Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Michal Tomasz Marzec"'
Autor:
Carolin Hoefner, Tenna Holgersen Bryde, Celina Pihl, Sylvia Naiga Tiedemann, Sophie Emilie Bresson, Hajira Ahmed Hotiana, Muhammad Saad Khilji, Theodore Dos Santos, Michele Puglia, Paola Pisano, Mariola Majewska, Julia Durzynska, Kristian Klindt, Justyna Klusek, Marcelo J. Perone, Robert Bucki, Per Mårten Hägglund, Pontus Emanuel Gourdon, Kamil Gotfryd, Edyta Urbaniak, Malgorzata Borowiak, Michael Wierer, Patrick Edward MacDonald, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 152 (2023)
Apart from chaperoning, disulfide bond formation, and downstream processing, the molecular sequence of proinsulin folding is not completely understood. Proinsulin requires proline isomerization for correct folding. Since FK506-binding protein 2 (FKBP
Externí odkaz:
https://doaj.org/article/20ad96ddb7074192b89914e9a51cc41b
Autor:
Muhammad Saad Khilji, Danielle Verstappen, Tina Dahlby, Michala Cecilie Burstein Prause, Celina Pihl, Sophie Emilie Bresson, Tenna Holgersen Bryde, Phillip Alexander Keller Andersen, Kristian Klindt, Dusan Zivkovic, Marie-Pierre Bousquet-Dubouch, Björn Tyrberg, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0222432 (2020)
A central and still open question regarding the pathogenesis of autoimmune diseases, such as type 1 diabetes, concerns the processes that underlie the generation of MHC-presented autoantigenic epitopes that become targets of autoimmune attack. Protea
Externí odkaz:
https://doaj.org/article/d6b8ef2eb2994e95bba69f26b2ed0451
Autor:
Muhammad Saad Khilji, Erika Pinheiro-Machado, Tina Dahlby, Ritchlynn Aranha, Søren Buus, Morten Nielsen, Justyna Klusek, Pouya Faridi, Anthony Wayne Purcell, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
BackgroundHow immune-tolerance is lost to pancreatic β-cell peptides triggering autoimmune type 1 diabetes is enigmatic. We have shown that loss of the proinsulin ER chaperone glucose-regulated protein (GRP) 94 leads to mishandling of proinsulin, ER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a98ebea8a491174157ba147c3f433b2
https://doi.org/10.1101/2021.12.20.472059
https://doi.org/10.1101/2021.12.20.472059
