Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michal Legiewicz"'
Autor:
David C. Bishop, Lisa Caproni, Kavitha Gowrishankar, Michal Legiewicz, Kinga Karbowniczek, John Tite, David J. Gottlieb, Kenneth P. Micklethwaite
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 359-368 (2020)
CD19-specific chimeric antigen receptor (CAR19) T cells, generated using viral vectors, are an efficacious but costly treatment for B cell malignancies. The nonviral piggyBac transposon system provides a simple and inexpensive alternative for CAR19 T
Externí odkaz:
https://doaj.org/article/83da7d10b4244e449b536afbd1317924
Publikováno v:
Nucleic Acids Research
It has become apparent that much of cellular metabolism is controlled by large well-folded noncoding RNA molecules. In addition to crystallographic approaches, computational methods are needed for visualizing the 3D structure of large RNAs. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c402f26b80368bb5cfa5c1ad7b8a172d
https://doi.org/10.1093/nar/gkt1051
https://doi.org/10.1093/nar/gkt1051
Autor:
David J. Garfinkel, Stuart F.J. Le Grice, Linda D. Eizentstat, Sabrina Lusvarghi, Michal Legiewicz, Katarzyna J. Purzycka, Agniva Saha, Emiko Matsuda
Publikováno v:
Nucleic Acids Research
Ty1, a long terminal repeat retrotransposon of Saccharomyces, is structurally and functionally related to retroviruses. However, a differentiating aspect between these retroelements is the diversity of the replication strategies used by long terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043e39456c1abf3ba30b2a22f89861b4
http://europepmc.org/articles/PMC3592414
http://europepmc.org/articles/PMC3592414
Autor:
Yi Wang, Michaela Wendeler, Stuart F.J. Le Grice, Eckart Bindewald, Bruce A. Shapiro, Mark J. Pritt, Marion K. Bona, Michal Legiewicz
Publikováno v:
RNA. 17:1688-1696
Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) is a facile technique for quantitative analysis of RNA secondary structure. In general, low SHAPE signal values indicate Watson-Crick base-pairing, and high values indicate positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4bad7cdcdbe780a52cf4f059f06931
https://doi.org/10.1261/rna.2640111
https://doi.org/10.1261/rna.2640111
Autor:
Julia C. Kenyon, Sian J. Tanner, Michal Legiewicz, Pretty Susan Phillip, Andrew M. L. Lever, Stuart F. J. Le Grice, Tahir A. Rizvi
Publikováno v:
Nucleic Acids Research
Feline immunodeficiency virus (FIV) infects many species of cat, and is related to HIV, causing a similar pathology. High-throughput selective 2' hydroxyl acylation analysed by primer extension (SHAPE), a technique that allows structural interrogatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26e95405f8c9abd94437e3c294f712a
https://doi.org/10.1093/nar/gkr252
https://doi.org/10.1093/nar/gkr252
Autor:
Andrei S. Zolotukhin, Jenifer Bear, Michelle Mitchell, Guy R. Pilkington, Stuart F. J. Le Grice, George N. Pavlakis, Barbara K. Felber, Katarzyna J. Purzycka, Michal Legiewicz, Hiroaki Uranishi
Publikováno v:
Journal of Biological Chemistry. 285:42097-42104
Retrovirus replication requires specialized transport mechanisms to export genomic mRNA from the nucleus to the cytoplasm of the infected cell. This regulation is mediated by a combination of viral and/or cellular factors that interact with cis-actin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef65983f51913566ab7037dcb12f3070
https://doi.org/10.1074/jbc.m110.182840
https://doi.org/10.1074/jbc.m110.182840
Autor:
Fei Liu, Isabel Chillón, Srinivas Somarowthu, Michal Legiewicz, Marco Marcia, Anna Marie Pyle
The purification and analysis of long noncoding RNAs (lncRNAs) in vitro is a challenge, particularly if one wants to preserve elements of functional structure. Here, we describe a method for purifying lncRNAs that preserves the cotranscriptionally de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3481ee9bed678409a66ed6c4df1d52d6
https://doi.org/10.1016/bs.mie.2015.01.008
https://doi.org/10.1016/bs.mie.2015.01.008
Publikováno v:
RNA. 11:1701-1709
Because the abundance of functional molecules in RNA sequence space has many unexplored aspects, we compared the outcome of 11 independent selections, performed using the same affinity selection protocol and contiguous randomized regions of 16, 22, 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f92fd862a10ee3d691d40e77ddf58c
https://doi.org/10.1261/rna.2161305
https://doi.org/10.1261/rna.2161305
Autor:
Fei Liu, Srinivas Somarowthu, Michal Legiewicz, Anna Marie Pyle, Marco Marcia, Isabel Chillón
Publikováno v:
Molecular cell. 58(2)
Long non-coding RNAs (lncRNAs) have recently emerged as key players in fundamental cellular processes and diseases, but their functions are poorly understood. HOTAIR is a 2,148-nucleotide-long lncRNA molecule involved in physiological epidermal devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54db4b66da9db512b16d9dce52018a0e
https://pubmed.ncbi.nlm.nih.gov/25866246
https://pubmed.ncbi.nlm.nih.gov/25866246
Autor:
Christopher S. Badorrek, Tiffany E. Hamm, Stuart F. J. Le Grice, Kevin B. Turner, Michal Legiewicz, Marie-Louise Hammarskjold, David Rekosh, Daniele Fabris
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(38)
Nuclear export of certain HIV-1 mRNAs requires an interaction between the viral Rev protein and the Rev response element (RRE), a structured element located in the Env region of its RNA genome. This interaction is an attractive target for both drug d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c488b870b95de59a13109379a5a96e7
https://pubmed.ncbi.nlm.nih.gov/18776047
https://pubmed.ncbi.nlm.nih.gov/18776047