Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michal Lisnyansky"'
Autor:
Michal Lisnyansky Bar-El, Pavla Vaňková, Adva Yeheskel, Luba Simhaev, Hamutal Engel, Petr Man, Yoni Haitin, Moshe Giladi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The human cis-prenyltransferase (hcis-PT) complex synthesizes the precursor of the glycosyl carrier dolichol-phosphate and as such it is essential for protein N-glycosylation. The crystal structure of the complex reveals unusual tetrameric architectu
Externí odkaz:
https://doaj.org/article/ca8b3c5d53de4fce8b638a000a843aff
Autor:
Michal Lisnyansky Bar-El, Su Youn Lee, Ah Young Ki, Noa Kapelushnik, Anat Loewenstein, Ka Young Chung, Dina Schneidman-Duhovny, Moshe Giladi, Hadas Newman, Yoni Haitin
Publikováno v:
Biomolecules, Vol 9, Iss 11, p 660 (2019)
Dehydrodolichyl diphosphate synthase (DHDDS) is the catalytic subunit of the heteromeric human cis-prenyltransferase complex, synthesizing the glycosyl carrier precursor for N-linked protein glycosylation. Consistent with the important role of N-glyc
Externí odkaz:
https://doaj.org/article/78460d588c3749d3a14e6bd27c96b83c
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 11, p 1949 (2016)
The membrane-bound sodium–calcium exchanger (NCX) proteins shape Ca2+ homeostasis in many cell types, thus participating in a wide range of physiological and pathological processes. Determination of the crystal structure of an archaeal NCX (NCX_Mj)
Externí odkaz:
https://doaj.org/article/552e74c1c447456aa86b1ccf54848516
Autor:
Moshe Giladi, Michal Lisnyansky Bar-El, Pavla Vaňková, Alisa Ferofontov, Emelia Melvin, Suha Alkaderi, Daniel Kavan, Boris Redko, Elvira Haimov, Reuven Wiener, Petr Man, Yoni Haitin
Publikováno v:
Science Advances. 8
Isoprenoids are synthesized by the prenyltransferase superfamily, which is subdivided according to the product stereoisomerism and length. In short- and medium-chain isoprenoids, product length correlates with active site volume. However, enzymes syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75345006112792a709e09e2c3421773b
https://doi.org/10.1126/sciadv.abn1171
https://doi.org/10.1126/sciadv.abn1171
Akademický článek
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The human cis-prenyltransferase (hcis-PT) is an enzymatic complex essential for protein N-glycosylation. Synthesizing the precursor of the glycosyl carrier dolichol-phosphate, we reveal here that hcis-PT exhibits a novel heterotetrameric assembly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ea8dd9b4626bffd25db5ff41e80a7ec
https://doi.org/10.1101/2020.06.02.095570
https://doi.org/10.1101/2020.06.02.095570
Autor:
Anat Loewenstein, Moshe Giladi, Yoni Haitin, Michal Lisnyansky, Ariel Ben-Bassat, Milit Marom, Daniel Khananshvili, Noa Kapelushnik
Publikováno v:
Molecular Pharmacology. 94:1391-1400
Bisphosphonates are widely used for treating osteoporosis, a common disorder in which bone strength is reduced, increasing the risk for fractures. Rarely, bisphosphonates can paradoxically lead to atypical fractures occurring spontaneously or with tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cbc205f3c66457e89be54debdfce4f
https://doi.org/10.1124/mol.118.113670
https://doi.org/10.1124/mol.118.113670
Akademický článek
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Autor:
Michal Lisnyansky, Gilad Twig, Estela Derazne, Alon Peled, Arnon Afek, Itamar Raz, Joseph Mendlovic, Barak Gordon
Publikováno v:
Diabetologia. 60:2226-2230
Immigration studies can shed light on diabetes pathogenesis and risk factors. To this end, we investigated the association between age at immigration and diabetes occurrence at adolescence among immigrants to Israel. We analysed cross-sectional data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e2461a478b70160c938655978330d4
https://doi.org/10.1007/s00125-017-4399-8
https://doi.org/10.1007/s00125-017-4399-8
Autor:
Anat Loewenstein, Yoni Haitin, Michal Lisnyansky, Elon Yariv, Milit Marom, Omri Segal, Nir Ben-Tal, Moshe Giladi
Publikováno v:
Molecular pharmacology. 96(5)
Geranylgeranyl diphosphate synthase (GGPPS) is a central metalloenzyme in the mevalonate pathway, crucial for the prenylation of small GTPases. As small GTPases are pivotal for cellular survival, GGPPS was highlighted as a potential target for treati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d6ffc53b42ea15e33c6b53b38dc734
https://pubmed.ncbi.nlm.nih.gov/31427399
https://pubmed.ncbi.nlm.nih.gov/31427399