Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Michal Vieth"'
Autor:
Kristina Kesely, Panae Noomuna, Michal Vieth, Philip Hipskind, Kasturi Haldar, Antonella Pantaleo, Francesco Turrini, Philip S Low
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242372 (2020)
Although current malaria therapies inhibit pathways encoded in the parasite's genome, we have looked for anti-malaria drugs that can target an erythrocyte component because development of drug resistance might be suppressed if the parasite cannot mut
Externí odkaz:
https://doaj.org/article/7bd3e87464514f60b6171ec47a8b2dec
Publikováno v:
Open Biology, Vol 9, Iss 4 (2019)
The RIO kinases (RIOKs) are a universal family of atypical kinases that are essential for assembly of the pre-40S ribosome complex. Here, we present the crystal structure of human RIO kinase 2 (RIOK2) bound to a specific inhibitor. This first crystal
Externí odkaz:
https://doaj.org/article/853e6c60c8bd4d2282b4322d85e51be7
Autor:
Qi Chen, Michal Vieth, David E Timm, Christine Humblet, Dina Schneidman-Duhovny, Ilan E Chemmama, Andrej Sali, Wei Zeng, Jirong Lu, Ling Liu
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175758 (2017)
Dynamics of three MET antibody constructs (IgG1, IgG2, and IgG4) and the IgG4-MET antigen complex was investigated by creating their atomic models with an integrative experimental and computational approach. In particular, we used two-dimensional (2D
Externí odkaz:
https://doaj.org/article/20ed679d31d2479d8afc55306b1b8479
Autor:
Anuradha Kumar, Allen Casey, Joshua Odingo, Edward A Kesicki, Garth Abrahams, Michal Vieth, Thierry Masquelin, Valerie Mizrahi, Philip A Hipskind, David R Sherman, Tanya Parish
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e72786 (2013)
The enzyme pantothenate synthetase, PanC, is an attractive drug target in Mycobacterium tuberculosis. It is essential for the in vitro growth of M. tuberculosis and for survival of the bacteria in the mouse model of infection. PanC is absent from mam
Externí odkaz:
https://doaj.org/article/1b6e646920674bf09c8a80ca0c02fb6f
Autor:
Kathryn M. Ferguson, Ruslan D. Novosiadly, Yang Shen, Amelie Forest, Jason M. Walker, Michelle D. Iacolina, Michael Topper, Michal Vieth, Scott W. Eastman, Jaafar N. Haidar, Atrish Bagchi
Supplementary Table S1 - Therapeutic antibody induced EGFR ECR mutations; Supplementary Table S2 - Mean SPR KD values for binding of wild type (WT) and cetuximab resistance variants of sEGFR to immobilized Fab fragments from cetuximab (FabC225) and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d92447c8e255cf0b039b66a1add238
https://doi.org/10.1158/1535-7163.22510134
https://doi.org/10.1158/1535-7163.22510134
Autor:
Ben Gold, Jun Zhang, Landys Lopez Quezada, Julia Roberts, Yan Ling, Madeleine Wood, Wasima Shinwari, Laurent Goullieux, Christine Roubert, Laurent Fraisse, Eric Bacqué, Sophie Lagrange, Bruno Filoche-Rommé, Michal Vieth, Philip A. Hipskind, Louis N. Jungheim, Jeffrey Aubé, Sarah M. Scarry, Stacey L. McDonald, Kelin Li, Andrew Perkowski, Quyen Nguyen, Véronique Dartois, Matthew Zimmerman, David B. Olsen, Katherine Young, Shilah Bonnett, Douglas Joerss, Tanya Parish, Helena I. Boshoff, Kriti Arora, Clifton E. Barry, Laura Guijarro, Sara Anca, Joaquín Rullas, Beatriz Rodríguez-Salguero, Maria S. Martínez-Martínez, Esther Porras-De Francisco, Monica Cacho, David Barros-Aguirre, Paul Smith, Steven J. Berthel, Carl Nathan, Robert H. Bates
Publikováno v:
ACS Infectious Diseases. 8:557-573
