Výsledky vyhledávání - "Michalina Janiszewska"

Akademický článek

Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma

Autor: Kacper A. Walentynowicz, Dalit Engelhardt, Simona Cristea, Shreya Yadav, Ugoma Onubogu, Roberto Salatino, Melanie Maerken, Cristina Vincentelli, Aashna Jhaveri, Jacob Geisberg, Thomas O. McDonald, Franziska Michor, Michalina Janiszewska

Publikováno v: Cell Reports, Vol 42, Iss 3, Pp 112235- (2023)

Summary: Glioblastoma (GBM) is the most aggressive brain tumor, with a median survival of ∼15 months. Targeted approaches have not been successful in this tumor type due to the large extent of intratumor heterogeneity. Mosaic amplification of oncog

Externí odkaz: https://doaj.org/article/60308efb3c604892b7520a2072a1e78d

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Akademický článek

The impact of tumor epithelial and microenvironmental heterogeneity on treatment responses in HER2+ breast cancer

Publikováno v: JCI Insight, Vol 6, Iss 11 (2021)

Despite the availability of multiple human epidermal growth factor receptor 2–targeted (HER2-targeted) treatments, therapeutic resistance in HER2+ breast cancer remains a clinical challenge. Intratumor heterogeneity for HER2 and resistance-conferri

Externí odkaz: https://doaj.org/article/ced21837b6ad4073a0511b1ee2946f97

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Akademický článek

The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing

Autor: Nils Degrauwe, Tommy B. Schlumpf, Michalina Janiszewska, Patricia Martin, Alexandra Cauderay, Paolo Provero, Nicolo Riggi, Mario-L. Suvà, Renato Paro, Ivan Stamenkovic

Publikováno v: Cell Reports, Vol 15, Iss 8, Pp 1634-1647 (2016)

Cancer stem cells (CSCs) can drive tumor growth, and their maintenance may rely on post-transcriptional regulation of gene expression, including that mediated by microRNAs (miRNAs). The let-7 miRNA family has been shown to induce differentiation by s

Externí odkaz: https://doaj.org/article/ade7b28da6e345d6b3b4ca6c55bd81c8

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Akademický článek

Let-7a is a direct EWS-FLI-1 target implicated in Ewing's sarcoma development.

Autor: Claudio De Vito, Nicolo Riggi, Mario-Luca Suvà, Michalina Janiszewska, Janine Horlbeck, Karine Baumer, Paolo Provero, Ivan Stamenkovic

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23592 (2011)

Ewing's sarcoma family tumors (ESFT) are the second most common bone malignancy in children and young adults, characterized by unique chromosomal translocations that in 85% of cases lead to expression of the EWS-FLI-1 fusion protein. EWS-FLI-1 functi

Externí odkaz: https://doaj.org/article/753efa60d63842cd8b00a5fedd1915d6

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Akademický článek

Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1.

Autor: Luisa Cironi, Paolo Provero, Nicola Riggi, Michalina Janiszewska, Domizio Suva, Mario-Luca Suva, Vincent Kindler, Ivan Stamenkovic

Publikováno v: PLoS ONE, Vol 4, Iss 11, p e7904 (2009)

BACKGROUND: A characteristic SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is detectable in almost all synovial sarcomas, a malignant soft tissue tumor widely believed to originate from as yet unidentified pluripot

Externí odkaz: https://doaj.org/article/48efa1b857504a38acffedbabdbbeefc

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