Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Michal Slyper"'
Autor:
Ayshwarya Subramanian, Katherine A. Vernon, Yiming Zhou, Jamie L. Marshall, Maria Alimova, Carlos Arevalo, Fan Zhang, Michal Slyper, Julia Waldman, Monica S. Montesinos, Danielle Dionne, Lan T. Nguyen, Michael S. Cuoco, Dan Dubinsky, Jason Purnell, Keith Keller, Samuel H. Sturner, Elizabeth Grinkevich, Ayan Ghoshal, Amanda Kotek, Giorgio Trivioli, Nathan Richoz, Mary B. Humphrey, Isabella G. Darby, Sarah J. Miller, Yingping Xu, Astrid Weins, Alexandra Chloe-Villani, Steven L. Chang, Matthias Kretzler, Orit Rosenblatt-Rosen, Jillian L. Shaw, Kurt A. Zimmerman, Menna R. Clatworthy, Aviv Regev, Anna Greka
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114253- (2024)
Summary: Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt its progression are lacking. We analyze kidney single-cell transcriptomic profile
Externí odkaz:
https://doaj.org/article/c26ba69a6afe47bdbc7deb8408bb9ad1
Autor:
Stefano Suzzi, Tommaso Croese, Adi Ravid, Or Gold, Abbe R. Clark, Sedi Medina, Daniel Kitsberg, Miriam Adam, Katherine A. Vernon, Eva Kohnert, Inbar Shapira, Sergey Malitsky, Maxim Itkin, Alexander Brandis, Tevie Mehlman, Tomer M. Salame, Sarah P. Colaiuta, Liora Cahalon, Michal Slyper, Anna Greka, Naomi Habib, Michal Schwartz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Obesity and aging increase Alzheimer’s disease (AD) risk. Here, using an AD mouse model and high-fat diet, we suggest that immune exhaustion links the two risk factors, and identify a metabolite that can hasten immune dysfunction and memory deficit
Externí odkaz:
https://doaj.org/article/f63e1c3be52546e8ab1f362761e300d0
Autor:
Tallulah S. Andrews, Jawairia Atif, Jeff C. Liu, Catia T. Perciani, Xue‐Zhong Ma, Cornelia Thoeni, Michal Slyper, Gökcen Eraslan, Asa Segerstolpe, Justin Manuel, Sai Chung, Erin Winter, Iulia Cirlan, Nicholas Khuu, Sandra Fischer, Orit Rozenblatt‐Rosen, Aviv Regev, Ian D. McGilvray, Gary D. Bader, Sonya A. MacParland
Publikováno v:
Hepatology Communications, Vol 6, Iss 4, Pp 821-840 (2022)
The critical functions of the human liver are coordinated through the interactions of hepatic parenchymal and non‐parenchymal cells. Recent advances in single‐cell transcriptional approaches have enabled an examination of the human liver with unp
Externí odkaz:
https://doaj.org/article/f4baa4210df8450382ddc9b9cbc1c1e2
Autor:
Ayshwarya Subramanian, Eriene-Heidi Sidhom, Maheswarareddy Emani, Katherine Vernon, Nareh Sahakian, Yiming Zhou, Maria Kost-Alimova, Michal Slyper, Julia Waldman, Danielle Dionne, Lan T. Nguyen, Astrid Weins, Jamie L. Marshall, Orit Rosenblatt-Rosen, Aviv Regev, Anna Greka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
How reproducible human kidney organoids derived from different iPSC lines are, and how faithful they are to human kidney tissue remain unclear. Here, the authors use four human iPSC lines to derive kidney organoids and show how organoid composition i
Externí odkaz:
https://doaj.org/article/fec9d1d79cc3436c8e6951c9b267d13d
Autor:
Alejandro Martinez Chibly, Alice Shia, Radia Johnson, Michael S. Hwang, Marc Hafner, Ciara Metcalfe, Kalpit Shah, Michal Slyper, Chris Bolen, Sarah E. Pinder, Alastair M. Thompson, Steven Gendreau, Peter Schmid
Publikováno v:
Cancer Research. 83:PD10-06
Background: Endocrine therapy (ET) is the mainstay of ER+ BC treatment. However; up to 20% of ER+ BC tumors progress into metastatic disease and develop ET resistance, underscoring the need for combination therapies. Preclinical data suggest that com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ae27e55314cc75a761628cd0c57514d
