Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Michal Mrug"'
Autor:
Elizabeth J. Wilk, Timothy C. Howton, Jennifer L. Fisher, Vishal H. Oza, Ryan T. Brownlee, Kasi C. McPherson, Hannah L. Cleary, Bradley K. Yoder, James F. George, Michal Mrug, Brittany N. Lasseigne
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-21 (2023)
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is one of the most prevalent monogenic human diseases. It is mostly caused by pathogenic variants in PKD1 or PKD2 genes that encode interacting transmembrane proteins polycystin
Externí odkaz:
https://doaj.org/article/a29d831d0f624c96a1f2239ed4a5233e
Autor:
Alex Yashchenko, Sarah J. Bland, Cheng J. Song, Ummey Khalecha Bintha Ahmed, Rachel Sharp, Isabella G. Darby, Audrey M. Cordova, Morgan E. Smith, Jeremie M. Lever, Zhang Li, Ernald J. Aloria, Shuja Khan, Bibi Maryam, Shanrun Liu, Michael R. Crowley, Kenneth L. Jones, Lauren A. Zenewicz, James F. George, Michal Mrug, David K. Crossman, Katharina Hopp, Stavros Stavrakis, Mary B. Humphrey, Florent Ginhoux, Kurt A. Zimmerman
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Kidney macrophages are comprised of both monocyte-derived and tissue resident populations; however, the heterogeneity of kidney macrophages and factors that regulate their heterogeneity are poorly understood. Herein, we performed single cell RNA sequ
Externí odkaz:
https://doaj.org/article/33bd5d09e8bc4889bac131cdfd30c35a
Autor:
Zhang Li, Kurt A. Zimmerman, Sreelakshmi Cherakara, Phillip H. Chumley, James F. Collawn, Jun Wang, Courtney J. Haycraft, Cheng J. Song, Teresa Chacana, Reagan S. Andersen, Mandy J. Croyle, Ernald J. Aloria, Raksha P. Hombal, Isis N. Thomas, Hanan Chweih, Kristin L. Simanyi, James F. George, John M. Parant, Michal Mrug, Bradley K. Yoder
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 1 (2023)
Externí odkaz:
https://doaj.org/article/d33111929bb3477fae3f2ddadac69a61
Autor:
Michal Mrug, Michelle S. Bloom, Christine Seto, Meenakshi Malhotra, Hossein Tabriziani, Philippe Gauthier, Vicki Sidlow, Trudy McKanna, Paul R. Billings
Publikováno v:
Kidney Medicine, Vol 3, Iss 6, Pp 1050-1056 (2021)
Rationale & Objective: The identification of pathogenic variants in genes associated with chronic kidney disease can provide patients and nephrologists with actionable information to guide diagnoses and therapeutic plans. However, many nephrologists
Externí odkaz:
https://doaj.org/article/f3c39481dd5241c6a546f2f423febeae
Autor:
Ronald D. Perrone, Ali Hariri, Pascal Minini, Curie Ahn, Arlene B. Chapman, Shigeo Horie, Bertrand Knebelmann, Michal Mrug, Albert C.M. Ong, York P.C. Pei, Vicente E. Torres, Vijay Modur, Ronald T. Gansevoort
Publikováno v:
Kidney Medicine, Vol 4, Iss 10, Pp 100538- (2022)
Rationale & Objective: Venglustat, a glucosylceramide synthase inhibitor, inhibits cyst growth and reduces kidney failure in mouse models of autosomal dominant polycystic kidney disease (ADPKD). STAGED-PKD aims to determine the safety and efficacy of
Externí odkaz:
https://doaj.org/article/66ff3b0e6417477da59ccf6a9cdbba1d
Autor:
Mireille El Ters, Pengcheng Lu, Jonathan D. Mahnken, Jason R. Stubbs, Shiqin Zhang, Darren P. Wallace, Jared J. Grantham, Arlene B. Chapman, Vicente E. Torres, Peter C. Harris, Kyongtae Ty Bae, Douglas P. Landsittel, Frederic F. Rahbari-Oskoui, Michal Mrug, William M. Bennett, Alan S.L. Yu
Publikováno v:
Kidney International Reports, Vol 6, Iss 4, Pp 953-961 (2021)
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst growth and a loss of functioning renal mass, but a decline in glomerular filtration rate (GFR) and onset of end-stage renal disease (ESRD) occur l
Externí odkaz:
https://doaj.org/article/8beb5b69c3a14ce4bc60ffbad23c4ea5
Autor:
Katelyn A. McKenzie, Mirelle El Ters, Vicente E. Torres, Peter C. Harris, Arlene B. Chapman, Michal Mrug, Frederic F. Rahbari-Oskoui, Kyongtae Ty Bae, Douglas P. Landsittel, William M. Bennett, Alan S. L. Yu, Jonathan D. Mahnken
Publikováno v:
BMC Nephrology, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Caffeine has been proposed, based on in vitro cultured cell studies, to accelerate progression of autosomal dominant polycystic kidney disease (ADPKD) by increasing kidney size. Since ADPKD patients are advised to minimize caffein
Externí odkaz:
https://doaj.org/article/9bbfac5e4461453c83ee65a286baa79c
Publikováno v:
Physiological Reports, Vol 7, Iss 16, Pp n/a-n/a (2019)
Abstract This study examined the prospective role of urinary sodium and potassium excretion in depressive symptoms among urban, low‐income adolescents, and whether these relationships vary by gender. A total of 84 urban adolescents (mean age 13.36
Externí odkaz:
https://doaj.org/article/9092573da0224a769486220bc4b13da0
Publikováno v:
SAGE Open Medical Case Reports, Vol 5 (2017)
Objectives: This case report describes two cases of high-dose methotrexate–induced nephrotoxicity: death in the case of conventional supportive care and successful renal function recovery in a patient treated with glucarpidase and continuous dialys
Externí odkaz:
https://doaj.org/article/82951d505c394e35a6103ab6686b060d
Autor:
Michal Mrug, Juling Zhou, Chaozhe Yang, Bruce J Aronow, Xiangqin Cui, Trenton R Schoeb, Gene P Siegal, Bradley K Yoder, Lisa M Guay-Woodford
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135678 (2015)
We have previously mapped the interval on Chromosome 4 for a major polycystic kidney disease modifier (Mpkd) of the B6(Cg)-Cys1cpk/J mouse model of recessive polycystic kidney disease (PKD). Informatic analyses predicted that this interval contains a
Externí odkaz:
https://doaj.org/article/83ff1e1fcce642918d5dc02130b7adf8