Výsledky vyhledávání - "Michal Shreberk"

Akademický článek

Deciphering the involvement of the Hippo pathway co-regulators, YAP/TAZ in invadopodia formation and matrix degradation

Autor: Jubina Balan Venghateri, Bareket Dassa, David Morgenstern, Michal Shreberk-Shaked, Moshe Oren, Benjamin Geiger

Publikováno v: Cell Death and Disease, Vol 14, Iss 4, Pp 1-14 (2023)

Abstract Invadopodia are adhesive, actin-rich protrusions formed by metastatic cancer cells that degrade the extracellular matrix and facilitate invasion. They support the metastatic cascade by a spatially and temporally coordinated process whereby i

Externí odkaz: https://doaj.org/article/33ec5b5da08f49ebae6e9eafb0799ded

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Akademický článek

Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

The differential effects of TP53 missense mutations in colorectal cancer (CRC) remain to be explored. Here the authors compare the gain of function impact of two frequent TP53 mutations in CRC and show that p53R273 mutants control a transcriptional p

Externí odkaz: https://doaj.org/article/a119b82dad0a479ebb369694272fe374

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Akademický článek

New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?

Autor: Michal Shreberk‐Shaked, Moshe Oren

Publikováno v: Molecular Oncology, Vol 13, Iss 6, Pp 1335-1341 (2019)

Yes‐associated protein (YAP) and transcriptional co‐activator with PDZ‐binding motif (TAZ), the main effectors of the Hippo pathway, are emerging as important players in cancer biology and therapy response. The intracellular localization of YAP

Externí odkaz: https://doaj.org/article/46509c7b3a974340b72cbbe4d637c904

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Data from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer

Autor: Moshe Oren, Eytan Ruppin, Giovanni Blandino, Yael Aylon, Saptaparna Mukherjee, Ido Azuri, Silvia Di Agostino, Sanju Sinha, Bareket Dassa, Michal Shreberk-Shaked

Lung cancer is the leading cause of cancer-related deaths worldwide. The paralogous transcriptional cofactors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ, also called WWTR1), the main downstream effectors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7ba38facb92c775aa224d94c378c62
https://doi.org/10.1158/0008-5472.c.6512052

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Table S2: List of YAP-differential and TAZ-differential drugs from A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer

Autor: Moshe Oren, Eytan Ruppin, Giovanni Blandino, Yael Aylon, Saptaparna Mukherjee, Ido Azuri, Silvia Di Agostino, Sanju Sinha, Bareket Dassa, Michal Shreberk-Shaked

List of 142 YAP-differential drugs and 38 TAZ-differential drugs in LUAD cells. Each row is a drug, and each column specifies additional information, including dose used in the screen, drug targets, indication, clinical phase and the p-value of the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefb7f5c4f46230d9b85c7247d931217
https://doi.org/10.1158/0008-5472.22425495.v1

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Deciphering the involvement of the Hippo pathway co-regulators, YAP/TAZ in invadopodia formation and matrix degradation

Autor: Jubina Balan Venghateri, Bareket Dassa, David Morgenstern, Michal Shreberk-Shaked, Moshe Oren, Benjamin Geiger

Invadopodia are adhesive, actin-rich protrusions formed by metastatic cancer cells that degrade the extracellular matrix and facilitate invasion. They support the metastatic cascade by a spatially and temporally coordinated process whereby invading c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f882a8fbc420e8d21e667c7074b615
https://doi.org/10.21203/rs.3.rs-1948766/v1

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