Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Michal R Schweiger"'
Autor:
Claudia Perne, Sophia Peters, Maria Cartolano, Sukanya Horpaopan, Christina Grimm, Janine Altmüller, Anna K Sommer, Axel M Hillmer, Holger Thiele, Margarete Odenthal, Gabriela Möslein, Ronja Adam, Sugirthan Sivalingam, Jutta Kirfel, Michal R Schweiger, Martin Peifer, Isabel Spier, Stefan Aretz
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259185 (2021)
The spectrum of somatic genetic variation in colorectal adenomas caused by biallelic pathogenic germline variants in the MSH3 gene, was comprehensively analysed to characterise mutational signatures and identify potential driver genes and pathways of
Externí odkaz:
https://doaj.org/article/6bc898b6a61f4b74a29ec7af0aec5145
Autor:
Lukasz A Kacprzyk, Mark Laible, Tatjana Andrasiuk, Jan C Brase, Stefan T Börno, Maria Fälth, Ruprecht Kuner, Hans Lehrach, Michal R Schweiger, Holger Sültmann
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59976 (2013)
Overexpression of ERG transcription factor due to genomic ERG-rearrangements defines a separate molecular subtype of prostate tumors. One of the consequences of ERG accumulation is modulation of the cell's gene expression profile. Tudor domain-contai
Externí odkaz:
https://doaj.org/article/bc73dd54cbf64c3282e34c10879b0be8
Autor:
Christina Röhr, Martin Kerick, Axel Fischer, Alexander Kühn, Karl Kashofer, Bernd Timmermann, Andriani Daskalaki, Thomas Meinel, Dmitriy Drichel, Stefan T Börno, Anja Nowka, Sylvia Krobitsch, Alice C McHardy, Christina Kratsch, Tim Becker, Andrea Wunderlich, Christian Barmeyer, Christian Viertler, Kurt Zatloukal, Christoph Wierling, Hans Lehrach, Michal R Schweiger
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67461 (2013)
MiRNAs are discussed as diagnostic and therapeutic molecules. However, effective miRNA drug treatments with miRNAs are, so far, hampered by the complexity of the miRNA networks. To identify potential miRNA drugs in colorectal cancer, we profiled miRN
Externí odkaz:
https://doaj.org/article/863b3241ed1442a78654292661e1358f
Autor:
Christina Grimm, Lukas Chavez, Mireia Vilardell, Alexandra L Farrall, Sascha Tierling, Julia W Böhm, Phillip Grote, Matthias Lienhard, Jörn Dietrich, Bernd Timmermann, Jörn Walter, Michal R Schweiger, Hans Lehrach, Ralf Herwig, Bernhard G Herrmann, Markus Morkel
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003250 (2013)
Aberrant CpG methylation is a universal epigenetic trait of cancer cell genomes. However, human cancer samples or cell lines preclude the investigation of epigenetic changes occurring early during tumour development. Here, we have used MeDIP-seq to a
Externí odkaz:
https://doaj.org/article/f1689bb6ce554651818e5958827f19fb
Autor:
Bernd Timmermann, Martin Kerick, Christina Roehr, Axel Fischer, Melanie Isau, Stefan T Boerno, Andrea Wunderlich, Christian Barmeyer, Petra Seemann, Jana Koenig, Michael Lappe, Andreas W Kuss, Masoud Garshasbi, Lars Bertram, Kathrin Trappe, Martin Werber, Bernhard G Herrmann, Kurt Zatloukal, Hans Lehrach, Michal R Schweiger
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15661 (2010)
BACKGROUND: Colorectal cancer (CRC) is with approximately 1 million cases the third most common cancer worldwide. Extensive research is ongoing to decipher the underlying genetic patterns with the hope to improve early cancer diagnosis and treatment.
Externí odkaz:
https://doaj.org/article/0b8938033d6d40579eacc99fc53f2fbc
Autor:
Michal R Schweiger, Martin Kerick, Bernd Timmermann, Marcus W Albrecht, Tatjana Borodina, Dmitri Parkhomchuk, Kurt Zatloukal, Hans Lehrach
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5548 (2009)
BACKGROUND: Cancer re-sequencing programs rely on DNA isolated from fresh snap frozen tissues, the preparation of which is combined with additional preservation efforts. Tissue samples at pathology departments are routinely stored as formalin-fixed a
Externí odkaz:
https://doaj.org/article/a8175db6c026449c997ff6f24caaed2d
Autor:
Karem Awad, Christian Barmeyer, Christian Bojarski, Oliver Nagel, In-Fah M. Lee, Michal R. Schweiger, Jörg-Dieter Schulzke, Roland Bücker
Publikováno v:
Cells, Vol 12, Iss 24, p 2846 (2023)
Background: In patients with diarrhea-predominant irritable bowel syndrome (IBS-D), the diarrheal mechanisms are largely unknown, and they were examined in this study on colon biopsies. Methods: Electrophysiological measurements were used for monitor
Externí odkaz:
https://doaj.org/article/617ff395507043f5b1568681be88f5b2
Autor:
Joelle Noriko Galang, Yefeng Shen, Ulrike Koitzsch, Xiaojie Yu, Hannah Eischeid-Scholz, Daniel Bachurski, Tilman T. Rau, Christina Neppl, Marco Herling, Bianca Bulimaga, Elena Vasyutina, Michal R. Schweiger, Reinhard Büttner, Margarete Odenthal, Maria M. Anokhina
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13981 (2023)
Lysine-specific demethylase 1 (LSD1) is highly expressed in many cancer types and strongly associated with cancer progression and metastasis. Circular RNAs (circRNAs) are produced by back-splicing and influence the interactive RNA network by microRNA
Externí odkaz:
https://doaj.org/article/cfb1dfa8d7dc4e1394482e1ade878ef4
Autor:
Julian Kanne, Michelle Hussong, Jörg Isensee, Álvaro Muñoz-López, Jan Wolffgramm, Felix Heß, Christina Grimm, Sergey Bessonov, Lydia Meder, Jie Wang, H. Christian Reinhardt, Margarete Odenthal, Tim Hucho, Reinhard Büttner, Daniel Summerer, Michal R. Schweiger
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-15 (2021)
Abstract Non-coding RNA from pericentromeric satellite repeats are involved in stress-dependent splicing processes, maintenance of heterochromatin, and are required to protect genome stability. Here we show that the long non-coding satellite III RNA
Externí odkaz:
https://doaj.org/article/0959e03a10f843b1a00d0335705383db
Autor:
Karem Awad, Christian Barmeyer, Christian Bojarski, Oliver Nagel, In-Fah M. Lee, Michal R. Schweiger, Jörg-Dieter Schulzke, Roland Bücker
Publikováno v:
Cells, Vol 12, Iss 2, p 236 (2023)
Background: The underlying pathophysiology of irritable bowel syndrome (IBS) is still unclear. Our aim was to investigate the pathophysiological mechanisms of diarrhea, constipation, and antigen uptake in mixed-type IBS (IBS-M). Methods: Colonoscopic
Externí odkaz:
https://doaj.org/article/6dc6f099552e46198939f9832ba91002