Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michala Zgarbová"'
Autor:
Eva Konkolova, Kateřina Krejčová, Luděk Eyer, Jan Hodek, Michala Zgarbová, Andrea Fořtová, Michael Jirasek, Filip Teply, Paul E. Reyes-Gutierrez, Daniel Růžek, Jan Weber, Evzen Boura
Publikováno v:
Molecules, Vol 27, Iss 6, p 1894 (2022)
Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +R
Externí odkaz:
https://doaj.org/article/2f4731e5b3e6434d9eb602e26cd5aaae
Autor:
Zulal Özdemir, Uladzimir Bildziukevich, Martina Čapková, Petra Lovecká, Lucie Rárová, David Šaman, Michala Zgarbová, Barbora Lapuníková, Jan Weber, Oxana Kazakova, Zdeněk Wimmer
Publikováno v:
Biomedicines, Vol 9, Iss 8, p 951 (2021)
(1) Background: To compare the effect of selected triterpenoids with their structurally resembling derivatives, designing of the molecular ribbons was targeted to develop compounds with selectivity in their pharmacological effects. (2) Methods: In th
Externí odkaz:
https://doaj.org/article/2a5e73deb0554ae48aca238727c9dc18
Autor:
Martin Dračínský, Michala Zgarbová, Filip Kalčic, Helena Mertlíková-Kaiserová, Karel Chalupský, Alexandra Dvořáková, Jan Hodek, Timotej Strmeň, Jaroslav Šebestík, Jan Weber, Zlatko Janeba, Ondřej Baszczyňski
Publikováno v:
Journal of medicinal chemistry. 64(22)
This study describes the discovery of novel prodrugs bearing tyrosine derivatives instead of the phenol moiety present in FDA-approved tenofovir alafenamide fumarate (TAF). The synthesis was optimized to afford diastereomeric mixtures of novel prodru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9536c70309f0c46f768a0ddbdd2433
https://pubmed.ncbi.nlm.nih.gov/34783565
https://pubmed.ncbi.nlm.nih.gov/34783565
Autor:
Jan Weber, Oxana B. Kazakova, David Šaman, Zülal Özdemir, Petra Lovecká, Michala Zgarbová, Martina Čapková, Barbora Lapuníková, Lucie Rárová, Uladzimir Bildziukevich, Zdeněk Wimmer
Publikováno v:
Biomedicines
Volume 9
Issue 8
Biomedicines, Vol 9, Iss 951, p 951 (2021)
Volume 9
Issue 8
Biomedicines, Vol 9, Iss 951, p 951 (2021)
(1) Background: To compare the effect of selected triterpenoids with their structurally resembling derivatives, designing of the molecular ribbons was targeted to develop compounds with selectivity in their pharmacological effects. (2) Methods: In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca2d4b023be34722d304e28f33a43de
https://pubmed.ncbi.nlm.nih.gov/34440155
https://pubmed.ncbi.nlm.nih.gov/34440155
Autor:
Mikolaj Zmudzinski, Wioletta Rut, Kamila Olech, Jarosław Granda, Mirosław Giurg, Małgorzata Burda-Grabowska, Rafał Kaleta, Michala Zgarbova, Renata Kasprzyk, Linlin Zhang, Xinyuanyuan Sun, Zongyang Lv, Digant Nayak, Malgorzata Kesik-Brodacka, Shaun K. Olsen, Jan Weber, Rolf Hilgenfeld, Jacek Jemielity, Marcin Drag
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against COVID-19. SARS-CoV-2 main protease (Mpro, 3CLpro) and papain-like protease (PLpro) are responsible for viral polyprotein cleavage—a process crucial for
Externí odkaz:
https://doaj.org/article/01362b97d3a24b76b811f51a8665c29d