Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding

Autor: Adriana Ibarra Urizar, Michala Prause, Lars Roed Ingerslev, Matthew Wortham, Yinghui Sui, Maike Sander, Kristine Williams, Romain Barrès, Martin R. Larsen, Gitte Lund Christensen, Nils Billestrup

Publikováno v: Cell Death and Disease, Vol 14, Iss 7, Pp 1-16 (2023)

Summary Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by decreased expression of several key beta cell genes. The pro-inflammatory factor BMP-2 is upregulated in islet

Externí odkaz: https://doaj.org/article/ff71f86b08274f6ea980a103f69cf1c4

JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis.

Autor: Michala Prause, Dan Ploug Christensen, Nils Billestrup, Thomas Mandrup-Poulsen

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e87067 (2014)

Pancreatic β-cell dysfunction is central to type 2 diabetes pathogenesis. Prolonged elevated levels of circulating free-fatty acids and hyperglycemia, also termed glucolipotoxicity, mediate β-cell dysfunction and apoptosis associated with increased

Externí odkaz: https://doaj.org/article/93323afdcc3e4a37b78f49c88ad3802d

SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients

Autor: Kira Meyerovich, Caroline Frørup, Simranjeet Kaur, Alessandra K Cardozo, Lotte B. Nielsen, Joachim Størling, Michala Prause, Henrik B. Mortensen, Flemming Pociot, Tina Fløyel

Publikováno v: Diabetes
Diabetes (New York, N.Y.), 70 (2

The single nucleotide polymorphism rs7804356 located in the Src kinase-associated phosphoprotein 2 (SKAP2) gene is associated with type 1 diabetes (T1D), suggesting SKAP2 as a causal candidate gene. The objective of the study was to investigate if SK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6df5a8ff92b2bedf342d204cf3a140
https://doi.org/10.2337/db20-0092

Targeted Delivery of Butyrate Improves Glucose Homeostasis, Reduces Hepatic Lipid Accumulation and Inflammation in db/db Mice

Autor: Signe Schultz Pedersen, Michala Prause, Christina Sørensen, Joachim Størling, Thomas Moritz, Eliana Mariño, Nils Billestrup

Publikováno v: Pedersen, S S, Prause, M, Sørensen, C, Størling, J, Moritz, T, Mariño, E & Billestrup, N 2023, ' Targeted Delivery of Butyrate Improves Glucose Homeostasis, Reduces Hepatic Lipid Accumulation and Inflammation in db/db Mice ', International Journal of Molecular Sciences, vol. 24, no. 5, 4533 . https://doi.org/10.3390/ijms24054533
International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4533

Butyrate produced by the gut microbiota has beneficial effects on metabolism and inflammation. Butyrate-producing bacteria are supported by diets with a high fiber content, such as high-amylose maize starch (HAMS). We investigated the effects of HAMS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e14219f13f28b5a21f9e808b52c67c
https://doi.org/10.3390/ijms24054533

The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β

Autor: Sophie Emilie Bresson, Kristian Klindt, Thomas Mandrup-Poulsen, Phillip Alexander Keller Andersen, Marie-Pierre Bousquet-Dubouch, Celina Pihl, Tenna Holgersen Bryde, Tina Dahlby, Dusan Zivkovic, Muhammad Saad Khilji, Michala Prause, Michal Marzec, Danielle Verstappen, Björn Tyrberg

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2020, 15 (2), pp.e0222432. ⟨10.1371/journal.pone.0222432⟩
Khilji, M S, Verstappen, D, Dahlby, T, Prause, M C B, Pihl, C, Bresson, S E, Bryde, T H, Andersen, P A K, Klindt, K, Zivkovic, D, Bousquet-Dubouch, M P, Tyrberg, B, Mandrup-Poulsen, T & Marzec, M T 2020, ' The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β ', PLoS ONE, vol. 15, no. 2, e0222432 . https://doi.org/10.1371/journal.pone.0222432
PLoS ONE, Vol 15, Iss 2, p e0222432 (2020)

International audience; A central and still open question regarding the pathogenesis of autoimmune diseases, such as type 1 diabetes, concerns the processes that underlie the generation of MHC-presented autoantigenic epitopes that become targets of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863383497e40a80987a92afde265bf34
https://hal-cnrs.archives-ouvertes.fr/hal-03018741/file/pone.0222432.pdf