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Gut microbiota-driven brain Aβ amyloidosis in mice requires microglia

Autor: Dodiya, Hemraj B, Lutz, Holly L, Weigle, Ian Q, Patel, Priyam, Michalkiewicz, Julia, Roman-Santiago, Carlos J, Zhang, Can Martin, Liang, Yingxia, Srinath, Abhinav, Zhang, Xulun, Xia, Jessica, Olszewski, Monica, Zhang, Xiaoqiong, Schipma, Matthew John, Chang, Eugene B, Tanzi, Rudolph E, Gilbert, Jack A, Sisodia, Sangram S

Publikováno v: The Journal of experimental medicine, vol 219, iss 1

We previously demonstrated that lifelong antibiotic (ABX) perturbations of the gut microbiome in male APPPS1-21 mice lead to reductions in amyloid β (Aβ) plaque pathology and altered phenotypes of plaque-associated microglia. Here, we show that a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::31423951901e612ab08bb421dffbb048
https://escholarship.org/uc/item/8jd8825x

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Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.

Autor: Bosch ME; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, USA., Dodiya HB; Department of Neurobiology, University of Chicago, Chicago, USA., Michalkiewicz J; Department of Neurobiology, University of Chicago, Chicago, USA., Lee C; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, USA., Shaik SM; Department of Neurobiology, University of Chicago, Chicago, USA., Weigle IQ; Department of Neurobiology, University of Chicago, Chicago, USA., Zhang C; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Osborn J; Department of Neurobiology, University of Chicago, Chicago, USA., Nambiar A; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, USA., Patel P; Center for Genetic Medicine, Northwestern University, Chicago, USA., Parhizkar S; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, USA., Zhang X; Department of Neurobiology, University of Chicago, Chicago, USA., Laury ML; Genome Technology Access Center, Washington University in St. Louis, St. Louis, USA., Mondal P; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Gomm A; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Schipma MJ; Center for Genetic Medicine, Northwestern University, Chicago, USA., Mallah D; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Butovsky O; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Chang EB; Department Medicine, Section of Gastroenterology, Hepatology, and Nutrition, The University of Chicago, Chicago, USA., Tanzi RE; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Gilbert JA; Department of Pediatrics and Scripps Institution of Oceanography, UCSD, San Diego, USA., Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, USA. holtzman@wustl.edu., Sisodia SS; Department of Neurobiology, University of Chicago, Chicago, USA. ssisodia@bsd.uchicago.edu.

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2024 Oct 10; Vol. 19 (1), pp. 70. Date of Electronic Publication: 2024 Oct 10.

Histone Modifications in Mouse Pronuclei and Consequences for Embryo Development.

Autor: Borsuk E; Department of Embryology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Warsaw, Poland. e.borsuk@uw.edu.pl., Michalkiewicz J; Department of Embryology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Warsaw, Poland., Kubiak JZ; Dynamics and Mechanics of Epithelia Group, Institute of Genetics and Development of Rennes, UMR 6290, CNRS, Faculty of Medicine, University of Rennes, Rennes, France.; Laboratory of Molecular Oncology and Innovative Therapies, Department of Oncology, Military Institute of Medicine, Warsaw, Poland., Kloc M; The Houston Methodist Research Institute, Houston, TX, USA.; Department of Surgery, The Houston Methodist Hospital, Houston, TX, USA.; Department of Genetics, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.

Publikováno v: Results and problems in cell differentiation [Results Probl Cell Differ] 2022; Vol. 70, pp. 397-415.