Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Michal Tokmina-Roszyk"'
Autor:
Hou-Fu Guo, Neus Bota-Rabassedas, Masahiko Terajima, B. Leticia Rodriguez, Don L. Gibbons, Yulong Chen, Priyam Banerjee, Chi-Lin Tsai, Xiaochao Tan, Xin Liu, Jiang Yu, Michal Tokmina-Roszyk, Roma Stawikowska, Gregg B. Fields, Mitchell D. Miller, Xiaoyan Wang, Juhoon Lee, Kevin N. Dalby, Chad J. Creighton, George N. Phillips, John A. Tainer, Mitsuo Yamauchi, Jonathan M. Kurie
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Guo et al. determine the molecular basis of collagen lysyl hydroxylase 2 (LH2) substrate specificity. They further show that LH2 also functions as a collagen glucosyltransferase to promote lung cancer progression.
Externí odkaz:
https://doaj.org/article/33c609a5058f4848b50950a0e6133563
Autor:
Eric Koesema, Animesh Roy, Nicholas G. Paciaroni, Carlos Coito, Michal Tokmina‐Roszyk, Thomas Kodadek
Publikováno v:
Angewandte Chemie (International ed. in English). 61(18)
There is considerable interest in the development of libraries of non-peptidic macrocycles as a source of ligands for difficult targets. We report here the solid-phase synthesis of a DNA-encoded library of several hundred thousand thioether-linked ma
Autor:
B. Leticia Rodriguez, Priyam Banerjee, Neus Bota-Rabassedas, Hou Fu Guo, Yulong Chen, Gregg B. Fields, Jiang Yu, Chi Lin Tsai, Jonathan M. Kurie, Chad J. Creighton, Xiaoyan Wang, George N. Phillips, Masahiko Terajima, John A. Tainer, Xiaochao Tan, Xin Liu, Mitsuo Yamauchi, Michal Tokmina-Roszyk, Don L. Gibbons, Kevin N. Dalby, Mitchell D. Miller, Roma Stawikowska, Ju-Hoon Lee
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Cancer cells are a major source of enzymes that modify collagen to create a stiff, fibrotic tumor stroma. High collagen lysyl hydroxylase 2 (LH2) expression promotes metastasis and is correlated with shorter survival in lung adenocarcinoma (LUAD) and
Publikováno v:
The Journal of biological chemistry. 293(43)
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that remodel the extracellular matrix environment and mitigate outside-in signaling. Loss of regulation of MMP activity plays a role in numerous pathological states. In pa
Autor:
Sabrina Amar, Gregg B. Fields, Patrick Cosme, Michal Tokmina-Roszyk, Andrew C. Terentis, Yury Gogotsi, Vadym Mochalin, Dorota Tokmina-Roszyk, Anna M. Knapinska
Publikováno v:
Peptide Science. 104:186-195
Nanodiamonds (NDs) have received considerable attention as potential drug delivery vehicles. NDs are small (∼5 nm diameter), can be surface modified in a controllable fashion with a variety of functional groups, and have little observed toxicity in
Publikováno v:
Analytical Biochemistry. 453:61-69
Due to their efficiency in the hydrolysis of the collagen triple-helix, Clostridial histolyticum collagenases are utilized for isolation of cells from various tissues, including isolation of the human pancreatic islets. However, the instability of Cl