t
Externí odkaz:
https://doaj.org/article/aa01d89ace73484cadb792438502955d
Autor:
Sachin S Thakur, Micheal S Ward, Amirali Popat, Nicole B Flemming, Marie-Odile Parat, Nigel L Barnett, Harendra S Parekh
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178305 (2017)
Herein we showcase the potential of ultrasound-responsive nanobubbles in enhancing macromolecular permeation through layers of the retina, ultimately leading to significant and direct intracellular delivery; this being effectively demonstrated across
Externí odkaz:
https://doaj.org/article/8c348a97c3884acaacf223e5babfeb97
Autor:
Anthony W. Purcell, Casper G. Schalkwijk, Rochelle Ayala, David Briskey, Jean L.J.M. Scheijen, Josephine M. Forbes, Raymond J. Steptoe, Kai Lin Giam, Sherman Leung, Domenica A. McCarthy, Brooke E. Harcourt, Micheal S. Ward, Peta L. S. Reeves, Amelia K. Fotheringham, Pouya Faridi, Danielle J. Borg, Nadine L. Dudek
Publikováno v:
Metabolites
Volume 11
Issue 7
Metabolites, Vol 11, Iss 426, p 426 (2021)
Metabolites, 11(7):426. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 11
Issue 7
Metabolites, Vol 11, Iss 426, p 426 (2021)
Metabolites, 11(7):426. Multidisciplinary Digital Publishing Institute (MDPI)
Mechanisms by which advanced glycation end products (AGEs) contribute to type 1 diabetes (T1D) pathogenesis are poorly understood. Since life-long pharmacotherapy with alagebrium chloride (ALT) slows progression to experimental T1D, we hypothesized t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a32c3a88149b4349c0a51a2c8471c0
http://europepmc.org/articles/PMC8305727
http://europepmc.org/articles/PMC8305727
Autor:
Samantha J. Stehbens, Leisl M. Packer, Robert J. Ju, Jennifer H. Gunter, Michael Gartside, Pamela M. Pollock, Micheal S. Ward, Vanessa F. Bonazzi, Sara A. Byron
Publikováno v:
Molecular Oncology, Vol 13, Iss 4, Pp 738-756 (2019)
Molecular Oncology
Molecular Oncology
Endometrial cancer is the most commonly diagnosed gynaecological malignancy. Unfortunately, 15-20% of women demonstrate persistent or recurrent tumours that are refractory to current chemotherapies. We previously identified activating mutations in fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fb603125a0918fbfd3853fe27a5982
https://doaj.org/article/234c76f07ab648e28386f7e7423d6c89
https://doaj.org/article/234c76f07ab648e28386f7e7423d6c89
Autor:
Ralph Buttyan, Brett G. Hollier, Jennifer H. Gunter, Martin C. Sadowski, Chenwei Wang, Abhishek S. Kashyap, Martin E. Gleave, Colleen C. Nelson, Elizabeth D. Williams, Nataly Stylianou, Anja Rockstroh, Atefeh Taherian Fard, Micheal S. Ward, Melanie Lehman, Lidija Jovanovic, Thomas F. Westbrook, Ladan Fazli
Publikováno v:
Oncogene. 38:913-934
The propensity of cancer cells to transition between epithelial and mesenchymal phenotypic states via the epithelial–mesenchymal transition (EMT) program can regulate metastatic processes, cancer progression, and treatment resistance. Transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4792c4f0830fb7f8d3cc0a9b7a8d8b1d
https://doi.org/10.1038/s41388-018-0488-5
https://doi.org/10.1038/s41388-018-0488-5
Publikováno v:
Neurochemistry International. 92:1-12
Nitroxides have been exploited as profluorescent probes for the detection of oxidative stress. In addition, they deliver potent antioxidant action and attenuate reactive oxygen species (ROS) in various models of oxidative stress, with these results a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de6a54e0ce3dad1c3b693be1056d035
https://doi.org/10.1016/j.neuint.2015.11.003
https://doi.org/10.1016/j.neuint.2015.11.003
Autor:
Micheal S. Ward, Carmel M. McVicar, M Kolibabka, Andreas Schlotterer, Hans-Peter Hammes, Angelika Bierhaus, Mei Chen, Jasenka Guduric-Fuchs, Liza Colhoun, Thomas Fleming, Alan W. Stitt
Publikováno v:
Diabetologia
McVicar, C M, Ward, M, Colhoun, L M, Guduric-Fuchs, J, Bierhaus, A, Fleming, T, Schlotterer, A, Kolibabka, M, Hammes, H-P, Chen, M & Stitt, A W 2015, ' Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice ', Diabetologia, vol. 58, no. 5, pp. 1129-37 . https://doi.org/10.1007/s00125-015-3523-x
McVicar, C M, Ward, M, Colhoun, L M, Guduric-Fuchs, J, Bierhaus, A, Fleming, T, Schlotterer, A, Kolibabka, M, Hammes, H-P, Chen, M & Stitt, A W 2015, ' Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice ', Diabetologia, vol. 58, no. 5, pp. 1129-37 . https://doi.org/10.1007/s00125-015-3523-x
Aims/hypothesis The receptor for AGEs (RAGE) is linked to proinflammatory pathology in a range of tissues. The objective of this study was to assess the potential modulatory role of RAGE in diabetic retinopathy. Methods Diabetes was induced in wild-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62a63d64c5f5e6743eed6fb7dbcca0c
http://europepmc.org/articles/PMC4392170
http://europepmc.org/articles/PMC4392170
Autor:
Nicole B. Flemming, Linda A. Gallo, Mark P. Hodson, David Briskey, Peter H. Tang, Josephine M. Forbes, Michael P. Murphy, Hannah Shaw, Manuel R. Plan, Danielle J. Borg, Aowen Zhuang, Benjamin Harvie, Amelia K. Fotheringham, Domenica A. McCarthy, Micheal S. Ward, Llion A. Roberts
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Mitochondrial dysfunction is a pathological mediator of diabetic kidney disease (DKD). Our objective was to test the mitochondrially targeted agent, MitoQ, alone and in combination with first line therapy for DKD. Intervention therapies (i) vehicle (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fde392f64815a626723ff77f853e19
https://doi.org/10.1038/s41598-017-15589-x
https://doi.org/10.1038/s41598-017-15589-x
Publikováno v:
Journal of Endocrinology. 224:139-147
Clinical cases of glucocorticoid (GC) excess are characterized by increased fat mass and obesity through the accumulation of white adipocytes. The effects of GCs on growth and function of brown adipose tissue are unknown and may contribute to the neg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa372d71de9c9d6add40fc47f7f751f2
https://doi.org/10.1530/joe-14-0538
https://doi.org/10.1530/joe-14-0538
Autor:
Linda A. Gallo, Felicia Y. T. Yap, Shaun A. Summers, Josephine M. Forbes, Karly C. Sourris, Domenica A. McCarthy, Micheal S. Ward, Arthur R Kitching, David J. Nikolic-Paterson, Joshua Y. Kausman, Adeline L.Y. Tan, Amelia K. Fotheringham, Allison R. Pettit, Brooke E. Harcourt, Danielle J. Borg, Gregory H Tesch
Publikováno v:
Diabetologia. 57:1977-1985
The AGEs and the receptor for AGEs (RAGE) are known contributors to diabetic complications. RAGE also has a physiological role in innate and adaptive immunity and is expressed on immune cells. The aim of this study was to determine whether deletion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc12c71b17ef8f5eda43677f20a99fe6
https://doi.org/10.1007/s00125-014-3291-z
https://doi.org/10.1007/s00125-014-3291-z