Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michal Nemergut"'
Autor:
Michal Nemergut, Daniel Pluskal, Jana Horackova, Tereza Sustrova, Jan Tulis, Tomas Barta, Racha Baatallah, Glwadys Gagnot, Veronika Novakova, Marika Majerova, Karolina Sedlackova, Sérgio M. Marques, Martin Toul, Jiri Damborsky, Zbynek Prokop, David Bednar, Yves L. Janin, Martin Marek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract NanoLuc, a superior β-barrel fold luciferase, was engineered 10 years ago but the nature of its catalysis remains puzzling. Here experimental and computational techniques are combined, revealing that imidazopyrazinone luciferins bind to an
Externí odkaz:
https://doaj.org/article/02510bf81fd243d0bfed12a6fdc366d5
Autor:
Michal Nemergut, Sérgio M. Marques, Lukas Uhrik, Tereza Vanova, Marketa Nezvedova, Darshak Chandulal Gadara, Durga Jha, Jan Tulis, Veronika Novakova, Joan Planas-Iglesias, Antonin Kunka, Anthony Legrand, Hana Hribkova, Veronika Pospisilova, Jiri Sedmik, Jan Raska, Zbynek Prokop, Jiri Damborsky, Dasa Bohaciakova, Zdenek Spacil, Lenka Hernychova, David Bednar, Martin Marek
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-25 (2023)
Abstract Background Apolipoprotein E (ApoE) ε4 genotype is the most prevalent risk factor for late-onset Alzheimer’s Disease (AD). Although ApoE4 differs from its non-pathological ApoE3 isoform only by the C112R mutation, the molecular mechanism o
Externí odkaz:
https://doaj.org/article/3de537d320b7425ab0b3c676809f76bd
Publikováno v:
Microbial Cell Factories, Vol 20, Iss 1, Pp 1-13 (2021)
Abstract Alzheimer’s disease (AD) is a chronic neurodegenerative disease associated with the overproduction and accumulation of amyloid-β peptide and hyperphosphorylation of tau proteins in the brain. Despite extensive research on the amyloid-base
Externí odkaz:
https://doaj.org/article/c17f103746eb4bbfb5801cb2e2a7d363
Autor:
Michal Nemergut, Dagmar Sedláková, Gabriela Fabriciová, Dominik Belej, Daniel Jancura, Erik Sedlák
Thermal denaturation of human serum albumin has been the subject of many studies in recent decades, but the results of these studies are often conflicting and inconclusive. To clarify this, we combined different spectroscopic and calorimetric techniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51cc0475d28a6fa62a818b90ce0edf95
Autor:
Michal Nemergut, Daniel Pluskal, Jana Horackova, Tereza Sustrova, Jan Tulis, Tomas Barta, Racha Baatallah, Glwadys Gagnot, Veronika Novakova, Marika Majerova, Sérgio Marques, Martin Toul, Jiri Damborsky, David Bednar, Zbynek Prokop, Yves Janin, Martin Marek
NanoLuc, a superior β-barrel fold luciferase, was engineered 10 years ago but the nature of its catalysis remains puzzling. Here experimental and computational techniques were combined, revealing that imidazopyrazinone luciferins bind to an intra-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcb06097d36634c51b15c0e9ce1e7ce
https://doi.org/10.1101/2022.12.05.519101
https://doi.org/10.1101/2022.12.05.519101
Autor:
Jiri Damborsky, Andrea Schenkmayerova, Martin Marek, Tereza Batkova, Martina Hlozankova, Barbora Liskova, Katerina Sheardova, Radoslav Matej, Michal Nemergut, Dana Vigasova, M. Bartos, Jan Laczó, Michal Sitina, Jakub Hort, Martin Vyhnalek, Radim Jancalek, Ingrid Kovacova
ObjectiveAlthough the link between microbial infections and Alzheimer’s disease (AD) has been demonstrated in multiple studies, the involvement of pathogens in the development of AD remains unclear. Therefore, this theory beckons further systematic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17517682e32ffc76104f4a68a3d02844
https://doi.org/10.1101/2021.11.04.467230
https://doi.org/10.1101/2021.11.04.467230
Autor:
Michal Nemergut, Tereza Batkova, Dana Vigasova, Milan Bartos, Martina Hlozankova, Andrea Schenkmayerova, Barbora Liskova, Katerina Sheardova, Martin Vyhnalek, Jakub Hort, Jan Laczó, Ingrid Kovacova, Michal Sitina, Radoslav Matej, Radim Jancalek, Martin Marek, Jiri Damborsky
Publikováno v:
Science of The Total Environment. 844:157114
Although the link between microbial infections and Alzheimer's disease (AD) has been demonstrated in multiple studies, the involvement of pathogens in the development of AD remains unclear. Here, we investigated the frequency of the 10 most commonly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c363e49e3a81d422b0c27942d98568
https://doi.org/10.1016/j.scitotenv.2022.157114
https://doi.org/10.1016/j.scitotenv.2022.157114
Publikováno v:
Microbial Cell Factories
Microbial Cell Factories, Vol 20, Iss 1, Pp 1-13 (2021)
Microbial Cell Factories, Vol 20, Iss 1, Pp 1-13 (2021)
Alzheimer’s disease (AD) is a chronic neurodegenerative disease associated with the overproduction and accumulation of amyloid-β peptide and hyperphosphorylation of tau proteins in the brain. Despite extensive research on the amyloid-based mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2805103f91b32cf51dd65bd772505590
https://is.muni.cz/publication/1739777
https://is.muni.cz/publication/1739777
Autor:
Florian Kast, Pavol Miškovský, Andreas Plückthun, Jonas V. Schaefer, Michal Nemergut, Gabriel Žoldák, Erik Sedlák
Publikováno v:
Protein Science. 26:2229-2239
Monoclonal antibodies of the immunoglobulin G (IgG) type have become mainstream therapeutics for the treatment of many life-threatening diseases. For their successful application in the clinic and a favorable cost-benefit ratio, the design and formul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfe89eae12300b6c7a22d52c7e69cdaa
https://doi.org/10.1002/pro.3278
https://doi.org/10.1002/pro.3278
Autor:
Michal Nemergut, Daniel Jancura, Veronika Huntosova, Zuzana Jurasekova, Dominik Belej, Georges Wagnières
Publikováno v:
Journal of Inorganic Biochemistry. 174:37-44
The interaction between a ruthenium - based water soluble oxygen probe ([Ru(Phen)3]2+, phen - phenanthroline) and human serum albumin (HSA) was investigated with the aim of describing the influence of HSA on the [Ru(Phen)3]2+ luminescence properties.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c88c74cbbd7e7ed4c8400615802bda52
https://doi.org/10.1016/j.jinorgbio.2017.05.016
https://doi.org/10.1016/j.jinorgbio.2017.05.016