Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Michalis, Barkoulas"'
Autor:
Kenneth Liu, Manish Grover, Franziska Trusch, Christina Vagena-Pantoula, Domenica Ippolito, Michalis Barkoulas
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114906- (2024)
Summary: Innate immune responses can be triggered upon detection of pathogen- or damage-associated molecular patterns by host receptors that are often present on the surface of immune cells. While invertebrates like Caenorhabditis elegans lack profes
Externí odkaz:
https://doaj.org/article/4b3046fc8582470c9ea4a32d1aac1bd1
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002543 (2024)
Protein quality control pathways play important roles in resistance against pathogen infection. For example, the conserved transcription factor SKN-1/NRF up-regulates proteostasis capacity after blockade of the proteasome and also promotes resistance
Externí odkaz:
https://doaj.org/article/fec3952dc6294cdba47bf1f925fd0cd5
Autor:
Spencer S Gang, Manish Grover, Kirthi C Reddy, Deevya Raman, Ya-Ting Chang, Damian C Ekiert, Michalis Barkoulas, Emily R Troemel
Publikováno v:
PLoS Genetics, Vol 18, Iss 10, p e1010314 (2022)
Regulation of immunity throughout an organism is critical for host defense. Previous studies in the nematode Caenorhabditis elegans have described an "ON/OFF" immune switch comprised of the antagonistic paralogs PALS-25 and PALS-22, which regulate re
Externí odkaz:
https://doaj.org/article/538bfe5c9edc48ddbfd2c5f488e5aca2
Autor:
Sneha L. Koneru, Fu Xiang Quah, Ritobrata Ghose, Mark Hintze, Nicola Gritti, Jeroen Sebastiaan van Zon, Michalis Barkoulas
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Developmental patterning in Caenorhabditis elegans is known to proceed in a highly stereotypical manner, which raises the question of how developmental robustness is achieved despite the inevitable stochastic noise. We focus here on a popula
Externí odkaz:
https://doaj.org/article/b3d14064a7df42bfb896368139637f03
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
How the genetic background modifies the expression of mutations is a key question that is addressed in this study in the context of seam cell development in Caenorhabditis elegans isolates. One amino acid deletion in a conserved heat shock protein is
Externí odkaz:
https://doaj.org/article/4e46d30d12474282beb7d61ec7f184b5
Autor:
Manish Grover, Michael K. Fasseas, Clara Essmann, Kenneth Liu, Christian Braendle, Marie-Anne Félix, Sally L. Glockling, Michalis Barkoulas
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Oomycetes are a group of eukaryotic organisms that includes many important pathogens of animals and plants. Within this group, the Haptoglossa genus is characterised by the presence of specialised gun cells carrying a harpoon-like infection apparatus
Externí odkaz:
https://doaj.org/article/0deb4b782fb64928b09e3d7630711c7f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Individual cells and organisms experience perturbations from internal and external sources, yet manage to buffer these to produce consistent phenotypes, a property known as robustness. While phenotypic robustness has often been examined in unicellula
Externí odkaz:
https://doaj.org/article/d02c0890d9264239bcde16feeecaa6e1
Autor:
Manish Grover, Michalis Barkoulas
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009316 (2021)
Externí odkaz:
https://doaj.org/article/bc3ad8a64c6642b2a14eb367f5035403
Autor:
Michael K. Fasseas, Manish Grover, Florence Drury, Clara L. Essmann, Eva Kaulich, William R. Schafer, Michalis Barkoulas
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108604- (2021)
Summary: Understanding how animals detect and respond to pathogen threats is central to dissecting mechanisms of host immunity. The oomycetes represent a diverse eukaryotic group infecting various hosts from nematodes to humans. We have previously sh
Externí odkaz:
https://doaj.org/article/26ea6fa6476e4f6fae738f84dd54b2fe
Autor:
Rebecca C Adikes, Abraham Q Kohrman, Michael A Q Martinez, Nicholas J Palmisano, Jayson J Smith, Taylor N Medwig-Kinney, Mingwei Min, Maria D Sallee, Ononnah B Ahmed, Nuri Kim, Simeiyun Liu, Robert D Morabito, Nicholas Weeks, Qinyun Zhao, Wan Zhang, Jessica L Feldman, Michalis Barkoulas, Ariel M Pani, Sabrina L Spencer, Benjamin L Martin, David Q Matus
Publikováno v:
eLife, Vol 9 (2020)
Cell proliferation and quiescence are intimately coordinated during metazoan development. Here, we adapt a cyclin-dependent kinase (CDK) sensor to uncouple these key events of the cell cycle in Caenorhabditis elegans and zebrafish through live-cell i
Externí odkaz:
https://doaj.org/article/ef13a2875ea8461db4c27f46e2101a88