Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Michal T, Krauze"'
Autor:
Dimitri G. Trembath, Eric S. Davis, Shanti Rao, Evan Bradler, Angelica F. Saada, Bentley R. Midkiff, Anna C. Snavely, Matthew G. Ewend, Frances A. Collichio, Carrie B. Lee, Georgia-Sofia Karachaliou, Fatih Ayvali, David W. Ollila, Michal T. Krauze, John M. Kirkwood, Benjamin G. Vincent, Nana Nikolaishvilli-Feinberg, Stergios J. Moschos
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
BackgroundHigh tumor-infiltrating lymphocytes (TILs) and hemorrhage are important prognostic factors in patients who have undergone craniotomy for melanoma brain metastases (MBM) before 2011 at the University of Pittsburgh Medical Center (UPMC). We h
Externí odkaz:
https://doaj.org/article/ba7880ac0a654f77a17bdb4209fa40aa
Autor:
Anastasia Ivanova, Dimitri G. Trembath, Michal T. Krauze, John M. Kirkwood, Nana Nikolaishvilli-Feinberg, Stergios J. Moschos
Publikováno v:
Melanoma Res
OBJECTIVE: PTEN and p16 frequently undergo (epi)genetic aberrations in melanoma resulting in decreased, or absent, protein levels. We investigated the prognostic significance of these tumor suppressor genes in melanoma brain metastases (MBMs). METHOD
Publikováno v:
Semin Immunopathol
Since the pivotal cooperative group trials in the 1980's-90's,, high-dose interferon (HDI) has been the standard of adjuvant therapy. Despite multiple other trials evaluating potential new therapies in melanoma, HDI remains the only FDA-approved ther
Autor:
Michal T. Krauze, Yoji Yamashita, Richard A Lecouteur, Robert Higgins, John Bringas, John W. Park, Daryl C. Drummond, Mitchel S. Berger, Dmitri B. Kirpotin, Krystof S. Bankiewicz, Richard F. Larson, John Forsayeth, Charles O. Noble, Peter J Dickinson
Publikováno v:
Neuro-Oncology. 12:928-940
Canine spontaneous intracranial tumors bear striking similarities to their human tumor counterparts and have the potential to provide a large animal model system for more realistic validation of novel therapies typically developed in small rodent mod
Autor:
Toshihiro Kumabe, Ryuta Saito, Krystof S. Bankiewicz, Michal T. Krauze, Shin Ichirou Sugiyama, Yoji Yamashita, Teiji Tominaga, Toshio Kikuchi
Publikováno v:
Journal of Neurosurgery. 109:867-873
Object The characteristics of polyethylene glycol–coated liposomal doxorubicin (PLD), the only liposomal drug now clinically available for intravenous injection, were investigated after convection-enhanced delivery (CED) into the rat brain parenchy
Autor:
Charles O. Noble, John W. Park, Michal T. Krauze, Tomohiro Kawaguchi, Yoji Yamashita, Krystof S. Bankiewicz, Daryl C. Drummond
Publikováno v:
Neuro-Oncology. 9:20-28
Despite multimodal treatment options, the response and survival rates for patients with malignant gliomas remain dismal. Clinical trials with convection-enhanced delivery (CED) have recently opened a new window in neuro-oncology to the direct deliver
Autor:
Mitchel S. Berger, John W. Park, Dmitri B. Kirpotin, Krystof S. Bankiewicz, Yoji Yamashita, Daryl C. Drummond, Michal T. Krauze, Charles O. Noble, Tomohiro Kawaguchi, Ryuta Saito
Publikováno v:
Targeted Oncology. 1:79-85
We previously reported that convection-enhanced delivery (CED) of liposomes into brain tissue and intracranial brain tumor xenografts produced robust tissue distribution that can be detected by magnetic resonance imaging. Considering image-guided CED
Autor:
Yoji Yamashita, Charles O. Noble, Dmitri B. Kirpotin, Krystof S. Bankiewicz, Michal T. Krauze, John W. Park, Daryl C. Drummond, Mitchel S. Berger, Ryuta Saito
Publikováno v:
Cancer Research. 66:2801-2806
We hypothesized that combining convection-enhanced delivery (CED) with a novel, highly stable nanoparticle/liposome containing CPT-11 (nanoliposomal CPT-11) would provide a dual drug delivery strategy for brain tumor treatment. Following CED in rat b
Autor:
Krystof S. Bankiewicz, Malgorzata Kohutnicka, Michal T. Krauze, Janet Cunningham, John Bringas, Piotr Hadaczek, Phil Pivirotto
Publikováno v:
Human Gene Therapy. 17:291-302
Adeno-associated virus type 2 (AAV2)-based vectors are promising transgene carriers for experimental gene therapy treatments of brain diseases. However, detailed evaluation of transgene distribution, trafficking, and transport within the brain is of
Autor:
Dimitri B. Kirpotin, Krystof S. Bankiewicz, John Bringas, Tracy R. McKnight, Daryl C. Drummond, Keelung Hong, Pamela R. Jackson, John W. Park, Mitchel S. Berger, Ryuta Saito, Michael F. Wendland, Charles O. Noble, Michal T. Krauze, Christoph Mamot
Publikováno v:
Experimental Neurology. 196:381-389
Drug delivery to brain tumors has long posed a major challenge. Convection-enhanced delivery (CED) has been developed as a drug delivery strategy to overcome this difficulty. Ideally, direct visualization of the tissue distribution of drugs infused b