Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michal Siller"'
Autor:
Zuzana Matuskova, Pavel Anzenbacher, Helena Tlaskalova-Hogenova, Rostislav Vecera, Michal Siller, Jan Strojil, Eva Anzenbacherova
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 42:29-36
The probiotic bacterium Escherichia coli strain Nissle 1917 has previously been shown to alter the pharmacokinetics of amiodarone. The aim of this study was to determine whether the probiotic bacterium Lactobacillus casei produces similar alterations
Publikováno v:
Xenobiotica. 46:315-324
1. The aim of this work was to examine the differences in the inhibitory potency of individual enantiomers and racemic mixtures of selected chiral drugs on human liver microsomal cytochromes P450. 2. The interaction of enantiomeric forms of six drugs
Publikováno v:
Xenobiotica. 41:934-944
Neutrophil growth factors (NGFs) stimulate neutrophil growth and survival. The first synthetic cytokinin-derived NGF was recently discovered and is a prospective drug owing to its potential use in anti-inflammatory therapy. The metabolism of some cyt
Autor:
Eva Anzenbacherova, Michal Siller, Kamil Kuca, Alena Veinlichová, Josef Fusek, Daniel Jun, Petra Jancova, Pavel Anzenbacher
Publikováno v:
Chemico-Biological Interactions. 180:449-453
Substances K-48 and HI-6, oxime-type acetylcholinesterase (AChE) reactivators, were tested for their potential to inhibit the activities of human liver microsomal cytochromes P450 (CYP). The compounds were shown to bind to microsomal cytochromes P450
Autor:
Pavla Perlíková, Petr Nauš, Gabriela Rylova, Michal Siller, Marian Hajduch, Eva Tloušťová, Petr Džubák, Aurelie Bourderioux, Alice Nova, Dalibor Doležal, Tomáš Elbert, Jan Hlaváč, Kamil Motyka, Lenka Poštová Slavětínská, Michal Hocek, Monika Harvanova, Pawel Znojek
Publikováno v:
Molecular cancer therapeutics. 15(5)
7-(2-Thienyl)-7-deazaadenosine (AB61) showed nanomolar cytotoxic activities against various cancer cell lines but only mild (micromolar) activities against normal fibroblasts. The selectivity of AB61 was found to be due to inefficient phosphorylation
Publikováno v:
The FASEB Journal. 28
Cytochrome P450 (P450) 2U1 has been shown to be expressed (at the mRNA level) in human brain and thymus. In order to elucidate the physiological function of this enzyme, an LC-MS-based metabolomics...
Autor:
Rostislav, Vecera, Alice, Zacharová, Michal, Siller, Zuzana, Matuskova, Nina, Skottová, Eva, Anzenbacherová, Pavel, Anzenbacher
Publikováno v:
Neuro endocrinology letters. 33
The aim of this study was to investigate whether rosuvastatin affects expression and activity of rat CYP2C6. This cytochrome P450 is considered to be a counterpart of human CYP2C9, which metabolizes many drugs, including diclofenac, ibuprofen or warf
Autor:
Eva Anzenbacherová, Alice Zachařová, Alena Špičáková, Pavel Anzenbacher, Michal Siller, Nina Škottová, Rostislav Večeřa
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 42(8)
The aim was to investigate whether rosuvastatin affect rat cytochrome P450 (CYP) 2C11 and CYP2C6. CYP2C11 and CYP2C6 are considered as counterparts of human CYP2C9, which metabolizes many drugs including S-warfarin, diclofenac or ibuprofen. The male
Autor:
Petra Jancova, Michal Siller
Publikováno v:
Topics on Drug Metabolism
All organisms are constantly and unavoidably exposed to xenobiotics including both man–made and natural chemicals such as drugs, plant alkaloids, microorganism toxins, pollutants, pesticides, and other industrial chemicals. Formally, biotransformat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5979db98bb8c7b67fc8d8786ee68394
http://www.intechopen.com/articles/show/title/phase-ii-drug-metabolism
http://www.intechopen.com/articles/show/title/phase-ii-drug-metabolism
Autor:
Zuzana, Matuskova, Michal, Siller, Alena, Tunkova, Eva, Anzenbacherova, Alice, Zacharova, Helena, Tlaskalova-Hogenova, Zdenek, Zidek, Pavel, Anzenbacher
Publikováno v:
Neuro endocrinology letters. 32
The aim of the study was to find whether probiotic Lactobacillus casei influences the expression or the activity of cytochromes P450 (CYP) and whether it has an influence on the level of CYP mRNA in male rats.Live bacterial suspension of L. casei was