Rising antimicrobial resistance challenges our ability to combat bacterial infections. The problem is acute for tuberculosis (TB), the leading cause of death from infection before COVID-19. Here, we developed a framework for multiple pharmaceutical c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fbb240736098b21d77522307cf2134
https://doi.org/10.1021/acsinfecdis.1c00570
https://doi.org/10.1021/acsinfecdis.1c00570
Autor:
Bingfa Sun, Francis S. Willard, Dan Feng, Jorge Alsina-Fernandez, Qi Chen, Michal Vieth, Joseph D. Ho, Aaron D. Showalter, Cynthia Stutsman, Liyun Ding, Todd M. Suter, James D. Dunbar, John W. Carpenter, Faiz Ahmad Mohammed, Eitaro Aihara, Robert A. Brown, Ana B. Bueno, Paul J. Emmerson, Julie S. Moyers, Tong Sun Kobilka, Matthew P. Coghlan, Brian K. Kobilka, Kyle W. Sloop
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(13)
Significance Tirzepatide is a dual agonist of the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R), which are incretin receptors that regulate carbohydrate metabolism. This investigational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea64932e0e7ad1a4e2bcef69f757e2ca
https://pubmed.ncbi.nlm.nih.gov/35333651
https://pubmed.ncbi.nlm.nih.gov/35333651
Autor:
Betty Chau, Joseph D. Ho, Francisco J Agejas, Francis S. Willard, Ana B. Bueno, Tong Sun Kobilka, Brian K. Kobilka, Isabel Rojo, James Ficorilli, Bingfa Sun, Aaron D. Showalter, Qi Chen, Cynthia Stutsman, Dan Feng, Kyle W. Sloop, Michal Vieth, Alma Jiménez, David B. Wainscott, Graham R Cumming
Publikováno v:
Nature Chemical Biology. 16:1105-1110
Drugs that promote the association of protein complexes are an emerging therapeutic strategy. We report discovery of a G protein-coupled receptor (GPCR) ligand that stabilizes an active state conformation by cooperatively binding both the receptor an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a220ba28f95c8886d1e77753f8c975b0
https://doi.org/10.1038/s41589-020-0589-7
https://doi.org/10.1038/s41589-020-0589-7
Autor:
Michal Vieth, Panae Noomuna, Kristina R. Kesely, Philip Hipskind, Philip S. Low, Antonella Pantaleo, Kasturi Haldar, Francesco Michelangelo Turrini
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242372 (2020)
PLoS ONE
PLoS ONE
Although current malaria therapies inhibit pathways encoded in the parasite’s genome, we have looked for anti-malaria drugs that can target an erythrocyte component because development of drug resistance might be suppressed if the parasite cannot m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ee6e1b37281da032671a6c3be30abf
https://doaj.org/article/7bd3e87464514f60b6171ec47a8b2dec
https://doaj.org/article/7bd3e87464514f60b6171ec47a8b2dec
Autor:
Ana B, Bueno, Bingfa, Sun, Francis S, Willard, Dan, Feng, Joseph D, Ho, David B, Wainscott, Aaron D, Showalter, Michal, Vieth, Qi, Chen, Cynthia, Stutsman, Betty, Chau, James, Ficorilli, Francisco J, Agejas, Graham R, Cumming, Alma, Jiménez, Isabel, Rojo, Tong Sun, Kobilka, Brian K, Kobilka, Kyle W, Sloop
Publikováno v:
Nature chemical biology. 16(10)
Drugs that promote the association of protein complexes are an emerging therapeutic strategy. We report discovery of a G protein-coupled receptor (GPCR) ligand that stabilizes an active state conformation by cooperatively binding both the receptor an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d81110a8c0f747bb636b179a10be509
https://pubmed.ncbi.nlm.nih.gov/32690941
https://pubmed.ncbi.nlm.nih.gov/32690941