https://doi.org/10.1158/1538-7445.sabcs22-pd10-06
https://doi.org/10.1158/1538-7445.sabcs22-pd10-06
Autor:
Ittai Ben-Porath, Tamar Peretz, Bella Maly, Tamar Hamburger, Roy Z. Granit, Anat Bar-Ziv, Amit Shahar, Michal Slyper
PDF file - 168K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f90c017ca5ca60b4c64a99dc656fb4
https://doi.org/10.1158/0008-5472.22393332.v1
https://doi.org/10.1158/0008-5472.22393332.v1
Autor:
Ittai Ben-Porath, Tamar Peretz, Bella Maly, Tamar Hamburger, Roy Z. Granit, Anat Bar-Ziv, Amit Shahar, Michal Slyper
PDF file - 9.8MB, Supplementary Figure S1. TCF3 expression levels in breast cancer cell lines. Supplementary Figure S2. Effects of TCF3 on cell proliferation, apoptosis and tumor growth. Supplementary Figure S3. TCF3 induces changes in the expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f9e0bb87fb12d7d96444b69a9f978e
https://doi.org/10.1158/0008-5472.22393338
https://doi.org/10.1158/0008-5472.22393338
Autor:
Ittai Ben-Porath, Tamar Peretz, Bella Maly, Tamar Hamburger, Roy Z. Granit, Anat Bar-Ziv, Amit Shahar, Michal Slyper
PDF file - 33K, Wnt-responsive genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f768cffe2df02b8415896b4d6d3e6a
https://doi.org/10.1158/0008-5472.22393335.v1
https://doi.org/10.1158/0008-5472.22393335.v1
Autor:
Diane Zhang, Asa Segerstolpe, Michal Slyper, Julia Waldman, Evan Murray, Ofir Cohen, Orr Ashenberg, Daniel Abravanel, Judit Jané-Valbuena, Simon Mages, Ana Lako, Karla Helvie, Orit Rozenblatt-Rosen, Scott Rodig, Fei Chen, Nikhil Wagle, Aviv Regev, Johanna Klughammer
Solid tumors are spatially heterogeneous in their genetic, molecular and cellular composition, and this variation can be meaningful for diagnosis, prognosis and therapy. Recent spatial profiling studies have mostly charted genetic and RNA variation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3905933c0ccfb964134abc2d3ea114c
https://doi.org/10.1101/2022.11.25.517982
https://doi.org/10.1101/2022.11.25.517982
Autor:
Yered Pita-Juarez, Dimitra Karagkouni, Nikolaos Kalavros, Johannes C. Melms, Sebastian Niezen, Toni M. Delorey, Adam L Essene, Olga R. Brook, Deepti Pant, Disha Skelton-Badlani, Pourya Naderi, Pinzhu Huang, Liuliu Pan, Tyler Hether, Tallulah S. Andrews, Carly G.K. Ziegler, Jason Reeves, Andriy Myloserdnyy, Rachel Chen, Andy Nam, Stefan Phelan, Yan Liang, Amit Dipak Amin, Jana Biermann, Hanina Hibshoosh, Molly Veregge, Zachary Kramer, Christopher Jacobs, Yusuf Yalcin, Devan Phillips, Michal Slyper, Ayshwarya Subramanian, Orr Ashenberg, Zohar Bloom-Ackermann, Victoria M. Tran, James Gomez, Alexander Sturm, Shuting Zhang, Stephen J. Fleming, Sarah Warren, Joseph Beechem, Deborah Hung, Mehrtash Babadi, Robert F. Padera, Sonya A. MacParland, Gary D. Bader, Nasser Imad, Isaac H. Solomon, Eric Miller, Stefan Riedel, Caroline B.M. Porter, Alexandra-Chloé Villani, Linus T.-Y. Tsai, Winston Hide, Gyongyi Szabo, Jonathan Hecht, Orit Rozenblatt-Rosen, Alex K. Shalek, Benjamin Izar, Aviv Regev, Yury Popov, Z. Gordon Jiang, Ioannis S. Vlachos
Publikováno v:
bioRxiv : the preprint server for biology.
The molecular underpinnings of organ dysfunction in acute COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these in the context of liver function, we performed single-nucleus RNA-seq and spatial transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd10833ef100648eb315ed90fe2285a
https://pubmed.ncbi.nlm.nih.gov/36324805
https://pubmed.ncbi.nlm.nih.gov/36324805