Zobrazeno 1 - 10
of 299
pro vyhledávání: '"Michal Pravenec"'
Autor:
Petr Pecina, Kristýna Čunátová, Vilma Kaplanová, Guillermo Puertas-Frias, Jan Šilhavý, Kateřina Tauchmannová, Marek Vrbacký, Tomáš Čajka, Ondřej Gahura, Markéta Hlaváčková, Viktor Stránecký, Stanislav Kmoch, Michal Pravenec, Josef Houštěk, Tomáš Mráček, Alena Pecinová
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Metabolic syndrome is a growing concern in developed societies and due to its polygenic nature, the genetic component is only slowly being elucidated. Common mitochondrial DNA sequence variants have been associated with symptoms of metabolic
Externí odkaz:
https://doaj.org/article/d3f3d37db99e40758be1699d25e767e2
Autor:
Ivana Nemeckova, Samira Eissazadeh, Jana Urbankova Rathouska, Jan Silhavy, Hana Malinska, Michal Pravenec, Petr Nachtigal
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background C-reactive protein (CRP) is an acute inflammatory protein detected in obese patients with metabolic syndrome. Moreover, increased CRP levels have been linked with atherosclerotic disease, congestive heart failure, and ischemic hea
Externí odkaz:
https://doaj.org/article/64bd60ec726e4193987ffab338abf635
Autor:
Martina Hüttl, Irena Markova, Denisa Miklánková, Iveta Zapletalova, Petr Kujal, Jan Šilhavý, Michal Pravenec, Hana Malinska
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background and aims: Low-grade chronic inflammation plays an important role in the pathogenesis of metabolic syndrome, type 2 diabetes and their complications. In this study, we investigated the effects of salsalate, a non-steroidal anti-inflammatory
Externí odkaz:
https://doaj.org/article/43d18ec3736b4092867a31a16cc3da06
Autor:
Jan Silhavy, Petr Mlejnek, Miroslava Šimáková, Irena Marková, Hana Malínská, Martina Hüttl, Ludmila Kazdová, Dmitry Kazantsev, Massimiliano Mancini, Jiří Novotný, Michal Pravenec
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283276 (2023)
Thermogenesis in brown adipose tissue (BAT) uses intracellular triglycerides, circulating free fatty acids and glucose as the main substrates. The objective of the current study was to analyse the role of CD36 fatty acid translocase in regulation of
Externí odkaz:
https://doaj.org/article/35b76587320949d6a94477eed4b50a5f
Autor:
Franziska Witte, Jorge Ruiz-Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig, Leonardo Bottolo, Daniel Sanchis, Martin Vingron, Marina Chekulaeva, Michal Pravenec, Norbert Hubner, Sebastiaan van Heesch
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-34 (2021)
Abstract Background Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the influence of such distant genetic loci on the efficiency of mRNA translatio
Externí odkaz:
https://doaj.org/article/19d7de0ec8794ef6952216fe9ea71d99
Autor:
Ondrej Mihola, Vladimir Landa, Florencia Pratto, Kevin Brick, Tatyana Kobets, Fitore Kusari, Srdjan Gasic, Fatima Smagulova, Corinne Grey, Petr Flachs, Vaclav Gergelits, Karel Tresnak, Jan Silhavy, Petr Mlejnek, R. Daniel Camerini-Otero, Michal Pravenec, Galina V. Petukhova, Zdenek Trachtulec
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background Vertebrate meiotic recombination events are concentrated in regions (hotspots) that display open chromatin marks, such as trimethylation of lysines 4 and 36 of histone 3 (H3K4me3 and H3K36me3). Mouse and human PRDM9 proteins catal
Externí odkaz:
https://doaj.org/article/03a0d82fd99840bf996152ad7bf19c03
Autor:
Anna N Senko, Rupert W Overall, Jan Silhavy, Petr Mlejnek, Hana Malínská, Martina Hüttl, Irena Marková, Klaus S Fabel, Lu Lu, Ales Stuchlik, Robert W Williams, Michal Pravenec, Gerd Kempermann
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1009638 (2022)
Neurogenesis in the adult hippocampus contributes to learning and memory in the healthy brain but is dysregulated in metabolic and neurodegenerative diseases. The molecular relationships between neural stem cell activity, adult neurogenesis, and glob
Externí odkaz:
https://doaj.org/article/888d224e99174f44824dc55a14e63450
Autor:
Ryan Lusk, Paula L. Hoffman, Spencer Mahaffey, Samuel Rosean, Harry Smith, Jan Silhavy, Michal Pravenec, Boris Tabakoff, Laura M. Saba
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Post transcriptional modifications of RNA are powerful mechanisms by which eukaryotes expand their genetic diversity. For instance, researchers estimate that most transcripts in humans undergo alternative splicing and alternative polyadenylation. The
Externí odkaz:
https://doaj.org/article/75e02fa602fb446085e3faeeaa0486aa
Autor:
Jan Šilhavý, Petr Mlejnek, Miroslava Šimáková, Hana Malínská, Irena Marková, Martina Hüttl, Denisa Miklánková, Ludmila Kazdová, Marek Vrbacký, Alena Pecinová, Tomáš Mráček, Michal Pravenec
Publikováno v:
Metabolites, Vol 13, Iss 2, p 192 (2023)
Recently, red beetroot has attracted attention as a health-promoting functional food. Studies have shown that beetroot administration can reduce blood pressure and ameliorate parameters of glucose and lipid metabolism; however, mechanisms underlying
Externí odkaz:
https://doaj.org/article/a687dbf6a0cc4fd38db94b4d81c78b08
Autor:
Huimei Chen, Aida Moreno-Moral, Francesco Pesce, Nithya Devapragash, Massimiliano Mancini, Ee Ling Heng, Maxime Rotival, Prashant K. Srivastava, Nathan Harmston, Kirill Shkura, Owen J. L. Rackham, Wei-Ping Yu, Xi-Ming Sun, Nicole Gui Zhen Tee, Elisabeth Li Sa Tan, Paul J. R. Barton, Leanne E. Felkin, Enrique Lara-Pezzi, Gianni Angelini, Cristina Beltrami, Michal Pravenec, Sebastian Schafer, Leonardo Bottolo, Norbert Hubner, Costanza Emanueli, Stuart A. Cook, Enrico Petretto
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Pathological cardiac fibrosis is a hallmark of diseases leading to heart failure. Here, the authors used systems genetics to identify a pro-fibrotic gene network regulated by WWP2, a E3 ubiquitin ligase, which orchestrates the nucleocytoplasmic shutt
Externí odkaz:
https://doaj.org/article/cfb1b8ece2684ea692a537c58f79dad3