Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina.

Autor: Sachin S Thakur, Micheal S Ward, Amirali Popat, Nicole B Flemming, Marie-Odile Parat, Nigel L Barnett, Harendra S Parekh

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0178305 (2017)

Herein we showcase the potential of ultrasound-responsive nanobubbles in enhancing macromolecular permeation through layers of the retina, ultimately leading to significant and direct intracellular delivery; this being effectively demonstrated across

Externí odkaz: https://doaj.org/article/8c348a97c3884acaacf223e5babfeb97

Bcl‐2 inhibitors enhance FGFR inhibitor‐induced mitochondrial‐dependent cell death in FGFR2‐mutant endometrial cancer

Autor: Samantha J. Stehbens, Leisl M. Packer, Robert J. Ju, Jennifer H. Gunter, Michael Gartside, Pamela M. Pollock, Micheal S. Ward, Vanessa F. Bonazzi, Sara A. Byron

Publikováno v: Molecular Oncology, Vol 13, Iss 4, Pp 738-756 (2019)
Molecular Oncology

Endometrial cancer is the most commonly diagnosed gynaecological malignancy. Unfortunately, 15-20% of women demonstrate persistent or recurrent tumours that are refractory to current chemotherapies. We previously identified activating mutations in fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fb603125a0918fbfd3853fe27a5982
https://doaj.org/article/234c76f07ab648e28386f7e7423d6c89

A molecular portrait of epithelial–mesenchymal plasticity in prostate cancer associated with clinical outcome

Autor: Ralph Buttyan, Brett G. Hollier, Jennifer H. Gunter, Martin C. Sadowski, Chenwei Wang, Abhishek S. Kashyap, Martin E. Gleave, Colleen C. Nelson, Elizabeth D. Williams, Nataly Stylianou, Anja Rockstroh, Atefeh Taherian Fard, Micheal S. Ward, Melanie Lehman, Lidija Jovanovic, Thomas F. Westbrook, Ladan Fazli

Publikováno v: Oncogene. 38:913-934

The propensity of cancer cells to transition between epithelial and mesenchymal phenotypic states via the epithelial–mesenchymal transition (EMT) program can regulate metastatic processes, cancer progression, and treatment resistance. Transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4792c4f0830fb7f8d3cc0a9b7a8d8b1d
https://doi.org/10.1038/s41388-018-0488-5

Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice

Autor: Micheal S. Ward, Carmel M. McVicar, M Kolibabka, Andreas Schlotterer, Hans-Peter Hammes, Angelika Bierhaus, Mei Chen, Jasenka Guduric-Fuchs, Liza Colhoun, Thomas Fleming, Alan W. Stitt

Publikováno v: Diabetologia
McVicar, C M, Ward, M, Colhoun, L M, Guduric-Fuchs, J, Bierhaus, A, Fleming, T, Schlotterer, A, Kolibabka, M, Hammes, H-P, Chen, M & Stitt, A W 2015, ' Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice ', Diabetologia, vol. 58, no. 5, pp. 1129-37 . https://doi.org/10.1007/s00125-015-3523-x

Aims/hypothesis The receptor for AGEs (RAGE) is linked to proinflammatory pathology in a range of tissues. The objective of this study was to assess the potential modulatory role of RAGE in diabetic retinopathy. Methods Diabetes was induced in wild-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62a63d64c5f5e6743eed6fb7dbcca0c
http://europepmc.org/articles/PMC4392170

Effects of glucocorticoids on human brown adipocytes

Autor: Hadiya Agada, Neil Wetzig, Micheal S. Ward, Christina Jang, Ken K. Y. Ho, Johanna L. Barclay

Publikováno v: Journal of Endocrinology. 224:139-147

Clinical cases of glucocorticoid (GC) excess are characterized by increased fat mass and obesity through the accumulation of white adipocytes. The effects of GCs on growth and function of brown adipose tissue are unknown and may contribute to the neg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa372d71de9c9d6add40fc47f7f751f2
https://doi.org/10.1530/joe-14-0538