Výsledky vyhledávání - "Michal Pearl Yafe"

Participation of Adult Bone Marrow-Derived Stem Cells in Pancreatic Regeneration: Neogenesis Versus Endogenesis

Autor: Ayelet Kaminitz, Jerry Stein, Keren Mizrahi, Michal Pearl Yafe, Svetlana Iskovich, Isaac Yaniv, Nadir Askenasy

Publikováno v: Current Stem Cell Research & Therapy. 2:272-279

Regenerative medicine opens new avenues and promises towards more effective therapies for autoimmune disorders. Current therapeutic strategies for type I diabetes focus on three major directions, with distinct advantages and disadvantages: arrest of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c38f04f5c5582c434606cd4d5a36114
https://doi.org/10.2174/157488807782793754

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Fas Ligand Enhances Hematopoietic Cell Engraftment Through Abrogation of Alloimmune Responses and Nonimmunogenic Interactions

Autor: Michal Pearl-Yafe, Jerry Stein, Haval Shirwan, Esma S. Yolcu, Kaplan O, Nadir Askenasy, Isaac Yaniv

Publikováno v: Stem Cells. 25:1448-1455

Early after transplantation, donor lineage-negative bone marrow cells (lin− BMC) constitutively upregulated their expression of Fas ligand (FasL), suggesting an involvement of the Fas/FasL axis in engraftment. Following the observation of impaired

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ef614be9dae1626124105079da266e
https://doi.org/10.1634/stemcells.2007-0013

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INTERFERON-γ AND BACTERIAL LIPOPOLYSACCHARIDE ACT SYNERGISTICALLY ON HUMAN NEUTROPHILS ENHANCING INTERLEUKIN-8, INTERLEUKIN-1β, TUMOR NECROSIS FACTOR-α, AND INTERLEUKIN-12 P70 SECRETION AND PHAGOCYTOSIS VIA UPREGULATION OF TOLL-LIKE RECEPTOR 4

Autor: Michal Pearl-Yafe, Itamar Shalit, Edith Flatau, Sara Werber, Ina Fabian, Drora Halperin

Publikováno v: Shock. 27:226-231

In human neutrophils, interferon (IFN)-γ enhanced the expression of toll-like receptor 4 (TLR4), a crucial component of the signaling receptor complex for bacterial lipopolysaccharide (LPS). Lipopolysaccharide alone did not affect TLR4 expression, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37a5a8df80217d6153a424e75c9b6c86
https://doi.org/10.1097/01.shk.0000239765.80033.37

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Pancreatic Islets Under Attack: Cellular and Molecular Effectors

Autor: Esma S. Yolcu, Jerry Stein, Nadir Askenasy, Isaac Yaniv, Ayelet Kaminitz, Michal Pearl-Yafe

Publikováno v: Current Pharmaceutical Design. 13:749-760

Abundant information is available on the involvement of various cellular and molecular mechanisms in beta cell apoptosis. The experimental evidence is controversial and difficult to reconcile, and the mechanisms of evasion of the autoreactive clones

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9fbf00d3410690ec65d481eefb8a76
https://doi.org/10.2174/138161207780249155

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The dual role of Fas-ligand as an injury effector and defense strategy in diabetes and islet transplantation

Autor: Jerry Stein, Haval Shirwan, Nadir Askenasy, Isaac Yaniv, Michal Pearl-Yafe, Esma S. Yolcu

Publikováno v: BioEssays. 28:211-222

The exact process that leads to the eruption of autoimmune reactions against beta cells and the evolution of diabetes is not fully understood. Macrophages and T cells may launch an initial immune reaction against the pancreatic islets of Langerhans,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c9d5cee1e0bc172ab22060b7b98e7a
https://doi.org/10.1002/bies.20356

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The p38 pathway partially mediates caspase-3 activation induced by reactive oxygen species in Fanconi anemia C cells

Autor: Michal Pearl-Yafe, Ina Fabian, Drora Halperin, Oded Scheuerman

Publikováno v: Biochemical Pharmacology. 67:539-546

Because Fanconi anemia (FA) cells display hypersensitivity to oxidative stress and reactive oxygen species (ROS) that act as second messengers in cellular signaling, we investigated c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e57f2096c20a92675d6cf03ac60485b
https://doi.org/10.1016/j.bcp.2003.09.024

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Tumor necrosis factor receptors support murine hematopoietic progenitor function in the early stages of engraftment

Autor: Jerry Stein, Isaac Yaniv, Haval Shirwan, Nadir Askenasy, Michal Pearl-Yafe, Kaplan O, Esma S. Yolcu, Keren Mizrahi

Publikováno v: Stem cells (Dayton, Ohio). 28(7)

Tumor necrosis factor (TNF) family receptors/ligands are important participants in hematopoietic homeostasis, in particular as essential negative expansion regulators of differentiated clones. As a prominent injury cytokine, TNF-α has been tradition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bff5fe0de5677de021e630a1eedaa4
https://pubmed.ncbi.nlm.nih.gov/20506490

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Fas transduces dual apoptotic and trophic signals in hematopoietic progenitors

Autor: Michal Pearl-Yafe, Esma S. Yolcu, Isaac Yaniv, Haval Shirwan, Daniel L. Farkas, Nadir Askenasy, Jerry Stein

Publikováno v: Stem cells (Dayton, Ohio). 25(12)

Stem cells and progenitors are often required to realize their differentiation potential in hostile microenvironments. The Fas/Fas ligand (FasL) interaction is a major effector pathway of apoptosis, which negatively regulates the expansion of differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c68726fb21d179b9abf9999681c893a
https://pubmed.ncbi.nlm.nih.gov/17872500

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