Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Michal Mokry"'
Autor:
Suze A. Jansen, Alessandro Cutilli, Coco de Koning, Marliek van Hoesel, Cynthia L. Frederiks, Leire Saiz Sierra, Stefan Nierkens, Michal Mokry, Edward E.S. Nieuwenhuis, Alan M. Hanash, Enric Mocholi, Paul J. Coffer, Caroline A. Lindemans
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110072- (2024)
Summary: The intestine is vulnerable to chemotherapy-induced damage due to the high rate of intestinal epithelial cell (IEC) proliferation. We have developed a human intestinal organoid-based 3D model system to study the direct effect of chemotherapy
Externí odkaz:
https://doaj.org/article/b237740e0ce446bdbb6f4231e7e5bc68
Autor:
Juntao Fang, Qiangbing Yang, Renée G. C. Maas, Michele Buono, Bram Meijlink, Dyonne Lotgerink Bruinenberg, Ernest Diez Benavente, Michal Mokry, Alain van Mil, Li Qian, Marie-José Goumans, Raymond Schiffelers, Zhiyong Lei, Joost P. G. Sluijter
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Background After myocardial infarction, the lost myocardium is replaced by fibrotic tissue, eventually progressively leading to myocardial dysfunction. Direct reprogramming of fibroblasts into cardiomyocytes via the forced overexpression of
Externí odkaz:
https://doaj.org/article/e3965e3745d94f5a8c07effa85a5711d
Autor:
Joost M. Mekke, Tim R. Sakkers, Maarten C. Verwer, Noortje A. M. van den Dungen, Yipei Song, Clint L. Miller, Aloke V. Finn, Gerard Pasterkamp, Michal Mokry, Hester M. den Ruijter, Aryan Vink, Dominique P. V. de Kleijn, Gert J. de Borst, Saskia Haitjema, Sander W. van der Laan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The accumulation of erythrocyte membranes within an atherosclerotic plaque may contribute to the deposition of free cholesterol and thereby the enlargement of the necrotic core. Erythrocyte membranes can be visualized and quantified in the p
Externí odkaz:
https://doaj.org/article/05972807f3624398a1febbfc56363a26
Autor:
Lucas Wilhelmus Picavet, Anoushka A. K. Samat, Jorg Calis, Lotte Nijhuis, Rianne Scholman, Michal Mokry, David F. Tough, Rabinder K. Prinjha, Sebastiaan J. Vastert, Jorg van Loosdregt
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1344 (2024)
T cell activation is critical for an effective immune response against pathogens. However, dysregulation contributes to the pathogenesis of autoimmune diseases, including Juvenile Idiopathic Arthritis (JIA). The molecular mechanisms underlying T cell
Externí odkaz:
https://doaj.org/article/302f5c30f18c430bb29818695732dc2e
Autor:
Talitha C. F. Spanjersberg, Loes A. Oosterhoff, Hedwig S. Kruitwagen, Noortje A. M. van den Dungen, Johannes C. M. Vernooij, Folkert W. Asselbergs, Michal Mokry, Bart Spee, Magdalena Harakalova, Frank G. van Steenbeek
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Vascular pathologies show locational predisposition throughout the body; further insights into the transcriptomics basis of this vascular heterogeneity are needed. We analyzed transcriptomes from cultured endothelial cells and vascular smoot
Externí odkaz:
https://doaj.org/article/084d9af137ee4c1b8e300e79be3a0038
Autor:
Yujiao Zhang, Marie Vandestienne, Jean-Rémi Lavillegrand, Jeremie Joffre, Icia Santos-Zas, Aonghus Lavelle, Xiaodan Zhong, Wilfried Le Goff, Maryse Guérin, Rida Al-Rifai, Ludivine Laurans, Patrick Bruneval, Coralie Guérin, Marc Diedisheim, Melanie Migaud, Anne Puel, Fanny Lanternier, Jean-Laurent Casanova, Clément Cochain, Alma Zernecke, Antoine-Emmanuel Saliba, Michal Mokry, Jean-Sebastien Silvestre, Alain Tedgui, Ziad Mallat, Soraya Taleb, Olivia Lenoir, Cécile Vindis, Stéphane M. Camus, Harry Sokol, Hafid Ait-Oufella
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Caspase recruitment-domain containing protein 9 (CARD9) is a key signaling pathway in macrophages but its role in atherosclerosis is still poorly understood. Global deletion of Card9 in Apoe -/- mice as well as hematopoietic deletion in Ldlr
Externí odkaz:
https://doaj.org/article/b269b498eb06438890385181c12ba8bb
Autor:
Michele F. Buono, Ernest Diez Benavente, Mark Daniels, Barend M. Mol, Joost M. Mekke, Gert J. de Borst, Dominique P. V. de Kleijn, Sander W. van der Laan, Gerard Pasterkamp, Charlotte Onland-Moret, Michal Mokry, Hester M. den Ruijter
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background and aim Sex differences in atherosclerosis have been described with female plaques being mostly perceived as stable and fibrous. Sex-specific mechanisms such as mosaic loss of the Y chromosome in men have been linked to cardiovasc
Externí odkaz:
https://doaj.org/article/4e4428b9f36047999a8fccac55639989
Autor:
Michele F. Buono, Ernest Diez Benavente, Lotte Slenders, Daisey Methorst, Daniëlle Tessels, Eloi Mili, Roxy Finger, Daniek Kapteijn, Mark Daniels, Noortje A. M. van den Dungen, Jorg J. A. Calis, Barend M. Mol, Gert J. de Borst, Dominique P. V. de Kleijn, Gerard Pasterkamp, Hester M. den Ruijter, Michal Mokry
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 21 (2023)
Background Plaque myofibroblasts are critical players in the initiation and advancement of atherosclerotic disease. They are involved in the production of extracellular matrix, the formation of the fibrous cap, and the underlying lipidic core via mod
Externí odkaz:
https://doaj.org/article/cd25f14d033d48ac9391413aa12d5e81
Autor:
Arif Ibrahim Ardisasmita, Imre F. Schene, Indi P. Joore, Gautam Kok, Delilah Hendriks, Benedetta Artegiani, Michal Mokry, Edward E. S. Nieuwenhuis, Sabine A. Fuchs
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
A systematic comparison of transcriptomes across different hepatocyte models provides a valuable resource to determine the most suitable model for a particular application or research question.
Externí odkaz:
https://doaj.org/article/403bc2d40d484beeaa9b734f875b3b5d
Autor:
Enric Mocholi, Laura Russo, Keshav Gopal, Andrew G. Ramstead, Sophia M. Hochrein, Harmjan R. Vos, Geert Geeven, Adeolu O. Adegoke, Anna Hoekstra, Robert M. van Es, Jose Ramos Pittol, Sebastian Vastert, Jared Rutter, Timothy Radstake, Jorg van Loosdregt, Celia Berkers, Michal Mokry, Colin C. Anderson, Ryan M. O’Connell, Martin Vaeth, John Ussher, Boudewijn M.T. Burgering, Paul J. Coffer
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112583- (2023)
Summary: Upon antigen-specific T cell receptor (TCR) engagement, human CD4+ T cells proliferate and differentiate, a process associated with rapid transcriptional changes and metabolic reprogramming. Here, we show that the generation of extramitochon
Externí odkaz:
https://doaj.org/article/942f229d67194e4a9cd020cad65978f5