Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Michal Pyzik"'
Autor:
Michal Pyzik, Kine M. K. Sand, Jonathan J. Hubbard, Jan Terje Andersen, Inger Sandlie, Richard S. Blumberg
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids. Although IgG alone can directly protect the body from infection through the
Externí odkaz:
https://doaj.org/article/27e7fa5563db47e0ae8292d94df0547e
Autor:
Grégory Caignard, Gabriel A Leiva-Torres, Michael Leney-Greene, Benoit Charbonneau, Anne Dumaine, Nassima Fodil-Cornu, Michal Pyzik, Pablo Cingolani, Jeremy Schwartzentruber, Jeremy Dupaul-Chicoine, Huaijian Guo, Maya Saleh, André Veillette, Marc Lathrop, Mathieu Blanchette, Jacek Majewski, Angela Pearson, Silvia M Vidal
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003637 (2013)
Herpes simplex encephalitis (HSE) is a lethal neurological disease resulting from infection with Herpes Simplex Virus 1 (HSV-1). Loss-of-function mutations in the UNC93B1, TLR3, TRIF, TRAF3, and TBK1 genes have been associated with a human genetic pr
Externí odkaz:
https://doaj.org/article/cde333edced84b53aa1844cc39d31dbf
Publikováno v:
Nature Reviews Immunology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b020927ab99eb77dfd33237ca2048e9d
https://doi.org/10.1038/s41577-022-00821-1
https://doi.org/10.1038/s41577-022-00821-1
Autor:
Jinzhi Duan, Juan D. Matute, Lukas W. Unger, Thomas Hanley, Alexandra Schnell, Xi Lin, Niklas Krupka, Paul Griebel, Conner Lambden, Brandon Sit, Joep Grootjans, Michal Pyzik, Felix Sommer, Sina Kaiser, Maren Falk-Paulsen, Helmut Grasberger, John Y. Kao, Tobias Fuhrer, Hai Li, Donggi Paik, Yunjin Lee, Samuel Refetoff, Jonathan N. Glickman, Adrienne W. Paton, Lynn Bry, James C. Paton, Uwe Sauer, Andrew J. Macpherson, Philip Rosenstiel, Vijay K. Kuchroo, Matthew K. Waldor, Jun R. Huh, Arthur Kaser, Richard S. Blumberg
Publikováno v:
Immunity, 56(5), 1115-1131.e9. Cell Press
Intestinal IL-17-producing T helper (Th17) cells are dependent on adherent microbes in the gut for their development. However, how microbial adherence to intestinal epithelial cells (IECs) promotes Th17 cell differentiation remains enigmatic. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcd3323c2cd92a9cd5fa93839796145
Autor:
Mortimer Poncz, Amrita Sarkar, Douglas B. Cines, Alan E. Mast, Sriram Krishnaswamy, Jonathan J. Hubbard, Keith R. McCrae, M. Anna Kowalska, Guohua Zhao, Richard S. Blumberg, Victoria Stepanova, Lubica Rauova, Laurence J. Blumberg, Michal Pyzik, Ann H. Rux, Sergei Zaitsev
Publikováno v:
Blood
Thromboembolism complicates disorders caused by immunoglobulin G (IgG)–containing immune complexes (ICs), but the underlying mechanisms are incompletely understood. Prior evidence indicates that induction of tissue factor (TF) on monocytes, a pivot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a523d72fd38bec0bed017bf44acb364
https://europepmc.org/articles/PMC7273830/
https://europepmc.org/articles/PMC7273830/
Autor:
Kristi Baker, Susan C. Menzies, Edda Fiebiger, Jan Terje Andersen, Jonathan N. Glickman, Lisa K. Kozicky, Laura M. Sly, Algirdas Grevys, Michal Pyzik, Timo Rath, Jonathan J. Hubbard, Inger Sandlie, Richard S. Blumberg, Amit Gandhi, Derry C. Roopenian, Stian Foss, Kine Marita Knudsen Sand
Publikováno v:
The Journal of Experimental Medicine
FcRn and CD32a form a ternary complex under acidic conditions and act together in determining responses to IgG immune complexes. The human autoimmune disease–associated CD32a-H131 variant more avidly forms this ternary complex, leading to greater F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a83bcb1e05ae287515bff8e097ff5d3
https://pubmed.ncbi.nlm.nih.gov/32658257
https://pubmed.ncbi.nlm.nih.gov/32658257
Autor:
Donna A. Culton, Michal Pyzik, Richard S. Blumberg, Victoria P. Werth, Russell P. Hall, James S. Graydon, Joyce Okawa, Laurence J. Blumberg, Josef Symon S. Concha
Publikováno v:
Journal of Investigative Dermatology. 141:2858-2865.e4
Pemphigus is a debilitating IgG-mediated autoimmune disease requiring better tolerated, more targeted, and rapid onset therapies. ALXN1830 is a humanized IgG4 antibody that blocks neonatal Fc receptor interactions with IgG. A multicenter, open-label
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05bacceb6a223f5a5fc3d4b102aa6c4
https://doi.org/10.1016/j.jid.2021.04.031
https://doi.org/10.1016/j.jid.2021.04.031
Autor:
S Purohit, K Lasseter, Amit Gandhi, Derry C. Roopenian, Robert George Edward Holgate, Jonathan J. Hubbard, J E Humphries, L E Stolz, Jan Terje Andersen, Michal Pyzik, Atiya Mahmood, D de Graaf, Susan D. Jones, Arron Hearn, Alan J. Bitonti, J S Graydon, Richard S. Blumberg, K Kacena, Laurence J. Blumberg, Gregory J. Christianson, B Del Tito, L B Pearce, J. Cheung
Publikováno v:
Science Advances
Therapeutic blockade of FcRn in humans decreases IgG and IgG immune complex levels with the attendant immunologic implications.
The neonatal crystallizable fragment receptor (FcRn) functions as an intracellular protection receptor for immunoglob
The neonatal crystallizable fragment receptor (FcRn) functions as an intracellular protection receptor for immunoglob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7956be3e71940724cce8ce3634ea7a40
http://hdl.handle.net/10852/76135
http://hdl.handle.net/10852/76135
Publikováno v:
The Journal of Immunology. 194:4595-4603
The neonatal FcR (FcRn) belongs to the extensive and functionally divergent family of MHC molecules. Contrary to classical MHC family members, FcRn possesses little diversity and is unable to present Ags. Instead, through its capacity to bind IgG and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3275c5cc03019de8e0d78df6d31e76
https://doi.org/10.4049/jimmunol.1403014
https://doi.org/10.4049/jimmunol.1403014
Autor:
Atsushi Mizoguchi, Jonathan J. Hubbard, Sanda Win, Neil Kaplowitz, Shalaka Purohit, Kevin Mcdonnell, Zachary Taylor, Thomas D Krämer, Jan Terje Andersen, Richard S. Blumberg, Kristi Baker, Inger Sandlie, Timothy Kuo, Michal Pyzik, Vicki L. Nienaber, Timo Rath, Rosa Grenha, Adam R. Mezo, Gregory J. Christianson, Amit Gandhi, Derry C. Roopenian, Laurence J. Blumberg, Susan D. Jones, Wayne I. Lencer
The neonatal crystallizable fragment receptor (FcRn) is responsible for maintaining the long half-life and high levels of the two most abundant circulating proteins, albumin and IgG. In the latter case, the protective mechanism derives from FcRn bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6ac46c6ac166e9ae126be1d40a73e1
https://europepmc.org/articles/PMC5389309/
https://europepmc.org/articles/PMC5389309/